| Naslov: | Interchangeability of patient pain, fatigue and global scores in patients with spondyloarthritis : a registry-based simulation study |
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| Avtorji: | ID Georgiadis, Stylianos (Avtor)
ID Di Giuseppe, Daniela (Avtor)
ID Scherer, Almut (Avtor)
ID Lund Hetland, Merete (Avtor)
ID Jones, Gareth T. (Avtor)
ID Glintborg, Bente (Avtor)
ID Gitte Loft, Anne (Avtor)
ID Wallman, Johan Karlsson (Avtor)
ID Michelsen, Brigitte (Avtor)
ID Kristianslund, Eirik Klami (Avtor)
ID Rotar, Žiga (Avtor)
ID Tomšič, Matija (Avtor), et al. |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (2,19 MB)
MD5: 92367B765FD150A98B1AE5CC7B87E203
 URL - Izvorni URL, za dostop obiščite https://bmcrheumatol.biomedcentral.com/articles/10.1186/s41927-025-00527-6
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Background: To investigate a patient-level single imputation approach for patient reported outcomes (PROs) that express similar contents or associated PROs, where a PRO whose value is missing at a particular timepoint is substituted by another PRO whose value is available at the same timepoint. Methods: We performed a simulation study on registry-based spondyloarthritis data to explore the potential interchangeability between the patient pain (PPA) and fatigue (PFA) assessment scores and relevant Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) individual questions, and between PPA, PFA and patient global assessment (PGA). Performance was assessed per imputation method in terms of relative bias and coverage. Sample size, level of missingness and missing data pattern were included as parameters in the simulations. Results: All applied scenarios to interchange PPA with BASDAI question 2 (axial pain), BASDAI question 3 (peripheral joint pain/swelling) or their average failed. Interchangeability between PFA and BASDAI question 1 (fatigue/tiredness) was acceptable for partially (up to 50%) missing data. When interchanging patient assessment scores (PPA, PFA and PGA), we observed inconsistent results in terms of performance. The performance of the applied methods depended on the sample size and the level of missingness, but not heavily on the underlying missing data pattern. Conclusions: Interchanging PFA and the BASDAI fatigue question was justified for partially missing data, while interchangeability between PPA, PFA and PGA, and between PPA and the BASDAI pain questions was not advised. Our findings suggest that registering patient assessment scores and BASDAI questions is recommended. |
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| Ključne besede: | missing data, patient reported outcomes, registry data, single imputation, spondyloarthritis |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2025 |
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| Št. strani: | str. 1-11 |
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| Številčenje: | Vol. 9, iss. 1, [Article no.] 75 |
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| PID: | 20.500.12556/DiRROS-28131  |
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| UDK: | 616-097 |
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| ISSN pri članku: | 2520-1026 |
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| DOI: | 10.1186/s41927-025-00527-6 |
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| COBISS.SI-ID: | 243894275 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne: 25. 7. 2025;
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| Datum objave v DiRROS: | 10.03.2026 |
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| Število ogledov: | 25 |
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| Število prenosov: | 8 |
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| Metapodatki: |    |
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