| Naslov: | Stroke frequency, associated factors, and clinical features in primary systemic vasculitis : a multicentric observational study |
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| Avtorji: | ID Geraldes, Ruth (Avtor)
ID Santos, Mónica S. F. (Avtor)
ID Ponte, Cristina (Avtor)
ID Craven, Anthea (Avtor)
ID Barra, Lillian (Avtor)
ID Robson, Joanna C. (Avtor)
ID Hammam, Nevin (Avtor)
ID Springer, Jason (Avtor)
ID Henes, Jöerg (Avtor)
ID Hočevar, Alojzija (Avtor), et al. |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (1,37 MB)
MD5: ABDBE5B03C1886E248E113726DEE6211
 URL - Izvorni URL, za dostop obiščite https://link.springer.com/article/10.1007/s00415-024-12251-1
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Objectives: The cerebral vessels may be affected in primary systemic vasculitis (PSV), but little is known about cerebrovascular events (CVEs) in this population. This study aimed to determine the frequency of CVEs at the time of diagnosis of PSV, to identify factors associated with CVEs in PSV, and to explore features and outcomes of stroke in patients with PSV. Methods: Data from adults newly diagnosed with PSV within the Diagnostic and Classification Criteria in VASculitis (DCVAS) study were analysed. Demographics, risk factors for vascular disease, and clinical features were compared between patients with PSV with and without CVE. Stroke subtypes and cumulative incidence of recurrent CVE during a prospective 6-month follow-up were also assessed. Results: The analysis included 4828 PSV patients, and a CVE was reported in 169 (3.50%, 95% CI 3.00-4.06): 102 (2.13% 95% CI 1.73-2.56) with stroke and 81 (1.68% 95% CI 1.33-2.08) with transient ischemic attack (TIA). The frequency of CVE was highest in Behçet's disease (9.5%, 95% CI 5.79-14.37), polyarteritis nodosa (6.2%, 95% CI 3.25-10.61), and Takayasu's arteritis (6.0%, 95% CI 4.30-8.19), and lowest in microscopic polyangiitis (2.2%, 95% CI 1.09-3.86), granulomatosis with polyangiitis (2.0%, 95% CI 1.20-3.01), cryoglobulinaemic vasculitis (1.9%, 95% CI 0.05-9.89), and IgA-vasculitis (Henoch-Schönlein) (0.4%, 95% CI 0.01-2.05). PSV patients had a 11.9% cumulative incidence of recurrent CVE during a 6-month follow-up period. Conclusion: CVEs affect a significant proportion of patients at time of PSV diagnosis, and the frequency varies widely among different vasculitis, being higher in Behçet's. Overall, CVE in PSV is not explained by traditional vascular risk factors and has a high risk of CVE recurrence. |
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| Ključne besede: | cerebrovascular event, primary systemic vasculitis, stroke, transient ischaemic attack |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2024 |
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| Št. strani: | str. 3309-3320 |
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| Številčenje: | Vol. 271, iss. 6 |
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| PID: | 20.500.12556/DiRROS-27830  |
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| UDK: | 616.8 |
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| ISSN pri članku: | 1432-1459 |
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| DOI: | 10.1007/s00415-024-12251-1 |
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| COBISS.SI-ID: | 225876995 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 7. 2. 2025;
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| Datum objave v DiRROS: | 26.02.2026 |
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| Število ogledov: | 188 |
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| Število prenosov: | 110 |
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| Metapodatki: |    |
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