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Naslov:Neural bases of age-related sensorimotor slowing in the upper and lower limbs
Avtorji:ID Marušič, Uroš (Avtor)
ID Peskar, Manca (Avtor)
ID De Pauw, Kevin (Avtor)
ID Omejc, Nina (Avtor)
ID Drevenšek, Gorazd (Avtor)
ID Rojc, Bojan (Avtor)
ID Pišot, Rado (Avtor)
ID Kavcic, Voyko (Avtor)
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (2,66 MB)
MD5: D216E55CE584DDB481284B3DBAAECB03
 
URL URL - Izvorni URL, za dostop obiščite https://doi.org/10.3389/fnagi.2022.819576
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo ZRS Koper - Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria
Povzetek:With advanced age, there is a loss of reaction speed that may contribute to an increased risk of tripping and falling. Avoiding falls and injuries requires awareness of the threat, followed by selection and execution of the appropriate motor response. Using event-related potentials (ERPs) and a simple visual reaction task (RT), the goal of our study was to distinguish sensory and motor processing in the upper- and lower-limbs while attempting to uncover the main cause of age-related behavioral slowing. Strength (amplitudes) as well as timing and speed (latencies) of various stages of stimulus- and motor-related processing were analyzed in 48 healthy individuals (young adults, n = 24, mean age = 34 years; older adults, n = 24, mean age = 67 years). The behavioral results showed a significant age-related slowing, where the younger compared to older adults exhibited shorter RTs for the upper- (222 vs. 255 ms; p = 0.006, respectively) and the lower limb (257 vs. 274 ms; p = 0.048, respectively) as well as lower variability in both modalities (p = 0.001). Using ERP indices, age-related slowing of visual stimulus processing was characterized by overall larger amplitudes with delayed latencies of endogenous potentials in older compared with younger adults. While no differences were found in the P1 component, the later components of recorded potentials for visual stimuli processing were most affected by age. This was characterized by increased N1 and P2 amplitudes and delayed P2 latencies in both upper and lower extremities. The analysis of motor-related cortical potentials (MR) revealed stronger MRCP amplitude for upper- and a non-significant trend for lower limbs in older adults. The MRCP amplitude was smaller and peaked closer to the actual motor response for the upper- than for the lower limb in both age groups. There were longer MRCP onset latencies for lower- compared to upper-limb in younger adults, and a non-significant trend was seen in older adults. Multiple regression analyses showed that the onset of the MRCP peak consistently predicted reaction time across both age groups and limbs tested. However, MRCP rise time and P2 latency were also significant predictors of simple reaction time, but only in older adults and only for the upper limbs. Our study suggests that motor cortical processes contribute most strongly to the slowing of simple reaction time in advanced age. However, late-stage cortical processing related to sensory stimuli also appears to play a role in upper limb responses in the elderly. This process most likely reflects less efficient recruitment of neuronal resources required for the upper and lower extremity response task in older adults.
Ključne besede:aging, sensoriomotor integration, event-related potential, finger and foot responses, motor-related cortical potential
Leto izida:2022
Št. strani:str. 1-13
Številčenje:Vol. 14 , art. 819576
UDK:612.66:796.012.1
ISSN pri članku:1663-4365
DOI:10.3389/fnagi.2022.819576 Novo okno
COBISS.SI-ID:106449923 Novo okno
Avtorske pravice:© 2022 Marusic, Peskar, De Pauw, Omejc, Drevensek, Rojc, Pisot and Kavcic
Opomba:Nasl. z nasl. zaslona; Soavtorji: Manca Peskar, Kevin De Pauw, Nina Omejc, Gorazd Drevensek, Bojan Rojc, Rado Pisot, Voyko Kavcic; Opis vira z dne 4. 5. 2022;
Datum objave v DiRROS:04.05.2022
Število ogledov:108
Število prenosov:113
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Gradivo je del revije

Naslov:Frontiers in aging neuroscience
Skrajšan naslov:Front. aging neurosci.
Založnik:Frontiers Research Foundation
ISSN:1663-4365
COBISS.SI-ID:20576008 Novo okno

Gradivo je financirano iz projekta

Financer:EC - European Commission
Številka projekta:952401
Naslov:TWINning the BRAIN with machine learning for neuro-muscular efficiency
Akronim:TwinBrain

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P5-0381
Naslov:Kineziologija za kakovost življenja

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:03.05.2022

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