| Naslov: | Population and single-cell analyses reveal immune cell-specific expression profiles associated with Alzheimer's disease risk |
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| Avtorji: | ID Lindbohm, Joni V. (Avtor)
ID Stražar, Martin (Avtor)
ID Lee, Hang-Mao (Avtor)
ID Ashenberg, Orr (Avtor)
ID Mars, Nina (Avtor) |
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| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://doi.org/10.1002/alz.71282
 PDF - Predstavitvena datoteka, prenos (4,11 MB)
MD5: CC684CA3D3A0759E6434488449FCA336
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  NIB - Nacionalni inštitut za biologijo
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| Povzetek: | INTRODUCTION Dysregulation of the peripheral immune system may increase Alzheimer's disease (AD) risk, but the underlying cell type-specific mechanisms remain unclear. METHODS We conducted Mendelian randomization and colocalization analyses of 4489 genes using single-cell expression quantitative trait locus data from unstimulated and stimulated peripheral immune cells, integrated with an AD genome-wide association study (N = 455,258). Spatial transcriptomics of brain tissue samples was used to identify brain-infiltrating immune cells. RESULTS Thirteen genes were associated with AD risk. Expression of BIN1, CTSW, CTSH, HLA-DRB1, TSTD1, PLEKHA1, and SCIMP increased AD risk, while EPHA1-AS1, FCER1G, FIBP, KAT8, STX4, and HLA-DQA1 reduced it. These associations were peripheral immune cell type and state specific. PLEKHA1 and TSTD1 were upregulated and FIBP downregulated in natural killer and T cells in AD brain tissue. DISCUSSION These findings link immune cell-specific gene expression to AD risk across activation states and within brain-infiltrating immune cells, highlighting potential targets for immune-based AD prevention and treatment. |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 22.03.2026 |
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| Leto izida: | 2026 |
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| Št. strani: | str. 1-14 |
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| Številčenje: | Vol. 22, iss. 3, [article no.] e71282 |
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| PID: | 20.500.12556/DiRROS-28598  |
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| UDK: | 616.8 |
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| ISSN pri članku: | 1552-5279 |
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| DOI: | 10.1002/alz.71282 |
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| COBISS.SI-ID: | 272963843 |
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| Opomba: | Slovenski soavtorji: Martin Stražar, Hang-Mao Lee, Orr Ashenberg, Nina Mars, Pyry N. Sipilä, Samuli Ripatti, Dan Graham, Mika Kivimäki, Ramnik J. Xavier;
Nasl. z nasl. zaslona;
Opis vira z dne 25. 3. 2026;
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| Datum objave v DiRROS: | 25.03.2026 |
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| Število ogledov: | 187 |
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| Število prenosov: | 119 |
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| Metapodatki: |    |
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