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Naslov:Building and applying quantitative adverse outcome pathway models for chemical hazard and risk assessment
Avtorji:ID Perkins, Edward J. (Avtor)
ID Ashauer, Roman (Avtor)
ID Burgoon, Lyle (Avtor)
ID Conolly, Rory (Avtor)
ID Landesmann, Brigitte (Avtor)
ID Mackay, Cameron (Avtor)
ID Murphy, Cheryl A. (Avtor)
ID Pollesch, Nathan (Avtor)
ID Wheeler, James R. (Avtor)
ID Županič, Anže (Avtor)
ID Scholz, Stefan (Avtor)
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (1,11 MB)
MD5: 0FB8C8A6E6066099D4F1F09A38731B45
 
URL URL - Izvorni URL, za dostop obiščite https://doi.org/10.1002/etc.4505
 
Jezik:Angleški jezik
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:Logo NIB - Nacionalni inštitut za biologijo
Povzetek:An important goal in toxicology is the development of new ways to increase the speed, accuracy, and applicability of chemical hazard and risk assessment approaches. A promising route is the integration of in vitro assays with biological pathway information. We examined how the adverse outcome pathway (AOP) framework can be used to develop pathway-based quantitative models useful for regulatory chemical safety assessment. By using AOPs as initial conceptual models and the AOP knowledge base as a source of data on key event relationships, different methods can be applied to develop computational quantitative AOP models (qAOPs) relevant for decision making. A qAOP model may not necessarily have the same structure as the AOP it is based on. Useful AOP modeling methods range from statistical, Bayesian networks, regression, and ordinary differential equations to individual-based models and should be chosen according to the questions being asked and the data available. We discuss the need for toxicokinetic models to provide linkages between exposure and qAOPs, to extrapolate from in vitro to in vivo, and to extrapolate across species. Finally, we identify best practices for modeling and model building and the necessity for transparent and comprehensive documentation to gain confidence in the use of qAOP models and ultimately their use in regulatory applications. Environ Toxicol Chem 2019;38:1850–1865. © 2019 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC.
Ključne besede:Quantitative Adverse Outcome pathways, TKTD modelling, alternatives to animal testing, predictive toxicology, species extrapolation, prioritization of chemicals
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.09.2019
Leto izida:2019
Št. strani:str. 1850-1865
Številčenje:Vol. 38, no. 9
PID:20.500.12556/DiRROS-20127 Novo okno
UDK:577
ISSN pri članku:0730-7268
DOI:10.1002/etc.4505 Novo okno
COBISS.SI-ID:5093455 Novo okno
Datum objave v DiRROS:06.08.2024
Število ogledov:397
Število prenosov:248
Metapodatki:XML DC-XML DC-RDF
:
PERKINS, Edward J., ASHAUER, Roman, BURGOON, Lyle, CONOLLY, Rory, LANDESMANN, Brigitte, MACKAY, Cameron, MURPHY, Cheryl A., POLLESCH, Nathan, WHEELER, James R., ŽUPANIČ, Anže in SCHOLZ, Stefan, 2019, Building and applying quantitative adverse outcome pathway models for chemical hazard and risk assessment. Environmental toxicology and chemistry [na spletu]. 2019. Vol. 38, no. 9, p. 1850–1865. [Dostopano 6 april 2025]. DOI 10.1002/etc.4505. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=20127
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Gradivo je del revije

Naslov:Environmental toxicology and chemistry
Skrajšan naslov:Environ. toxicol. chem.
Založnik:Pergamon
ISSN:0730-7268
COBISS.SI-ID:26796032 Novo okno

Gradivo je financirano iz projekta

Financer:Drugi - Drug financer ali več financerjev
Program financ.:SETAC and partners

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

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