| Naslov: | Clinical efficacy and pharmacokinetics of antivenom Viperfav® in Vipera ammodytes ammodytes envenomation |
|---|
| Avtorji: | ID Kurtović, Tihana (Avtor)
ID Dobaja, Mojca (Avtor)
ID Grenc, Damjan (Avtor)
ID Leonardi, Adrijana (Avtor)
ID Križaj, Igor (Avtor)
ID Lukšić, Boris (Avtor)
ID Halassy, Beata (Avtor)
ID Brvar, Miran (Avtor) |
|---|
| Datoteke: |  PDF - Predstavitvena datoteka, prenos (239,45 KB)
MD5: 32BB9324D6D8C9F9536B3327846B455B
 URL - Izvorni URL, za dostop obiščite https://www.mdpi.com/1999-4923/17/11/1431
|
|---|
| Jezik: | Angleški jezik |
|---|
| Tipologija: | 1.01 - Izvirni znanstveni članek |
|---|
| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
|
|---|
| Povzetek: | Background: In Europe, Vipera ammodytes ammodytes (Vaa, nose-horned viper) is considered the most venomous of the European vipers. The antivenom Viperfav®, composed of polyvalent equine F(ab′)2 fragments, is effective against Vipera aspis, Vipera berus and Vaa. Objectives: This study aimed to evaluate the clinical efficacy and pharmacokinetics of Viperfav in Vaa envenomations. Methods: Patients presenting with Vaa snakebite and treated with intravenous Viperfav were included. Clinical manifestations and laboratory findings were assessed on admission to the Emergency Department, prior to antivenom therapy, and monitored throughout hospitalization. Blood samples were collected on arrival and at defined intervals after Viperfav administration. Venom and antivenom concentrations in serum were determined by ELISA and subjected to pharmacokinetic analysis. Results: Twenty-one patients bitten by Vaa and classified with a severity score of 2b on the modified Audebert clinical severity scale received a single intravenous dose of Viperfav within 4 h of the bite. Viperfav attenuated the progression of local symptoms and prevented the development of new systemic manifestations. The serum concentrations of F(ab′)2 fragments reached 196 µg/mL, far exceeding the venom concentration at admission (35 ng/mL). The prolonged elimination half-life of Viperfav (49 h) corresponded with the absence of recurrent symptoms after a single dose. Bradycardia or hypotension occurred in 10% of patients; no cases of anaphylaxis or serum sickness were observed. Conclusions: A single intravenous dose of Viperfav demonstrated clinical efficacy and a favourable pharmacokinetic profile in Vaa envenomed patients when administered within hours of the bite. |
|---|
| Ključne besede: | snake venom, antivenom, Viperfav |
|---|
| Status publikacije: | Objavljeno |
|---|
| Verzija publikacije: | Objavljena publikacija |
|---|
| Leto izida: | 2025 |
|---|
| Št. strani: | str. 1-12 |
|---|
| Številčenje: | Vol. 17, iss. 11, [article no.] 1431 |
|---|
| PID: | 20.500.12556/DiRROS-29037  |
|---|
| UDK: | 577 |
|---|
| ISSN pri članku: | 1999-4923 |
|---|
| DOI: | 10.3390/pharmaceutics17111431 |
|---|
| COBISS.SI-ID: | 256886275 |
|---|
| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 12. 11. 2025;
|
|---|
| Datum objave v DiRROS: | 17.04.2026 |
|---|
| Število ogledov: | 34 |
|---|
| Število prenosov: | 16 |
|---|
| Metapodatki: |    |
|---|
|
:
|
Kopiraj citat |
|---|
| | | | Objavi na: |  |
|---|
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše
podrobnosti ali sproži prenos. |
