| Naslov: | Dynamic susceptibility contrast enhanced (DSC) MRI perfusion and plasma cytokine levels in patients after tonic-clonic seizures |
|---|
| Avtorji: | ID Filipovič, Tatjana (Avtor)
ID Šurlan Popović, Katarina (Avtor)
ID Ihan, Alojz (Avtor)
ID Vodušek, David B. (Avtor) |
|---|
| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://www.degruyter.com/view/j/raon.ahead-of-print/raon-2017-0031/raon-2017-0031.xml?format=INT
 PDF - Predstavitvena datoteka, prenos (676,20 KB)
MD5: 399DB82E770D109DF7C21F5736647CA4
|
|---|
| Jezik: | Angleški jezik |
|---|
| Tipologija: | 1.01 - Izvirni znanstveni članek |
|---|
| Organizacija: |  OI - Onkološki inštitut Ljubljana
|
|---|
| Povzetek: | Background Inflammatory events in brain parenchyma and glial tissue are involved in epileptogenesis. Blood concentration of cytokines is shown to be elevated after tonic-clonic seizures. As a result of inflammation, blood-brain barrier leakage occurs. This can be documented by imaging techniques, such is dynamic susceptibility contrast enhanced (DSC) MRI perfusion. Our aim was to check for postictal brain inflammation by studying DSC MRI perfusion and plasma level of cytokines. We looked for correlations between number and type of introducing seizures, postictal plasma level of cytokines and parameters of DSC MRI perfusion. Furthermore, we looked for correlation of those parameters and course of the disease over one year follow up. Patients and methods We prospectively enrolled 30 patients, 8%24 hours after single or repeated tonic-clonic seizures. Results 25 of them had normal perfusion parameters, while 5 had hyperperfusion. Patients with hyperperfusion were tested again, 3 months later. Two of 5 had hyperperfusion also on control measurements. Number of index seizures negatively correlated with concentration of proinflammatory cytokines IL-10, IFN-[gamma] and TNF-[alpha] in a whole cohort. In patients with hyperperfusion, there were significantly lower concentrations of antiinflammatory cytokine IL-4 and higher concentrations of proinflammatory TNF-[alpha]. Conclusions Long lasting blood- brain barrier disruption may be crucial for epileptogenesis in selected patients. |
|---|
| Ključne besede: | cytokines, blood-brain barrier, tonic-clonic seizures |
|---|
| Status publikacije: | Objavljeno |
|---|
| Verzija publikacije: | Objavljena publikacija |
|---|
| Datum objave: | 01.09.2017 |
|---|
| Založnik: | Association of Radiology and Oncology |
|---|
| Leto izida: | 2017 |
|---|
| Št. strani: | str. 277-285, IV |
|---|
| Številčenje: | Vol. 51, no. 3 |
|---|
| Izvor: | Ljubljana |
|---|
| PID: | 20.500.12556/DiRROS-19034  |
|---|
| UDK: | 616.8 |
|---|
| ISSN pri članku: | 1318-2099 |
|---|
| DOI: | 10.1515/raon.2017.0031 |
|---|
| COBISS.SI-ID: | 33377753 |
|---|
| Avtorske pravice: | by Authors |
|---|
| Opomba: | Soavtorji: Katarina Surlan Popovic, Alojz Ihan, David Bozidar Vodusek;
|
|---|
| Datum objave v DiRROS: | 03.06.2024 |
|---|
| Število ogledov: | 438 |
|---|
| Število prenosov: | 269 |
|---|
| Metapodatki: |    |
|---|
|
:
|
Kopiraj citat |
|---|
| | | | Objavi na: |  |
|---|
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše
podrobnosti ali sproži prenos. |
