| Naslov: | Gut microbiome in cancer : the next big opportunity for better patient outcomes? |
|---|
| Avtorji: | ID Povšin, Jure (Avtor)
ID Sotošek, Timotej (Avtor)
ID Novak, Metka (Avtor)
ID Breznik, Barbara (Avtor) |
|---|
| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://www.slovetres.si/index.php/SVR/article/view/2029
 PDF - Predstavitvena datoteka, prenos (785,91 KB)
MD5: 8E5B20EAD174BB5B9B37643B2593766A
|
|---|
| Jezik: | Angleški jezik |
|---|
| Tipologija: | 1.02 - Pregledni znanstveni članek |
|---|
| Organizacija: |  NIB - Nacionalni inštitut za biologijo
|
|---|
| Povzetek: | The gut microbiome, a diverse community of microorganisms in the human body, plays an important role in maintaining health and influences various processes such as digestion, immunity, and protection against pathogens. A person's unique gut microbiome, shaped by factors such as birth method, diet, antibiotics, and lifestyle, contributes to bodily functions such as nutrient metabolism, drug processing, and im-mune regulation. Changes in the gut microbiome are associated with a predisposition to cancer and can influence the effectiveness of cancer treatments. Dysbiosis in the gut microbiome can lead to inflammation, tumor development, and metastasis, highlight-ing its importance in cancer research and prevention. The gut microbiota significantly influences cancer development and treatment outcomes. Certain bacteria enhance the effects of therapies such as cyclophosphamide and contribute to the body's im-mune response against tumors. Microbes produce anti-cancer molecules and probiotic compounds, making them potential tools in cancer prevention and treatment. Future research aims to develop targeted antibiotics and explore fecal microbiota transfer to selectively manipulate the microbiota for improved cancer treatment. Due to genetic and physiological similarities, mouse models are invaluable in biomedical research. However, because the gut microbiome of humans and mice and the composition of the tumor microenvironment differ, direct comparison between these two models can be challenging in research. Bridging these gaps is crucial for comparative medicine, especially in cancer research where the microbiome plays an important role in treat-ment outcomes. One important area where the gut microbiome could offer potential new treatment options is in primary brain tumors such as gliomas. To date, there are no long-lasting effective treatments for this type of cancer, but research in mouse models shows a link between tumor progression and response to treatment with changes in the gut microbiome. Overall, the gut microbiome and its modulation represent an opportu-nity for more efficient future cancer treatment. |
|---|
| Ključne besede: | gut microbiome, cancer, treatment outcome, tumor models, glioma |
|---|
| Status publikacije: | Objavljeno |
|---|
| Verzija publikacije: | Objavljena publikacija |
|---|
| Datum objave: | 28.02.2025 |
|---|
| Leto izida: | 2025 |
|---|
| Št. strani: | str. 13-26 |
|---|
| Številčenje: | Vol. 62, suppl. 27 |
|---|
| PID: | 20.500.12556/DiRROS-21821  |
|---|
| UDK: | 543.95:576.36:591.434:616-006:616-052:636.09 |
|---|
| ISSN pri članku: | 1580-4003 |
|---|
| DOI: | 10.26873/SVR-2029-2024 |
|---|
| COBISS.SI-ID: | 229131267 |
|---|
| Opomba: | Soavtorji: Timotej Sotošek, Metka Novak, Barbara Breznik;
|
|---|
| Datum objave v DiRROS: | 03.04.2025 |
|---|
| Število ogledov: | 144 |
|---|
| Število prenosov: | 69 |
|---|
| Metapodatki: |    |
|---|
|
:
|
POVŠIN, Jure, SOTOŠEK, Timotej, NOVAK, Metka in BREZNIK, Barbara, 2025, Gut microbiome in cancer : the next big opportunity for better patient outcomes? Slovenian veterinary research : the scientific journal of the Veterinary Faculty University of Ljubljana [na spletu]. 2025. Vol. 62, no. suppl. 27, p. 13–26. [Dostopano 6 april 2025]. DOI 10.26873/SVR-2029-2024. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=21821
|
|---|
| | | | Objavi na: |  |
|---|
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše
podrobnosti ali sproži prenos. |
