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Naslov:Cold urticaria : what we know and what we do not know
Avtorji:Maltseva, Natalya (Avtor)
Borzova, Elena (Avtor)
Fomina, Daria (Avtor)
Bizjak, Mojca (Avtor)
Terhorst, Dorothea (Avtor)
Košnik, Mitja (Avtor)
Kulthanan, Kanokvalai (Avtor)
Meshkova, Raisa (Avtor)
Thomsen, Simon Francis (Avtor)
Maurer, Marcus (Avtor)
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
Povzetek:Cold urticaria (ColdU) is a common form of chronic inducible urticaria characterised by the development of wheals, angioedema or both in response to cold exposure. Recent research and guideline updates have advanced our understanding and management of ColdU. Today, its pathophysiology is thought to involve the cold-induced formation of autoallergens and IgE to these autoallergens, which provoke a release of proinflammatory mediators from skin mast cells. The classification of ColdU includes typical and atypical subtypes. We know that cold-induced wheals usually develop on rewarming and resolve within an hour and that anaphylaxis can occur. The diagnosis relies on the patient's history and cold stimulation testing. Additional diagnostic work-up, including a search for underlying infections, should only be done if indicated by the patient's history. The management of ColdU includes cold avoidance, the regular use of nonsedating antihistamines, and the off-label use of omalizumab. However, many questions regarding ColdU remain unanswered. Here, we review what is known about ColdU, and we present important unanswered questions on the epidemiology, underlying pathomechanisms, clinical heterogeneity and treatment outcomes. Our aim is to guide future efforts that will close these knowledge gaps and advance the management of ColdU.
Ključne besede:urticaria, cryopyrin-associated periodic syndromes, cold-induced urticaria, familial cold autoinflammatory syndrome, cold stimulation testing, wheals, cryoglobulinemic vasculitis, cryoglobulins
Leto izida:2020
Založnik:John Wiley & Sons
Izvor:Velika Britanija
UDK:616-097
ISSN pri članku:1398-9995
OceCobissID:515009305 Povezava se odpre v novem oknu
COBISS_ID:41305859 Povezava se odpre v novem oknu
DOI:10.1111/all.14674 Povezava se odpre v novem oknu
Opombe:Nasl. z nasl. zaslona; Soavtorja iz Slovenije: Mojca Bizjak, Mitja Košnik; Opis vira z dne 7. 12. 2020;
Število ogledov:497
Število prenosov:166
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.14674
 
Nadgradivo:Allergy
Blackwell
 
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Avtorske pravice:© John Wiley & Sons
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