| Naslov: | Stress-tolerant yeasts : opportunistic pathogenicity versus biocontrol potential |
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| Avtorji: | ID Zajc, Janja (Avtor)
ID Gostinčar, Cene (Avtor)
ID Černoša, Anja (Avtor)
ID Gunde-Cimerman, Nina (Avtor) |
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| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://www.mdpi.com/2073-4425/10/1/42
 PDF - Predstavitvena datoteka, prenos (2,70 MB)
MD5: 1AC46D46BEF413EDBCB4438E32FD3656
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  NIB - Nacionalni inštitut za biologijo
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| Povzetek: | Stress-tolerant fungi that can thrive under various environmental extremes are highly desirable for their application to biological control, as an alternative to chemicals for pest management. However, in fungi, the mechanisms of stress tolerance might also have roles in mammal opportunism. We tested five species with high biocontrol potential in agriculture (Aureobasidium pullulans, Debayomyces hansenii, Meyerozyma guilliermondii, Metschnikowia fructicola, Rhodotorula mucilaginosa) and two species recognized as emerging opportunistic human pathogens (Exophiala dermatitidis, Aureobasidium melanogenum) for growth under oligotrophic conditions and at 37 °C, and for tolerance to oxidative stress, formation of biofilms, production of hydrolytic enzymes and siderophores, and use of hydrocarbons as sole carbon source. The results show large overlap between traits desirable for biocontrol and traits linked to opportunism (growth under oligotrophic conditions, production of siderophores, high oxidative stress tolerance, and specific enzyme activities). Based on existing knowledge and these data, we suggest that oligotrophism and thermotolerance together with siderophore production at 37 °C, urease activity, melanization, and biofilm production are the main traits that increase the potential for fungi to cause opportunistic infections in mammals. These traits should be carefully considered when assessing safety of potential biocontrol agents. |
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| Ključne besede: | opportunistic pathogen, biocontrol agent, virulence, stress tolerance, secretome, CAZy, protease, thermotolerance, oligotrophism, melanin, siderophore, biofilm |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 14.01.2019 |
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| Leto izida: | 2019 |
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| Št. strani: | str. 1-23 |
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| Številčenje: | Vol. 10, no. 1 |
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| PID: | 20.500.12556/DiRROS-19576  |
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| UDK: | 579 |
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| ISSN pri članku: | 2073-4425 |
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| DOI: | 10.3390/genes10010042 |
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| COBISS.SI-ID: | 4966223 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 21. 1. 2019;
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| Datum objave v DiRROS: | 23.07.2024 |
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| Število ogledov: | 317 |
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| Število prenosov: | 241 |
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| Metapodatki: |    |
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