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Naslov:Development of the fish invitrome for animal-free environmental risk assessment of chemicals
Avtorji:ID Revel, Marion (Avtor)
ID Groh, Ksenia J (Avtor)
ID Bertoli, Jessica (Avtor)
ID Degeratu, Mihai-Ovidiu (Avtor)
ID Fischer, Melanie (Avtor)
ID Fischer, Stephan (Avtor)
ID Hoekman, Jarno (Avtor)
ID Jozef, Barbara (Avtor)
ID Li, Roman (Avtor)
ID Županič, Anže (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://doi.org/10.1093/etojnl/vgaf028
 
.pdf PDF - Predstavitvena datoteka, prenos (1,24 MB)
MD5: F363F850CB8F131971FAF3EE77597C36
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo NIB - Nacionalni inštitut za biologijo
Povzetek:Given the need to reduce animal testing for environmental risk assessment, we aim to develop a fish invitrome, an alternative fish modular framework capable of predicting chemical toxicity in fish without the use of animals. The central module of the framework is the validated RTgill-W1 cell line assay that predicts fish acute toxicity of chemicals (Organization for Economic Cooperation and Development Test Guideline (OECD TG) 249). Expanding towards prediction of chronic toxicity, the fish invitrome includes two other well-advanced modules for chemical bioaccumulation/biotransformation and inhibition of fish growth. This framework is expected to continuously evolve with the development of modules that predict, for instance, neurotoxicity and reproductive toxicity. We envisage the fish invitrome framework to become part of the broader academic field of New Approach Methodologies (NAMs), where it will remain flexible and open to integration of new developments from research groups around the world. To accelerate the development and uptake of this framework, we strive for transdisciplinarity, integrating both natural and social sciences, along with broader stakeholder interactions. A stepwise socio-technical approach has been chosen, where mainstreaming the fish invitrome involves progressive adoption across various ecotoxicological contexts. The framework will be co-designed with stakeholders from academia, industry, and regulatory bodies. Rather than aiming for immediate regulatory acceptance, this approach aims to build trust and familiarity with fish cell line-based testing among stakeholders. By doing so, it encourages broader use of the framework in practical applications while gradually overcoming institutional, cultural, and technical barriers. Additionally, establishing a clear roadmap for mainstreaming the fish invitrome will help identify and address challenges to its uptake, ensuring a smoother transition to non-organismal testing methodologies.
Ključne besede:new approach methodologies (NAMs), rainbow trout cell lines, toxicity testing, socio-technical approach, co-design with stakeholders, ekotoksikologija
Status publikacije:V tisku
Verzija publikacije:Recenzirani rokopis
Leto izida:2025
PID:20.500.12556/DiRROS-21441 Novo okno
UDK:502/504
ISSN pri članku:0730-7268
DOI:10.1093/etojnl/vgaf028 Novo okno
COBISS.SI-ID:224893443 Novo okno
Opomba:Soavtorji: Ksenia Groh, Jessica Bertoli, Mihai-Ovidiu Degeratu, Melanie Fischer, Stephan Fischer, Jarno Hoekman, Barbara Jozef, Roman Li, Sven Lukas Mosimann, Colette vom Berg, Anže Županič, Bernhard Truffer, Kristin Schirmer; Online first: 28 Jan. 2025; Članek v PDF formatu obsega 40 str.;
Datum objave v DiRROS:03.02.2025
Število ogledov:50
Število prenosov:18
Metapodatki:XML DC-XML DC-RDF
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Gradivo je del revije

Naslov:Environmental toxicology and chemistry
Skrajšan naslov:Environ. toxicol. chem.
Založnik:Pergamon
ISSN:0730-7268
COBISS.SI-ID:26796032 Novo okno

Gradivo je financirano iz projekta

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:J4-3097-2021
Naslov:Molekularni mehanizmi odgovorni za zmanjšano rast ribjih celic zaradi izpostavljenosti kemikalijam

Financer:SNSF - Swiss National Science Foundation
Številka projekta:407940_206439
Naslov:Advancing 3R – Animals, Research and Society
Akronim:NRP 79

Financer:Drugi - Drug financer ali več financerjev
Program financ.:Lead Agency Project Grant jointly funded by the Slovenian Research Agency (ARIS) and the Swiss National Science Foundation (SNSF)
Številka projekta:205321_197327

Financer:Drugi - Drug financer ali več financerjev
Program financ.:CRACK IT Challenge “SAFE”
Številka projekta:NC/C021203/01

Licence

Licenca:CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc/4.0/deed.sl
Opis:Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:sistemska toksikologija, alternative eksperimentom na živalih, mavrična postrv, ekotoksikologija


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