| Naslov: | Maternal APOE [epsilon]2 as a possible risk factor for elevated prenatal Pb levels |
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| Avtorji: | ID Palir, Neža (Avtor)
ID Stajnko, Anja (Avtor)
ID Mazej, Darja (Avtor)
ID France Štiglic, Alenka (Avtor)
ID Snoj Tratnik, Janja (Avtor)
ID Runkel, Agneta Annika (Avtor)
ID Marc, Janja (Avtor)
ID Horvat, Milena (Avtor)
ID Falnoga, Ingrid (Avtor), et al. |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (4,62 MB)
MD5: A2D26D2BF4A0BB79D1A8507027AB6D01
 URL - Izvorni URL, za dostop obiščite https://www.sciencedirect.com/science/article/pii/S0013935124014889
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Lead (Pb) is a global contaminant associated with multiple adverse health effects. Humans are especially vulnerable during critical developmental stages. During pregnancy, exposure to Pb can occur through diet and release from maternal bones. Apolipoprotein E gene (APOE) variants (ɛ2, ɛ3, ɛ4 alleles) may influence sex steroid hormones, bone metabolism, and Pb kinetics. We examined the interplay among maternal APOE (mAPOE) genotypes, fetal sex, parity, and Pb in maternal and cord blood (mB-Pb, CB-Pb) using linear regression models. Our study involved 817 pregnant women and 772 newborns with measured adequate levels of zinc and selenium. We compared carriers of the ε2 and ε4 alleles to those with the ε3/ε3 genotype. The geometric means (range) of mB-Pb and CB-Pb were 11.1 (3.58–87.6) and 9.31 (1.82–47.0) ng/g, respectively. In cases with female fetuses, the maternal mAPOE ε2 allele was associated with higher, while the mAPOE ε4 allele was associated with lower mB-Pb and CB-Pb levels. Nulliparity increased the strength of the observed associations. These findings highlight the significance of mAPOE genetics, fetal sex, and parity in prenatal Pb kinetics. Notably, the maternal ε2 allele may increase the risk of Pb exposure. |
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| Ključne besede: | cord blood, maternal APOE ε2 allele, bone turnover, fetal sex, parity |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2024 |
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| Št. strani: | str. 1-12 |
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| Številčenje: | Vol. 260, [article no.] 119583 |
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| PID: | 20.500.12556/DiRROS-29805  |
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| UDK: | 504.5 |
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| ISSN pri članku: | 1096-0953 |
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| DOI: | 10.1016/j.envres.2024.119583 |
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| COBISS.SI-ID: | 202005507 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 17. 7. 2024;
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| Datum objave v DiRROS: | 05.06.2026 |
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| Število ogledov: | 26 |
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| Število prenosov: | 13 |
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| Metapodatki: |    |
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