| Naslov: | The effects of topical antibiotics on eradication and acquisition of third-generation cephalosporin and carbapenem-resistant Gram-negative bacteria in ICU patients : ǂa ǂpost hoc analysis from a multicentre cluster-randomized trial |
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| Avtorji: | ID Plantinga, Nienke L. (Avtor)
ID Wittekamp, Bastiaan H. (Avtor)
ID Tomič, Viktorija, Klinika Golnik (Z enoto povezano ime)
ID Šifrer, Franc, Klinika Golnik (Z enoto povezano ime)
ID Brun-Buisson, Christian (Avtor)
ID Bonten, Marc J. M. (Avtor)
ID Tomič, Viktorija (Sodelavec pri raziskavi)
ID Šifrer, Franc (Sodelavec pri raziskavi) |
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| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://www.clinicalmicrobiologyandinfection.com/action/showPdf?pii=S1198-743X%2819%2930440-9
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
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| Povzetek: | Objectives: The aim was to quantify the effects of selective digestive tract decontamination (SDD) consisting of a mouth paste and gastro-enteral suspension, selective oropharyngeal decontamination with a mouth paste (SOD) and 1-2% chlorhexidine (CHX) mouthwash on eradication and acquisition of carriage of third-generation cephalosporin-resistant Enterobacterales (3GCR-E) and carbapenem-resistant Gram-negative bacteria (CR-GNB) in Intensive Care Unit (ICU) patients. Methods: This was a nested cohort study within a cluster-randomized cross-over trial in six European countries and 13 ICUs with 8665 patients. Eradication and acquisition during ICU stay of 3GCR-E and CRGNB were investigated separately in the rectum and respiratory tract for the three interventions and compared with standard care (SC) using Cox-regression competing events analyses. Results: Adjusted cause specific hazard ratios (CSHR) for eradication of rectal carriage for SDD were 1.76 (95% CI 1.31-2.36) for 3GCR-E and 3.17 (95% CI 1.60-6.29) for CR-GNB compared with SC. For the respiratory tract, adjusted CSHR for eradication of 3GCR-E were 1.47 (0.98-2.20) for SDD and 1.38 (0.92-2.06) for SOD compared with SC, and for eradication of CR-GNB these were 0.77 (0.41-1.45) for SDD and 0.81 (0.44-1.51) for SOD, compared with SC. Adjusted CSHRs for acquisition of rectal carriage during SDD (compared with SC) were 0.51 (0.40-0.64) for 3GCR-E and of 0.56 (0.40-0.78) for CR-GNB. Adjusted CSHRs for acquiring respiratory tract carriage with 3GCR-E compared with SC were 0.38 (0.28-0.50) for SDD and 0.55 (0.42-0.71) for SOD, and for CR-GNB 0.46 (0.33-0.64) during SDD and 0.60 (0.44-0.81) during SOD, respectively. SOD was not associated with eradication or acquisition of 3GCR-E and CR-GNB in the rectum. Conclusions: Among mechanically ventilated ICU patients, SDD was associated with more eradication and less acquisition of 3GCR-E and CR-GNB in the rectum than SC. SDD and SOD were associated with less acquisition of both 3GCR-E and CR-GNB than SC in the respiratory tract. |
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| Ključne besede: | intensive care units -- analysis -- epidemiology, bacterial drug resistance, anti-infective agents -- therapeutic use decontamination, beta-lactamases, Gram-negative bacteria, gastrointestinal tract -- microbiology -- drug therapy, cohort studies, colonization, ESBL, digestive tract |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Kraj izida: | Velika Britanija |
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| Založnik: | Elsevier |
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| Leto izida: | 2020 |
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| Št. strani: | str. 485-491 |
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| Številčenje: | Vol. 26, iss. 4 |
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| PID: | 20.500.12556/DiRROS-15121  |
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| UDK: | 579 |
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| ISSN pri članku: | 1469-0691 |
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| DOI: | 10.1016/j.cmi.2019.08.001 |
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| COBISS.SI-ID: | 2048615537 |
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| Avtorske pravice: | © 2019 European Society of Clinical Microbiology and Infectious Disease |
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| Opomba: | Sodelavca pri raziskavi iz Slovenije: Viktorija Tomič, Franc Šifrer;
Nasl. z nasl. zaslona;
Opis vira z dne 15. 1. 2020;
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| Datum objave v DiRROS: | 27.05.2022 |
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| Število ogledov: | 906 |
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| Število prenosov: | 339 |
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| Metapodatki: |    |
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