| Naslov: | Management of Tacrolimus-induced thrombotic microangiopathy in a heart transplant recipient : utilizing novel immunosuppression strategies |
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| Avtorji: | ID Girandon Sušanj, Petra (Avtor)
ID Okrajšek, Renata (Avtor)
ID Frljak, Sabina (Avtor)
ID Zemljič, Gregor (Avtor)
ID Cerar, Andraž (Avtor)
ID Šebeštjen, Miran (Avtor)
ID Ugovšek, Sabina (Avtor)
ID Bajec, Tine (Avtor)
ID Poglajen, Gregor (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (1,51 MB)
MD5: A34D5721CABD9F99065A55546F11FBE4
 URL - Izvorni URL, za dostop obiščite https://www.jhltopen.org/article/S2950-1334(26)00117-5/fulltext
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.03 - Drugi znanstveni članki |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Thrombotic microangiopathy (TMA) represents a heterogeneous group of disorders characterized by endothelial injury, complement activation, and platelet aggregation, and may occur in association with systemic diseases, infections, or drug exposure. In solid organ transplant recipients, TMA is most commonly linked to immunosuppressive therapy, particularly calcineurin inhibitors and mammalian target of rapamycin inhibitors, with increased risk during combined use. Drug-induced TMA is rare but potentially life-threatening, and management relies primarily on prompt withdrawal of the offending agent and modification of immunosuppression. We report the successful use of belatacept-based immunosuppression in a heart transplant recipient with tacrolimus-associated TMA. Belatacept, a selective T-cell costimulation blocker, represents a promising alternative immunosuppressive strategy in this setting, particularly in patients with drug-related vascular toxicity. |
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| Ključne besede: | thrombotic microangiopathy, calcineurin inhibitors, mechanistic target of rapamycin, belatacept |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2026 |
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| Št. strani: | 4 str. |
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| Številčenje: | Vol. 13, article no. ǂ100596 |
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| PID: | 20.500.12556/DiRROS-30693  |
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| UDK: | 616.1 |
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| ISSN pri članku: | 2950-1334 |
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| DOI: | 10.1016/j.jhlto.2026.100596 |
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| COBISS.SI-ID: | 281921539 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 17. 6. 2026;
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| Datum objave v DiRROS: | 01.07.2026 |
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| Število ogledov: | 73 |
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| Število prenosov: | 59 |
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| Metapodatki: |    |
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