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Naslov:Brain malignancies : glioblastoma and brain metastases
Avtorji:ID Lah Turnšek, Tamara (Avtor)
ID Novak, Metka (Avtor)
ID Breznik, Barbara (Avtor)
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (1,83 MB)
MD5: B1330184488A239C9EC3031345F82644
 
URL URL - Izvorni URL, za dostop obiščite https://doi.org/10.1016/j.semcancer.2019.10.010
 
Jezik:Angleški jezik
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:Logo NIB - Nacionalni inštitut za biologijo
Povzetek:Brain, the major organ of the central nervous system controls and processes most of body activities. Therefore, the most aggressive brain tumor – glioblastoma and metastases from other organs to the brain are lethal leaving the patients with very short time of survival. The brain tissue landscape is very different from any other tissues and the specific microenvironment, comprising stem cells niches and blood-brain barrier, significantly influences the low rate of glioblastoma metastasis out of the brain, but better accommodates brain-invading cancer. In contrast to low frequency (0.5%) of all glioblastoma metastases, 10%–45% of other primary cancers do metastasize to the brain. This review addresses general cellular and molecular pathways that are to some extent similar in both types of metastases, involving circulating tumor cells (CTCs) with cancer stem cells (CSCs) characteristics, and metastatic niches. The invasion is a dynamic process involving reversible epithelial-to-mesenchymal (EMT) cell process, creating a transient gradient state that is inter-connected with epigenetic plasticity of the metastasizing (m)CSCs. These cells can switch between stationary, low proliferating/dormant state to a migratory, mesenchymal-like state. Settling in their respective niches as dormant CSCs in the secondary organ is a common feature in all types of metastases. In glioblastoma metastasis, the malignant mGSC cells express markers of mesenchymal GSC subtype (MES-GSC), such as CD44 and YK-40 and their major obstacle seems to be propagating in the in various organs’ microenvironments, different from the niches that home GSCs in the primary glioblastoma. Focusing on one stromal component in the glioblastoma niches, the mesenchymal stem cells (MSCs), we report herein on their differential effects on glioblastoma cells, highly depending on their genetic subtype. On the other hand, in brain metastases, the major hindrance to metastatic progression of mCSCs seem to be crossing the blood-brain-barrier. Novel therapeutic approaches for brain metastases from various cancer types are advancing slowly, and the general trends involve targeting metastatic sub-clones and selective determinants of their niches. The update on the four most common brain metastases from lung, breast, melanoma and colorectal carcinoma is presented.
Ključne besede:glioblastoma, cancer stem cells, invasion, metastasis, tumor microenvironment
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.02.2020
Leto izida:2020
Št. strani:str. 262-273
Številčenje:Vol. 60
PID:20.500.12556/DiRROS-20116 Novo okno
UDK:577.2
ISSN pri članku:1044-579X
DOI:10.1016/j.semcancer.2019.10.010 Novo okno
COBISS.SI-ID:5208399 Novo okno
Datum objave v DiRROS:06.08.2024
Število ogledov:581
Število prenosov:334
Metapodatki:XML DC-XML DC-RDF
:
LAH TURNŠEK, Tamara, NOVAK, Metka in BREZNIK, Barbara, 2020, Brain malignancies : glioblastoma and brain metastases. Seminars in cancer biology [na spletu]. 2020. Vol. 60, p. 262–273. [Dostopano 6 april 2025]. DOI 10.1016/j.semcancer.2019.10.010. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=20116
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Gradivo je del revije

Naslov:Seminars in cancer biology
Skrajšan naslov:Semin. cancer biol.
Založnik:Saunders Scientific Publications
ISSN:1044-579X
COBISS.SI-ID:1316372 Novo okno

Gradivo je financirano iz projekta

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:P1-0245-2019
Naslov:Ekotoksiologija, toksikološka genomika in karcinogeneza
Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:Z3-1870-2019
Naslov:Vpliv mezenhimskih matičnih celic na odpornost glioblastoma na terapijo
Financer:Drugi - Drug financer ali več financerjev
Naslov:Cross-Border Cooperation for Slovenia-Italy Interreg TRANS-GLIOMA

Licence

Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
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