Digitalni repozitorij raziskovalnih organizacij Slovenije

Izpis gradiva
A+ | A- | Pomoč | SLO | ENG

Naslov:Long-term outcomes of high dose treatment and autologous stem cell transplantation in follicular and mantle cell lymphomas : a single centre experience
Avtorji:ID Boltežar, Lučka (Avtor)
ID Pintarić, Karlo (Avtor)
ID Pretnar, Jože (Avtor)
ID Pohar Perme, Maja (Avtor)
ID Jezeršek Novaković, Barbara (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://www.degruyter.com/view/j/raon.ahead-of-print/raon-2016-0040/raon-2016-0040.xml
 
.pdf PDF - Predstavitvena datoteka, prenos (470,81 KB)
MD5: 41E9FB07A98A0E27387C86DA6F7DF53A
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:Background. Advanced follicular lymphoma (FL) and mantle cell lymphoma (MCL) are incurable diseases with conventional treatment. The high dose treatment (HDT) with autologous stem cell transplantation (ASCT), however, offers a certain proportion of these patients the prospect of a prolonged disease-free and overall survival. The aim of this study was to investigate the event free survival (EFS) and overall survival (OS) in patients with FL and MCL treated with ASCT. Patients and methods. Seventeen patients with FL and 29 patients with MCL were included, 15 of them were trans- planted to consolidate the response to second line treatment and 24 to consolidate their first remission, respectively. All were conditioned with total body irradiation (TBI) and high dose cyclophosphamide between 2006 and 2014 and all were transplanted with peripheral blood stem cells. Results. The estimated 5-year OS for FL was 87.8% (95% confidence interval [CI] 59.5%-96.8%) and for MCL 79.3% (95% CI 56.1%-91.1%), respectively. The estimated 5-year EFS for FL was 76.0% (95% CI 48.0%-90.3%) and for MCL 69.8% (95% CI 45.5%-84.8%), respectively. There were no secondary hematological malignancies observed in either group. Conclusions. Based on above results, the ASCT with TBI is a good treatment option in terms of long-term survival for patients with follicular and mantle cell lymphoma demonstrating a relatively low rate of late toxicities and secondary malignancies.
Ključne besede:follicular lymphoma, mantle cell lymphoma, autologous stem cell transplantation
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.03.2017
Založnik:Association of Radiology and Oncology
Leto izida:2017
Št. strani:str. 81-87, VIII
Številčenje:Vol. 51, no. 1
Izvor:Ljubljana
PID:20.500.12556/DiRROS-19027 Novo okno
UDK:616-006
ISSN pri članku:1318-2099
DOI:10.1515/raon-2016-0040 Novo okno
COBISS.SI-ID:32754393 Novo okno
Avtorske pravice:by Authors
Opomba:Soavtorji: Karlo Pintaric, Jože Pretnar, Maja Pohar Perme, Barbara Jezersek Novakovic;
Datum objave v DiRROS:03.06.2024
Število ogledov:95
Število prenosov:76
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
:
Kopiraj citat
  
Objavi na:Bookmark and Share


Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše podrobnosti ali sproži prenos.

Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:folikularni limfom, limfom plaščnih celic, avtologna presaditev matičnih celic


Nazaj