Digitalni repozitorij raziskovalnih organizacij Slovenije

Izpis gradiva
A+ | A- | SLO | ENG

Naslov:Hymenoptera venom immunotherapy : immune mechanisms of induced protection and tolerance
Avtorji:Demšar, Ajda (Avtor)
Korošec, Peter (Avtor)
Košnik, Mitja (Avtor)
Zidarn, Mihaela (Avtor)
Rijavec, Matija (Avtor)
Jezik:Angleški jezik
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:Logo UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
Povzetek:Hymenoptera venom allergy is one of the most severe allergic diseases, with a considerable prevalence of anaphylactic reaction, making it potentially lethal. In this review, we provide an overview of the current knowledge and recent findings in understanding induced immune mechanisms during different phases of venom immunotherapy. We focus on protection mechanisms that occur early, during the build-up phase, and on the immune tolerance, which occurs later, during and after Hymenoptera venom immunotherapy. The short-term protection seems to be established by the early desensitization of mast cells and basophils, which plays a crucial role in preventing anaphylaxis during the build-up phase of treatment. The early generation of blocking IgG antibodies seems to be one of the main reasons for the lower activation of effector cells. Long-term tolerance is reached after at least three years of venom immunotherapy. A decrease in basophil responsiveness correlates with tolerated sting challenge. Furthermore, the persistent decline in IgE levels and, by monitoring the cytokine profiles, a shift from a Th2 to Th1 immune response, can be observed. In addition, the generation of regulatory T and B cells has proven to be essential for inducing allergen tolerance. Most studies on the mechanisms and effectiveness data have been obtained during venom immunotherapy (VIT). Despite the high success rate of VIT, allergen tolerance may not persist for a prolonged time. There is not much known about immune mechanisms that assure longterm tolerance post-therapy.
Ključne besede:allergy and immunology, hypersensitivity, immunotherapy, immune tolerance, venoms, Hymenoptera, Hymenoptera venom, short-term protection, long-term tolerance
Leto izida:2021
Založnik:MDPI
Izvor:Švica
UDK:616-097
ISSN pri članku:2073-4409
COBISS_ID:68017411 Povezava se odpre v novem oknu
DOI:10.3390/cells10071575 Povezava se odpre v novem oknu
Opombe:Nasl. z nasl. zaslona; Soavtorji: Peter Korošec, Mitja Košnik, Mihaela Zidarn, Matija Rijavec; Opis vira z dne 23. 6. 2022; Št. članka: 1575;
Število ogledov:290
Število prenosov:82
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://www.mdpi.com/2073-4409/10/7/1575/pdf
 
Nadgradivo:Cells
MDPI
 
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Avtorske pravice:© 2021 by the authors
:
  
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše podrobnosti ali sproži prenos.


Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:22.06.2021

Nazaj