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Naslov:Cold agglutinins and cryoglobulins associate with clinical and laboratory parameters of cold urticaria
Avtorji:Bizjak, Mojca (Avtor)
Košnik, Mitja (Avtor)
Terhorst, Dorothea (Avtor)
Dinevski, Dejan (Avtor)
Maurer, Marcus (Avtor)
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
Povzetek:Mast cell-activating signals in cold urticaria are not yet well defined and are likely to be heterogeneous. Cold agglutinins and cryoglobulins have been described as factors possibly associated with cold urticaria, but their relevance has not been explained. We performed a single-center prospective cohort study of 35 cold urticaria patients. Cold agglutinin and cryoglobulin test results, demographics, detailed history data, cold stimulation test results, complete blood count values, C-reactive protein, total immunoglobulin E levels, and basal serum tryptase levels were analyzed. Forty six percent (n = 16) of 35 tested patients had a positive cold agglutinin test and 27% (n = 9) of 33 tested patients had a positive cryoglobulin test. Cold agglutinin positive patients, when compared to cold agglutinin negative ones, were mainly female (P = 0.030). No gender-association was found for cryoglobulins. A positive cold agglutinin test, but not a positive cryoglobulin test, was associated with a higher rate of reactions triggered by cold ambient air (P = 0.009) or immersion in cold water (P = 0.041), and aggravated by increased summer humidity (P = 0.007). Additionally, patients with a positive cold agglutinin test had a higher frequency of angioedema triggered by ingestion of cold foods or drinks (P = 0.043), and lower disease control based on Urticaria Control Test (P = 0.023). Cold agglutinin levels correlated with erythrocyte counts (r = -0.372, P = 0.028) and monocyte counts (r = -0.425, P = 0.011). Cryoglobulin concentrations correlated with basal serum tryptase levels (r = 0.733, P = 0.025) and cold urticaria duration (r = 0.683, P = 0.042). Results of our study suggest that cold agglutinins and cryoglobulins, in a subpopulation of cold urticaria patients, are linked to the course and possibly the pathogenesis of their disease.
Ključne besede:urticaria, mast cells, cold-induced urticaria, cold urticaria, cryoglobulins, cold agglutinin, degranulation, clinical parameters, laboratory parameters
Leto izida:2021
Založnik:Frontiers Media SA
Izvor:Švica
UDK:616-097
ISSN pri članku:1664-3224
COBISS_ID:61629187 Povezava se odpre v novem oknu
DOI:10.3389/fimmu.2021.665491 Povezava se odpre v novem oknu
Opombe:Nasl. z nasl. zaslona; Soavtorja iz Slovenije: Mitja Košnik, Dejan Dinevski; Opis vira z dne 3. 5. 2021; Št. prispevka: 665491;
Število ogledov:306
Število prenosov:270
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (1,61 MB)
.pdf PDF - Priloga, prenos (234,05 KB)
URL URL - Izvorni URL, za dostop obiščite https://www.frontiersin.org/articles/10.3389/fimmu.2021.665491/full
 
Nadgradivo:Front. immunol.
Frontiers Research Foundation
 
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Avtorske pravice:© 2021 Bizjak, Košnik, Terhorst-Molawi, Dinevski and Maurer
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Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:29.04.2021

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