| Naslov: | First experience with a novel luminescence-based optical sensor for measurement of oxygenation in tumors |
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| Avtorji: | ID Jarm, Tomaž (Avtor)
ID Lešničar, Hotimir (Avtor)
ID Serša, Gregor (Avtor)
ID Miklavčič, Damijan (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (231,19 KB)
MD5: E15409B69E537940419664C275388EEC
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  OI - Onkološki inštitut Ljubljana
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| Povzetek: | Background. The purpose of this preliminary study was to evaluate a novel luminescence-based fiber-optic sensor (OxyLite system) for the measurement of partial pressure of oxygen (pO2) in tumors and for the detection of changes inpO2 as a function of time. The new method was used simultaneously with the laser Doppler flowmetry method for the measurement of relative tissue perfusion. Materials and methods. Blood perfusion and pO2 were measured continuously via fiber-optic sensors inserted into SA-1 tumors in anesthetizedAžJ mice. The changes in blood flow and oxygenation of tumors wereinduced by transient changes of the parameters of anesthesia and by injection of a vasoactive drug hydralazine. Results. Both optical methods usedin the study successfully detected the induced changes in blood flow and pO2. The measurements of pO2 were well correlated with measurements of microcirculatory blood perfusion. In the majority of pO2 measurements, we observed an unexpected behavior of the signal during the stabilization processimmediately after the insertion of the probe into tumor. This behaviourof the pO2 signal was most probably caused by local tissue damage induced by the insertion of the probe. Conclusion. The novel luminescence-based optical oximetry can reliably detect local pO2 changes in tumors as a function of time but some aspects of prolonged pO2 measurement by this method require further investigation. |
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| Ključne besede: | sarcoma experimental, blood supply, laser-doppler flowmetry, oxygen, luminiscence |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 01.12.2001 |
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| Založnik: | Slovenian Medical Association - Slovenian Association of Radiology, Nuclear Medicine Society, Slovenian Society far Radiotherapy and Oncology, and Slovenian Cancer Society |
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| Leto izida: | 2001 |
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| Št. strani: | str. 277-291 |
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| Številčenje: | Vol. 35, no. 4 |
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| Izvor: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-17992  |
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| UDK: | 616-006 |
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| ISSN pri članku: | 1318-2099 |
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| COBISS.SI-ID: | 2531156 |
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| Avtorske pravice: | by Authors |
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| Datum objave v DiRROS: | 25.01.2024 |
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| Število ogledov: | 264 |
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| Število prenosov: | 79 |
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| Metapodatki: |     |
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