Digitalni repozitorij raziskovalnih organizacij Slovenije

Izpis gradiva
A+ | A- | SLO | ENG

Naslov:Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma : an international multicenter study
Avtorji:Brčić, Luka (Avtor)
Klikovits, Thomas (Avtor)
Megyesfalvi, Zsolt (Avtor)
Mosleh, Berta (Avtor)
Sinn, Katharina (Avtor)
Hritcu, Richard (Avtor)
Laszlo, Viktoria (Avtor)
Čufer, Tanja (Avtor)
Rozman, Aleš (Avtor)
Kern, Izidor (Avtor)
Mohorčič, Katja (Avtor)
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
Povzetek:Background: Programmed cell death 1/programmed death ligand 1 (PD-1/PD-L1) immune-checkpoint blockade is a promising new therapeutic strategy in cancer. However, expression patterns and prognostic significance of PD-L1 and PD-1 are still controversial in human malignant pleural mesothelioma (MPM). Methods: Formalin-fixed paraffin-embedded (FFPE) tumor samples from 203 MPM patients receiving standard treatment without immunotherapy were collected from 5 European centers. PD-L1 and PD-1 expression of tumor cells (TCs) and tumor-infiltrating lymphocytes (TILs) were measured by immunohistochemistry and correlated with clinical parameters and long-term outcome. Results: High (>10%) PD-L1 TC and PD-1 TILs expressions were found in 18 (8%) and 39 (24%) patients, respectively. PD-L1 was rarely expressed by TILs [>/=1%, n=13 (8%); >10%, n=1]. No significant associations were found between the PD-L1 or PD-1 expression of TCs or TILs and clinicopathological parameters such as stage or histological subtype. Notably, patients with high (>10%) TC-specific PD-L1 expression exhibited significantly worse median overall survival (OS) (6.3 vs. 15.1 months of those with low TC PD-L1 expression; HR: 2.51, P<0.001). In multivariate cox regression analysis adjusted for clinical parameters, high TC PD-L1 expression (>10%) proved to be an independent negative prognostic factor for OS (HR: 2.486, P=0.005). There was no significant correlation between PD-L1 or PD-1 expression of TILs and OS. Conclusions: In this multicenter cohort study, we demonstrate that high (>10%) PD-L1 expression of TCs independently predicts worse OS in MPM. Further studies are warranted to investigate the value of PD-L1/PD-1 expression as a marker for treatment response in MPM patients receiving immunotherapy.
Ključne besede:mesothelioma - anatomy and histology - analysis, 1malignant pleural mesothelioma, programmed death-ligand 1, programmed cell death 1, PD-L1
Leto izida:2021
Založnik:AME Publishing
Izvor:Kitajska
UDK:616-006
ISSN pri članku:2226-4477
COBISS_ID:56719619 Povezava se odpre v novem oknu
DOI:10.21037/tlcr-20-1114 Povezava se odpre v novem oknu
Opombe:Nasl. z nasl. zaslona; Soavtorji iz Slovenije: Tanja Cufer, Ales Rozman, Izidor Kern, Katja Mohorcic; Opis vira z dne 22. 3. 2021;
Število ogledov:65
Število prenosov:24
Datoteke:URL URL - Predstavitvena datoteka, za dostop obiščite https://tlcr.amegroups.com/issue/publishAheadOfPrint
 
Nadgradivo:Transl. lung cancer res.
Pioneer Bioscience
 
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Avtorske pravice:© Translational Lung Cancer Research
:
  
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše podrobnosti ali sproži prenos.


Licence

Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Začetek licenciranja:28.01.2021

Nazaj