| Naslov: | Phase II study of fluorouracil, leucovorin and interferon alpha-2a in patients with advanced colon cancer |
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| Avtorji: | ID Štabuc, Borut (Avtor)
ID Markovič, Aleksandra (Avtor)
ID Brecelj, Erik (Avtor)
ID Bešlija, Samir (Avtor)
ID Cizej, Tomaž-Edvard (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (430,62 KB)
MD5: 58856A4E1508055CCBEF80ECE1D6A0EE
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  OI - Onkološki inštitut Ljubljana
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| Povzetek: | Based on in viro studies that have demonstrated synergy between fluorouracil (5-FU) and leucovorin (LV) as well as between 5-FU and recombinant alpha-2a interferon (IFN) against colon cancer cell lines a phase II study was carried out to evaluate the toxicity and clinical activity of 5-FU modulated with LV and IFN in patients with metastatic colon cancer. Twenty-two chemotherapy naive patients with measurable metastases of colon cancer have been treated with daily doses of 5-FU 600 mg/m2 in 6-hr intravenous infusion, and of LV 20 mg/m2 intravenously and IFN 6 MU subcutaneously, for 5 days every 4 weeks. Median age was 60 years, median PS (ECOG) was 1 (range 0-2). Liver, soft tissue and lung metastases were found in 12, 5 and 8 patients, respectively. Nineteen patients had a single metastatic site, two double, whereas one had more than two metastatic sites. Patients had 2-9 (mean 5) cycles of treatment.Objective response was observed in 7 patients (32%), and stable disease in 7 patients (32%). Overall median survival was 12.5 months, and for responders 14.4 months. Responses were generally short and median time for progression was 5.5 months. The most frequent adverse reactions were flu-like syndrome (50%), nausea/vomiting (36%), diarhoea (13Č), stomatitis (27%) and leucopenia (13%). This regimen of 5-FU with LV and IFN administration does notappear to be superior to previously published shedules of 5-FU with IFN or 5-FU with LV. |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 01.01.1998 |
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| Založnik: | Slovenian Medical Society - Section of Radiology ; Croatian Medical Association - Croatian Society of Radiology |
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| Leto izida: | 1998 |
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| Št. strani: | str. 407-415 |
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| Številčenje: | Letn. 32, št. 4 |
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| Izvor: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-17899  |
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| UDK: | 616-006 |
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| ISSN pri članku: | 1318-2099 |
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| COBISS.SI-ID: | 8142809 |
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| Avtorske pravice: | by Authors |
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| Opomba: | BSDOCID40579;
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| Datum objave v DiRROS: | 19.01.2024 |
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| Število ogledov: | 491 |
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| Število prenosov: | 129 |
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| Metapodatki: |    |
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