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Title:Synthesis, purification, and cell-toxicity of a choline betainate
Authors:ID Jurko, Lucija (Author)
ID Hostnik, Gregor (Author)
ID Steindorfer, Tobias Alexander (Author)
ID Štern, Alja (Author)
ID Bošković, Perica (Author)
ID Bračič, Matej (Author)
ID Žegura, Bojana (Author)
ID Kargl, Rupert (Author)
Files:.pdf PDF - Presentation file, download (3,60 MB)
MD5: F137BF01D4EA39F4FFE15311D3926E37
 
URL URL - Source URL, visit https://doi.org/10.1016/j.molstruc.2024.138581
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo NIB - National Institute of Biology
Abstract:In this work, choline chloride and betaine hydrochloride were condensed into a - to our knowledge - unreported choline betainate (N,N,N-trimethyl-2-oxo-2-(2-(trimethylammonio)ethoxy)ethanaminium chloride) using 1,1′-carbonyldiimidazole (CDI) activation of betaine hydrochloride in dimethylsulfoxide. The product and reaction intermediates were isolated, purified by preparative HPLC and analyzed in detail by infrared and nuclear magnetic resonance spectroscopy. The final product has a high cytotoxicity for L929 mouse fibroblasts, and low antibacterial activity against P. Aeruginosa and S. Aureus at concentrations of up to 20 mg/ml. It could potentially further be investigated for similar uses as suxamethonium chloride, a muscle relaxant drug.
Keywords:choline chloride, betaine hydrochloride, carbonyldiimidazole, HPLC, antimicrobial, cytotoxicity
Publication status:Published
Publication version:Version of Record
Publication date:15.09.2024
Year of publishing:2024
Number of pages:[16] str.
Numbering:[article no.] 138581
PID:20.500.12556/DiRROS-20183 New window
UDC:577:576
ISSN on article:1872-8014
DOI:10.1016/j.molstruc.2024.138581 New window
COBISS.SI-ID:195589379 New window
Note:Nasl. z nasl. zaslona; Soavtorji: Gregor Hostnik , Tobias Steindorfer, Alja Štern, Perica Bošković, Matej Bračič, Bojana Žegura, Rupert Kargl; In Press, Journal pre-proof; Opis vira z dne 16. 5. 2024;
Publication date in DiRROS:07.08.2024
Views:523
Downloads:435
Metadata:XML DC-XML DC-RDF
:
JURKO, Lucija, HOSTNIK, Gregor, STEINDORFER, Tobias Alexander, ŠTERN, Alja, BOŠKOVIĆ, Perica, BRAČIČ, Matej, ŽEGURA, Bojana and KARGL, Rupert, 2024, Synthesis, purification, and cell-toxicity of a choline betainate. Journal of molecular structure [online]. 2024. Vol. 138581. [Accessed 21 April 2025]. DOI 10.1016/j.molstruc.2024.138581. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=20183
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Record is a part of a journal

Title:Journal of molecular structure
Publisher:Elsevier
ISSN:1872-8014
COBISS.SI-ID:23076101 New window

Document is financed by a project

Funder:EC - European Commission
Project number:764713
Name:A Training Network on Designing Novel Bio-based Fibre Products for Targeted Advanced Properties and New Applications
Acronym:FibreNet
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0245-2019
Name:Ekotoksiologija, toksikološka genomika in karcinogeneza

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Language:Slovenian
Keywords:molekularna biologija, holin klorid, betain hidroklorid, karbonildiimidazol, protimikrobnost, cititoksičnost


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