| Naslov: | In Parkinson’s disease dopaminergic medication and deep brain stimulation of the subthalamic nucleus increase motor, but not reflection and cognitive impulsivity |
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| Avtorji: | ID Hendriks, Martijn (Avtor)
ID Vinke, Ruben Saman (Avtor)
ID Berlot, Rok (Avtor)
ID Benedičič, Mitja (Avtor)
ID Jahansahi, Marjan (Avtor)
ID Trošt, Maja (Avtor)
ID Georgiev, Dejan (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (1,36 MB)
MD5: E56944E2D300D822EFD305636759CA59
 URL - Izvorni URL, za dostop obiščite https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1378614/full
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Background: Parkinson’s disease is associated with increased impulsivity, which can be divided into several domains: motor (consisting of proactive and reactive subdomains), reflection, and cognitive impulsivity. Evidence suggests that both dopaminergic medication and subthalamic nucleus deep brain stimulation can affect impulsivity. Therefore, we set out to investigate the effects of dopaminergic medication and subthalamic nucleus deep brain stimulation on motor, reflection, and cognitive impulsivity in Parkinson’s disease patients. Methods: Twenty Parkinson’s disease patients who underwent subthalamic nucleus deep brain stimulation were tested ON and OFF dopaminergic medication and ON and OFF subthalamic nucleus deep brain stimulation. They performed three different impulsivity tasks: the AX continuous performance task (AX-CPT) to test for motor impulsivity, the Beads task for reflection impulsivity, and the Delay discounting task for cognitive impulsivity. Results: The combination of subthalamic nucleus deep brain stimulation and dopaminergic medication led to an increase in motor impulsivity (p = 0.036), both proactive (p = 0.045) and reactive (p = 0.006). There was no effect of either dopaminergic medication or subthalamic nucleus deep brain stimulation on reflection and cognitive impulsivity. Conclusion: The combination of dopaminergic medication and subthalamic nucleus deep brain stimulation leads to increased motor, but not cognitive or reflection, impulsivity in patients with Parkinson’s disease. Both proactive and reactive motor impulsivity were impaired by the combination of dopaminergic medication and subthalamic nucleus deep brain stimulation |
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| Ključne besede: | deep brain stimulation, dopaminergic medication, motor impulsivity, cognitive impulsivity, reflection impulsivity, Parkinson’s disease |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2024 |
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| Št. strani: | 9 str. |
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| Številčenje: | Vol. 18 |
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| PID: | 20.500.12556/DiRROS-29850  |
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| UDK: | 616.8 |
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| ISSN pri članku: | 1662-453X |
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| DOI: | 10.3389/fnins.2024.1378614 |
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| COBISS.SI-ID: | 199948547 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 26. 6. 2024;
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| Datum objave v DiRROS: | 08.06.2026 |
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| Število ogledov: | 92 |
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| Število prenosov: | 52 |
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| Metapodatki: |    |
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