| Naslov: | Premalignant gastric lesions in patients included in National colorectal cancer screening |
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| Avtorji: | ID Tepeš, Bojan (Avtor)
ID Šeruga, Maja (Avtor)
ID Vujasinović, Miroslav (Avtor)
ID Urlep, Dejan (Avtor)
ID Ljepovic, Liljana (Avtor)
ID Brglez Jurecic, Nataša (Avtor)
ID Forte, Alenka (Avtor)
ID Kek-Ljubec, Anita (Avtor)
ID Skvarč, Miha (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (318,07 KB)
MD5: 295742E08CE538BC68B44DA473995A0C
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  OI - Onkološki inštitut Ljubljana
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| Povzetek: | Background. Gastric cancer is the fifth most common malignancy in the world with almost one million new cases annually. Helicobacter pylori infection causes 89% of all gastric cancers. Premalignant lesions (atrophy and intestinal metaplasia) develop after several decades of inflammation. Secondary prevention with gastroscopy is possible, but it is costly and has a low compliance rate. Alternative procedures like serology testing for pepsinogen I and II and pepsinogen I/II ratio are available to select patients for surveillance gastroscopies. Patients and methods. In seven outpatient endoscopic units, 288 patients (154 men; 53.5%), average age 60.68 years, tested positive in National colorectal cancer screening programme SVIT, were included in the study. Gastropanel (BioHit, Finland) was used as a serologic biopsy method. Results. We found 24 patients (12 men, mean age 63.7 years) with pepsinogen (pepsinogen I/II < 3 and/or pepsinogen I < 30 %g/L). Premalignant changes were found on gastric biopsies in 21 patients (7.3% incidence). Operative Link on Gastric Intestinal Metaplasia Assessment (OLGIM) % 1 was found in 20 patients; Operative Link for Gastritis Assessment (OLGA) % 1 was found in 19 patients. Combined accuracy for preneoplastic lesions in Gastropanel positive patients was 87.5%. H. pylori seropositivity was found in 219 patients (76%). Only 24% of our population had normal results. Conclusions. Gastropanel test has proven to be a reliable non-invasive test for advanced gastric preneoplastic lesions that can select patients for further gastroscopy. We found high H. pylori seropositivity in older age groups in Slovenia. |
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| Ključne besede: | Helicobacter pylori, gastropanel, atrophy, Slovenia, intestinal metaplasia, gastric cancer, SVIT |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 01.01.2018 |
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| Založnik: | Association of Radiology and Oncology |
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| Leto izida: | 2018 |
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| Št. strani: | str. 7-13, I |
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| Številčenje: | Vol. 52, no. 1 |
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| Izvor: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-19163  |
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| UDK: | 616.3 |
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| ISSN pri članku: | 1318-2099 |
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| DOI: | 10.1515/raon-2017-0054 |
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| COBISS.SI-ID: | 93861121 |
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| Avtorske pravice: | by Authors |
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| Opomba: | Soavtorji: Maja Seruga, Miroslav Vujasinovic, Dejan Urlep, Liljana Ljepovic, Jurecic Nataša Brglez, Alenka Forte, Ljubec Anita Kek, Miha Skvarc;
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| Datum objave v DiRROS: | 02.07.2024 |
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| Število ogledov: | 394 |
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| Število prenosov: | 123 |
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| Metapodatki: |    |
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