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Naslov:Compensational role between cathepsins
Avtorji:ID Pečar Fonović, Urša (Avtor)
ID Kos, Janko, Institut Jožef Stefan (Avtor)
ID Mitrović, Ana, Institut Jožef Stefan (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://www.sciencedirect.com/science/article/pii/S0300908424000853?via%3Dihub
 
.pdf PDF - Predstavitvena datoteka, prenos (730,45 KB)
MD5: AA95D8DD6EC3EBC07FD8DFA8B78AA5FC
 
Jezik:Angleški jezik
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:Logo IJS - Institut Jožef Stefan
Povzetek:Cathepsins, a family of lysosomal peptidases, play a crucial role in maintaining cellular homeostasis by regulating protein turnover and degradation as well as many specific regulatory actions that are important for proper cell function and human health. Alterations in the activity and expression of cathepsins have been observed in many diseases such as cancer, inflammation, neurodegenerative disorders, bone remodelling-related conditions and others. These changes are not exclusively harmful, but rather appear to be a compensatory response on the lack of one cathepsin in order to maintain tissue integrity. The upregulation of specific cathepsins in response to the inhibition or dysfunction of other cathepsins suggests a fine-tuned system of proteolytic balance and understanding the compensatory role of cathepsins may improve therapeutic potential of cathepsin's inhibitors. Selectively targeting one cathepsin or modulating their activity could offer new treatment strategies for a number of diseases. This review emphasises the need for comprehensive research into cathepsin biology in the context of disease. The identification of the specific cathepsins involved in compensatory responses, the elucidation of the underlying molecular mechanisms and the development of targeted interventions could lead to innovative therapeutic approaches.
Ključne besede:lysosomal peptidases, compensation, bone resorption
Status publikacije:V tisku
Verzija publikacije:Recenzirani rokopis
Poslano v recenzijo:03.04.2024
Datum sprejetja članka:22.04.2024
Založnik:Elsevier
Leto izida:2024
Št. strani:str. 1-51
Številčenje:Vol. , [article no.]
Izvor:Nizozemska
PID:20.500.12556/DiRROS-18979 Novo okno
UDK:577
ISSN pri članku:1638-6183
DOI:10.1016/j.biochi.2024.04.010 Novo okno
COBISS.SI-ID:193579011 Novo okno
Avtorske pravice:©2024TheAuthors.
Opomba:Nasl. z nasl. zaslona; Opis vira z dne 23. 4. 2024;
Datum objave v DiRROS:23.05.2024
Število ogledov:90
Število prenosov:83
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Biochimie
Skrajšan naslov:Biochimie
Založnik:Ed. scientifiques et médicales Elsevier
ISSN:1638-6183
COBISS.SI-ID:193576195 Novo okno

Gradivo je financirano iz projekta

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:J3-3071
Naslov:Katepsina B in X v tumorskih matičnih celicah raka dojke – molekulske tarče in pomen za protitumorno terapijo

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:P4-0127
Naslov:Farmacevtska biotehnologija: znanost za zdravje

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Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
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