| Naslov: | Unraveling the role of IL-17 in lichen planus : a comparative investigation of clinical variability and immunopathogenic pathways |
|---|
| Avtorji: | ID Tolušić Levak, Maja (Avtor)
ID Pauzar, Mirta (Avtor)
ID Plužarić, Vera (Avtor)
ID Francesch, Nika (Avtor)
ID Pauzar, Biljana (Avtor)
ID Rajc, Jasmina (Avtor)
ID Delaš Aždajić, Marija (Avtor)
ID Mihalj, Martina (Avtor) |
|---|
| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2025.14/actaapa.2025.14.pdf
 PDF - Predstavitvena datoteka, prenos (24,39 MB)
MD5: 46ADC2DE312AC96841B9B9E70937F422
|
|---|
| Jezik: | Angleški jezik |
|---|
| Tipologija: | 1.01 - Izvirni znanstveni članek |
|---|
| Organizacija: |  ZSD - Združenje slovenskih dermatovenerologov
|
|---|
| Povzetek: | Introduction: Lichen planus (LP) is a chronic T cell–mediated inflammatory disease affecting the skin and mucosa. Interleukin-17 (IL-17), a pro-inflammatory cytokine, has been implicated in LP pathogenesis, but its tissue-level expression across clinical variants remains underexplored. This study compares IL-17 expression in healthy skin and LP lesions and assesses variations based on clinical presentation. Methods: This cross-sectional retrospective study included 20 LP skin samples and 10 healthy controls. The sample collection spanned a period of 10 years. IL-17 expression was assessed via immunohistochemistry and quantified using a modified Q score. Samples were categorized by mucosal involvement and lesion distribution. Statistical analysis was performed with the MannWhitney U test. Results: IL-17 was absent in healthy skin but present in all LP samples. IL-17 expression was significantly higher in patients with both skin and oral mucosal involvement compared to those with cutaneous LP (p = 0.003). No significant difference was observed between generalized and localized LP. Conclusions: The results indicate a distinct increase in IL-17 expression in LP lesions, particularly with mucosal involvement, supporting its role in LP pathogenesis. These findings suggest IL-17 as a potential biomarker and therapeutic target, warranting further investigation in larger cohorts. |
|---|
| Ključne besede: | inflammatory dermatoses, lichen planus, interleukin-17, immunoexpression |
|---|
| Status publikacije: | Objavljeno |
|---|
| Verzija publikacije: | Objavljena publikacija |
|---|
| Datum objave: | 01.06.2025 |
|---|
| Leto izida: | 2025 |
|---|
| Št. strani: | str. 51-54 |
|---|
| Številčenje: | Vol. 34, issue 2 |
|---|
| PID: | 20.500.12556/DiRROS-29904  |
|---|
| UDK: | 616.5:579 |
|---|
| ISSN pri članku: | 1318-4458 |
|---|
| DOI: | 10.15570/actaapa.2025.14 |
|---|
| COBISS.SI-ID: | 260270851 |
|---|
| Datum objave v DiRROS: | 15.06.2026 |
|---|
| Število ogledov: | 50 |
|---|
| Število prenosov: | 22 |
|---|
| Metapodatki: |    |
|---|
|
:
|
Kopiraj citat |
|---|
| | | | Objavi na: |  |
|---|
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše
podrobnosti ali sproži prenos. |
