| Naslov: | Cold agglutinins and cryoglobulins associate with clinical and laboratory parameters of cold urticaria |
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| Avtorji: | ID Bizjak, Mojca, Klinika Golnik (Avtor)
ID Košnik, Mitja, Klinika Golnik, Medicinska fakulteta UL (Avtor)
ID Terhorst, Dorothea (Avtor)
ID Dinevski, Dejan (Avtor)
ID Maurer, Marcus (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (1,61 MB)
MD5: F74EA84224B9B6E2FFEB80EAD099B77D
PDF - Priloga, prenos (234,05 KB)
MD5: 0B8AADBC55EB371E4CD963613B958E11
 URL - Izvorni URL, za dostop obiščite https://www.frontiersin.org/articles/10.3389/fimmu.2021.665491/full
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
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| Povzetek: | Mast cell-activating signals in cold urticaria are not yet well defined and are likely to be heterogeneous. Cold agglutinins and cryoglobulins have been described as factors possibly associated with cold urticaria, but their relevance has not been explained. We performed a single-center prospective cohort study of 35 cold urticaria patients. Cold agglutinin and cryoglobulin test results, demographics, detailed history data, cold stimulation test results, complete blood count values, C-reactive protein, total immunoglobulin E levels, and basal serum tryptase levels were analyzed. Forty six percent (n = 16) of 35 tested patients had a positive cold agglutinin test and 27% (n = 9) of 33 tested patients had a positive cryoglobulin test. Cold agglutinin positive patients, when compared to cold agglutinin negative ones, were mainly female (P = 0.030). No gender-association was found for cryoglobulins. A positive cold agglutinin test, but not a positive cryoglobulin test, was associated with a higher rate of reactions triggered by cold ambient air (P = 0.009) or immersion in cold water (P = 0.041), and aggravated by increased summer humidity (P = 0.007). Additionally, patients with a positive cold agglutinin test had a higher frequency of angioedema triggered by ingestion of cold foods or drinks (P = 0.043), and lower disease control based on Urticaria Control Test (P = 0.023). Cold agglutinin levels correlated with erythrocyte counts (r = -0.372, P = 0.028) and monocyte counts (r = -0.425, P = 0.011). Cryoglobulin concentrations correlated with basal serum tryptase levels (r = 0.733, P = 0.025) and cold urticaria duration (r = 0.683, P = 0.042). Results of our study suggest that cold agglutinins and cryoglobulins, in a subpopulation of cold urticaria patients, are linked to the course and possibly the pathogenesis of their disease. |
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| Ključne besede: | urticaria, mast cells, cold-induced urticaria, cold urticaria, cryoglobulins, cold agglutinin, degranulation, clinical parameters, laboratory parameters |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Kraj izida: | Švica |
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| Založnik: | Frontiers Media SA |
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| Leto izida: | 2021 |
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| Št. strani: | str. 1-9 |
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| Številčenje: | [Vol.] 12 |
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| PID: | 20.500.12556/DiRROS-13941  |
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| UDK: | 616-097 |
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| ISSN pri članku: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2021.665491 |
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| COBISS.SI-ID: | 61629187 |
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| Avtorske pravice: | © 2021 Bizjak, Košnik, Terhorst-Molawi, Dinevski and Maurer |
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| Opomba: | Nasl. z nasl. zaslona;
Soavtorja iz Slovenije: Mitja Košnik, Dejan Dinevski;
Opis vira z dne 3. 5. 2021;
Št. prispevka: 665491;
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| Datum objave v DiRROS: | 10.05.2021 |
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| Število ogledov: | 1711 |
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| Število prenosov: | 1354 |
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| Metapodatki: |    |
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