| Naslov: | Long-term outcomes of reduced-dose bleomycin in electrochemotherapy for basal cell carcinoma in elderly patients |
|---|
| Avtorji: | ID Grošelj, Aleš (Avtor)
ID Jamšek, Črt (Avtor)
ID Kranjc Brezar, Simona (Avtor)
ID Čemažar, Maja (Avtor)
ID Omerzel, Maša (Avtor)
ID Pušnik, Luka (Avtor)
ID Serša, Gregor (Avtor) |
|---|
| Datoteke: |  PDF - Predstavitvena datoteka, prenos (1,23 MB)
MD5: CEAA737C686B061EF4C459C8DB423C80
 URL - Izvorni URL, za dostop obiščite https://www.nature.com/articles/s41598-025-93104-3
|
|---|
| Jezik: | Angleški jezik |
|---|
| Tipologija: | 1.01 - Izvirni znanstveni članek |
|---|
| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
|
|---|
| Povzetek: | Electrochemotherapy (ECT) is a minimally invasive treatment option for basal cell carcinoma (BCC), which is particularly advantageous in the elderly population. This study evaluated the long-term effects of treating BCC in older patients using ECT with a reduced dose of bleomycin (10,000 IU/m2) and compared the results to patients who received the standard dose of bleomycin (15,000 IU/m2). The retrospective analysis included 116 patients aged over 65 years with 257 histologically confirmed BCCs. Tumors were treated with either the standard dose (n = 82) or the reduced dose (n = 175) of bleomycin. The results showed that the recurrence rate was comparable between the groups, particularly in the first year after treatment. The reduced-dose group exhibited a greater recurrence rate after the first year, which may be attributed to a weaker local immune response due to the de-escalated dose of bleomycin. Nonetheless, administering a standard bleomycin dosage as a salvage treatment in the event of recurrence proved highly effective. These findings suggest that ECT with a reduced bleomycin dose is a viable option for treating BCC in elderly patients, particularly those with shorter life expectancy. |
|---|
| Ključne besede: | bleomycin, electrochemotherapy, head and neck, nonmelanoma skin cancer |
|---|
| Status publikacije: | Objavljeno |
|---|
| Verzija publikacije: | Objavljena publikacija |
|---|
| Leto izida: | 2025 |
|---|
| Št. strani: | str. 1-7 |
|---|
| Številčenje: | Vol. 15, no. 1 |
|---|
| PID: | 20.500.12556/DiRROS-24311  |
|---|
| UDK: | 616-006 |
|---|
| ISSN pri članku: | 2045-2322 |
|---|
| DOI: | 10.1038/s41598-025-93104-3 |
|---|
| COBISS.SI-ID: | 234048259 |
|---|
| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 23. 4. 2025;
|
|---|
| Datum objave v DiRROS: | 25.11.2025 |
|---|
| Število ogledov: | 135 |
|---|
| Število prenosov: | 106 |
|---|
| Metapodatki: |    |
|---|
|
:
|
Kopiraj citat |
|---|
| | | | Objavi na: |  |
|---|
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše
podrobnosti ali sproži prenos. |
