| Naslov: | Herpesviridae and atypical bacteria co-detections in lower respiratory tract samples of SARS-CoV-2-positive patients admitted to an intensive care unit |
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| Avtorji: | ID Grubelnik, Gašper (Avtor)
ID Korva, Miša (Avtor)
ID Kogoj, Rok (Avtor)
ID Polanc, Tina (Avtor)
ID Mavrič, Matej (Avtor)
ID Jevšnik Virant, Monika (Avtor)
ID Uršič, Tina (Avtor)
ID Keše, Darja (Avtor)
ID Seme, Katja (Avtor)
ID Petrovec, Miroslav (Avtor)
ID Jereb, Matjaž (Avtor)
ID Avšič-Županc, Tatjana (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (1,03 MB)
MD5: 9096CBA69D1DE657985DC08185C770B3
 URL - Izvorni URL, za dostop obiščite https://www.mdpi.com/2076-2607/12/4/714
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Shortly after the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), cases of viral, bacterial, and fungal coinfections in hospitalized patients became evident. This retrospective study investigates the prevalence of multiple pathogen co-detections in 1472 lower respiratory tract (LRT) samples from 229 SARS-CoV-2-positive patients treated in the largest intensive care unit (ICU) in Slovenia. In addition to SARS-CoV-2, (rt)RT-PCR tests were used to detect cytomegalovirus (CMV), Epstein–Barr virus (EBV), herpes simplex virus 1 (HSV-1), herpes simplex virus 2 (HSV-2), varicella zoster virus (VZV), and atypical bacteria: Chlamydia pneumoniae, Mycoplasma pneumoniae and Legionella pneumophila/spp. At least one co-detection was observed in 89.1% of patients. EBV, HSV-1, and CMV were the most common, with 74.7%, 58.1%, and 38.0% of positive patients, respectively. The median detection time of EBV, HSV-1, and CMV after initial SARS-CoV-2 confirmation was 11 to 20 days. Bronchoalveolar lavage (BAL) and tracheal aspirate (TA) samples showed equivalent performance for the detection of EBV, CMV, and HSV-1 in patients with both available samples. Our results indicate that SARS-CoV-2 infection could be a risk factor for latent herpesvirus reactivation, especially HSV-1, EBV, and CMV. However, additional studies are needed to elucidate the clinical importance of these findings. |
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| Ključne besede: | SARS-CoV-2, co-detections, coinfections, lower respiratory tract, ICU, herpesviruses, atypical bacteria |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2024 |
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| Št. strani: | str. 1-14 |
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| Številčenje: | Vol. 12, iss. 4, [article no.] 714 |
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| PID: | 20.500.12556/DiRROS-30063  |
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| UDK: | 578 |
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| ISSN pri članku: | 2076-2607 |
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| DOI: | 10.3390/microorganisms12040714 |
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| COBISS.SI-ID: | 192370691 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 12. 4. 2024;
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| Datum objave v DiRROS: | 12.06.2026 |
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| Število ogledov: | 40 |
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| Število prenosov: | 17 |
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| Metapodatki: |    |
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