| Naslov: | A prognostic human brain network for diffuse midline glioma |
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| Avtorji: | ID Sidpra, Jai (Avtor)
ID Lind, Valentina (Avtor)
ID Cohen, Alexander L. (Avtor)
ID Schaper, Frederic L. W .V. J. (Avtor)
ID Stone, Thomas J (Avtor)
ID Grabovska, Yura (Avtor)
ID Biswas, Asthik (Avtor)
ID Sudhakar, Sniya (Avtor)
ID Sepulveda, Francisco (Avtor)
ID Peres, Bruno S. (Avtor)
ID Avsenik, Jernej (Avtor), et al. |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (77,26 MB)
MD5: 12116CB0BACA9F5F92B634E41A2D683B
 URL - Izvorni URL, za dostop obiščite https://www.nature.com/articles/s41586-026-10631-3
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3-6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3-9 and other glial malignancies10-12 through paracrine mechanisms and direct neuron-to-glioma synapses. However, the organization and clinical implications of these connections in the living human brain remain to be elucidated. Here, we develop tumour network mapping to compute the brain-wide connectivity profile of DMG, defining a conserved brain network across pontine and thalamic DMG associated with patient short-term survival (DMG network). Tumour functional connectivity with the DMG network was independently predictive of patient overall survival across two external validation cohorts. Tumour growth mapped to DMG network-specific trajectories and peak in-network neurometabolic changes across development spatiotemporally aligned with the peak age incidence of DMG. Analyses of single-nucleus RNA sequencing data confirmed diverse synaptic gene enrichment in high-connectivity DMG. Strikingly, incidental surgical resection of high-connectivity thalamic DMG tissue conferred a significant survival advantage. Collectively, these data define a conserved and prognostically important brain network in children with DMG, consistent with the hypothesis that DMGs exploit otherwise healthy brain circuits to promote tumour growth. |
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| Ključne besede: | diffuse midline glioma, brain networks, prognosis, brain mapping |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2026 |
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| Št. strani: | str. 769-779 |
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| Številčenje: | Vol. 655, issue 8123 |
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| PID: | 20.500.12556/DiRROS-31315  |
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| UDK: | 616.8-006 |
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| ISSN pri članku: | 1476-4687 |
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| DOI: | 10.1038/s41586-026-10631-3 |
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| COBISS.SI-ID: | 281328131 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 19. 1. 2026;
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| Datum objave v DiRROS: | 27.07.2026 |
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| Število ogledov: | 117 |
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| Število prenosov: | 70 |
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| Metapodatki: |    |
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