| Naslov: | Editorial : The role of immune cells in the progression of autoimmune diseases affecting the CNS |
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| Avtorji: | ID Kowal, Czeslawa (Avtor)
ID Pohar, Jelka (Avtor)
ID Zavala, Flora (Avtor) |
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| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://doi.org/10.3389/fimmu.2022.1078396
 PDF - Predstavitvena datoteka, prenos (296,08 KB)
MD5: EA7E27988E82BF86C1644A0F122656BD
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.03 - Drugi znanstveni članki |
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| Organizacija: |  NIB - Nacionalni inštitut za biologijo
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| Povzetek: | Insights into the dynamics of immune responses in immune-privileged tissues such as the central nervous system (CNS) are critical to understanding the etiology of autoimmune diseases. Essential in this field is understanding the ways immune cells access and traffic across different types of the blood-brain barrier (BBB), and how the therapeutics alter these processes (see excellent review by Mapunda et al.). The current Research Topic brought into attention a diverse panel of original research papers and two reviews on the immune cells involved in CNS pathophysiology, including dendritic cells (DC), mucosal-associated invariant T (MAIT) cells, neutrophils, and pathogenic Th17 cells, as well as a different aspects of that pathophysiology, including molecular signaling pathways (PP2Cδ) and the role of signaling complexes, known as supramolecular organizing centers (SMOCs), therapeutic interventions (STAT3-specific nanobody, treatment of rheumatoid meningitis with intravenous immunoglobulin - IVIg), possible new forms of autoantigens (neutrophil extracellular traps (NETs) in neuropsychiatric systemic lupus erythematosus - NPSLE), and assessment of correlation between inflammatory markers and severity of autoimmune encephalitis (AE). |
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| Ključne besede: | CNS pathophysiology, dendritic cells, mucosal-associated invariant T cells, STAT3, Th17 cells, PP2Cδ, supramolecular organizing centers (SMOCs), neutrophil extracellular traps, cytology |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 09.11.2022 |
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| Leto izida: | 2022 |
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| Št. strani: | str. 1-3 |
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| Številčenje: | Vol. 13 |
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| PID: | 20.500.12556/DiRROS-20158  |
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| UDK: | 576 |
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| ISSN pri članku: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2022.1078396 |
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| COBISS.SI-ID: | 131046403 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 25. 11. 2022;
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| Datum objave v DiRROS: | 06.08.2024 |
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| Število ogledov: | 276 |
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| Število prenosov: | 116 |
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| Metapodatki: |    |
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