251. Unique structural features of mule deer prion protein provide insights into chronic wasting diseaseUrška Slapšak, Giulia Salzano, Gregor Ilc, Gabriele Giachin, Jifeng Bian, Glenn Telling, Giuseppe Legname, Janez Plavec, 2019, izvirni znanstveni članek Objavljeno v DiRROS: 24.11.2020; Ogledov: 1160; Prenosov: 787
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256. Uspevanje omorike (Picea omorika (Pančić) Purk.) v generativnem semenskem nasadu Počivalnik pri PostojniSebastian Bambič, Kristjan Jarni, Gregor Božič, Robert Brus, 2020, izvirni znanstveni članek Povzetek: Omorika (Picea omorika (Pančić) Purk.) je endemična drevesna vrsta z Balkanskega polotoka, ki dobro uspeva tudi v Sloveniji in bi bila na nekaterih rastiščih v manjših deležih lahko zanimiva alternativa navadni smreki (Picea abies (L.) Karst.). Raziskavo smo opravili v nasadu omorike pod vrhom hriba Počivalnik med Uncem in Postojno. Drevesa so bila posajena leta 1988 in so zdaj v fazi drogovnjaka. Izmerili smo jim prsni premer in ocenili zdravstveno stanje. Izračunali smo deleže dreves različnih zdravstvenih stanj za posamezne provenience in fenotipe, izdelali model nasada, napravili analizo variance in post hoc test. Ugotovili smo, da imajo provenience velik vpliv na vitalnost dreves, ne pa tudi na debelinski prirastek. Vitalnost dreves se prav tako razlikuje med posameznimi fenotipi. Korelacijo med fenotipi in prsnimi premeri smo potrdili pri dveh od petih fenotipov (B; tip 'semidichotomy', C; tip 'serbica'). Vpliv fenotipa na debelinski prirastek je v različnih proveniencah različen. Glede na našo raziskavo bi bil ob morebitni uporabi za Dinarski kras v Sloveniji najprimernejši semenski material provenience Šargan, najprimernejša fenotipa pa C (tip 'serbica') in F (tip 'argentea'), oba sicer najbolj zaželena tudi v hortikulturi.
Ključne besede: Picea omorika, provenienca, fenotip, vitalnost, ujma, pogozdovanje
Objavljeno v DiRROS: 18.11.2020; Ogledov: 6045; Prenosov: 1723
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257. Borova ogorčica, Bursaphelenchus xylophilus (Steiner & Buhrer, 1934) Nickle, 1970 - nova nevarnost za slovenske gozdove?Maja Jurc, Gregor Urek, Saša Širca, Vid Mikulič, Branko Glavan, 2003, pregledni znanstveni članek Povzetek: V prispevku obravnavamo borovo ogorčico (Bursaphelenchus xylophilus), ki je v Evropi (tudi v Sloveniji) uvrščena na karantensko listo A1. Vrsta je izredno napadalna, povzroča hitro propadanje iglavcev - predvsem vrst rodu Pinus, redko Picea, Abies in Larix. Prikazan je njen areal, ekološke zahteve, gostitelji, bionomija ter simptomi napada na borih. V okviru bionomije borove ogorčice so posebej predstavljeni njeni potrjeni vektorji (Insecta: Cerambycidae - rod Monochamus) in tudi njeni potencialni vektorji (Insecta: Curculionidae - rod Pissodes in Scolytidae). Podajamo razširjenost potencialnih gostiteljskih rastlin borove ogorčice pri nas, podnebne razmere ter kritične točke za vnos in širjenje škodljivca. Ocenjujemo stopnjo fitosanitarnega tveganja pojava borove ogorčice v Sloveniji.
Ključne besede: nematode, borova ogorčica, fitosanitarno tveganje, bionomija, iglavci, Slovenija
Objavljeno v DiRROS: 17.11.2020; Ogledov: 1372; Prenosov: 423
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258. Timeline of leaf and cambial phenology in relation to development of initial conduits in xylem and phloem in three coexisting sub-Mediterranean deciduous tree speciesJožica Gričar, Andreja Vedenik, Gregor Skoberne, Polona Hafner, Peter Prislan, 2020, izvirni znanstveni članek Povzetek: It is unclear how the anticipated climate change will affect the timing of phenology of different tree organs/tissues and thus the whole-tree functioning. We examined the timing of leaf phenology and secondary growth in three coexisting deciduous tree species (Quercus pubescens Willd., Fraxinus ornus L. and Ostrya carpinifolia Scop) from a sub-Mediterranean region in 2019. In addition, we investigated the relationship between leaf and cambial phenology and the onset of the potential functioning of initial conduits, as determined by the completed differentiation process (vessels) or final size (sieve tubes). For this purpose, leaf development was monitored and the microcores of cambium and the youngest phloem and xylem increments were repeatedly collected at 7-10-day intervals during the growing season. The results revealed differences in the timing of leaf development and seasonal radial growth patterns in spring among the studied tree species, depending on wood porosity. We found that cambial cell production started in all cases in the first half of March. However, in ring-porous Q. pubescens and F. ornus, radial growth in the stem occurred more than a month before buds were swollen, whereas in diffuse-porous O. carpinifolia, these two events were detected at almost the same time. The end of cambial cell production occurred earliest in F. ornus (mid-July) and two weeks later also in the other two species. The widest initial earlywood vessels and early phloem sieve tubes were found in Q. pubescens, the narrowest initial earlywood vessels in O. carpinifolia and the narrowest early phloem sieve tubes in F. ornus. This indicates differences in the e%ciency of conducting systems among the studied species. This novel approach of studying phloem phenology and anatomy in relation to leaf and xylem development contributes to a better understanding of how different tree species adapt their structure of secondary vascular tissues in response to environmental change.
Ključne besede: Quercus pubescens, Fraxinus ornus, Ostrya carpinifolia, earlywood, early phloem, vessel, sieve tube, radial growth
Objavljeno v DiRROS: 21.10.2020; Ogledov: 1277; Prenosov: 927
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259. Prevalence of and factors associated with healthcare-associated infections in Slovenian acute care hospitals : results of the third national surveyIrena Klavs, Mojca Serdt, Aleš Korošec, Tatjana Lejko-Zupanc, Blaž Pečavar, 2019, izvirni znanstveni članek Povzetek: Introduction. In the third Slovenian national healthcare-associated infections (HAIs) prevalence survey, conducted within the European point prevalence survey of HAIs and antimicrobial use in acute care hospitals, we estimated the prevalence of all types of HAIs and identified factors associated with them. Methods. Patients were enrolled into a one-day cross-sectional study in November 2017. Descriptive analyses were performed to describe the characteristics of patients, their exposure to invasive procedures and the prevalence of different types of HAIs. Univariate and multivariate analyses of association of having at least one HAI with possible risk factors were performed to identify risk factors. Results. Among 5,743 patients, 4.4% had at least one HAI and an additional 2.2% were still treated for HAIs on the day of the survey, with a prevalence of HAIs of 6.6%. The prevalence of pneumoniae was the highest (1.8%), followed by surgical site infections (1.5%) and urinary tract infections (1.2%). Prevalence of blood stream infections was 0.3%. In intensive care units (ICUs), the prevalence of patients with at least one HAI was 30.6%. Factors associated with HAIs included central vascular catheter (adjusted odds ratio [aOR] 4.1; 95% confidence intervals [CI]: 3.1–5.4), peripheral vascular catheter (aOR 3.0; 95% CI: 2.3–3.9), urinary catheter (aOR 1.8; 95% CI: 1.4–2.3). Conclusions. The prevalence of HAIs in Slovenian acute care hospitals in 2017 was substantial, especially in ICUs. HAIs prevention and control is an important public health priority. National surveillance of HAIs in ICUs should be developed to support evidence-based prevention and control.
Ključne besede: healthcare-associated infections, prevalence, survey, risk factors, Slovenia
Objavljeno v DiRROS: 16.10.2020; Ogledov: 2397; Prenosov: 892
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260. Expression of FGFR1-4 in malignant pleural mesothelioma tissue and corresponding cell lines and its relationship to patient survival and FGFR inhibitor sensitivityGregor Vlačić, Mir Alireza Hoda, Thomas Klikovits, Katharina Sinn, Elisabeth Gschwandtner, Katja Mohorčič, Karin Schelch, Christine Pirker, Barbara Peter-Vörösmarty, Jelena Brankovic, Tanja Čufer, Aleš Rozman, Izidor Kern, 2019, izvirni znanstveni članek Povzetek: Malignant pleural mesothelioma (MPM) is a devastating malignancy with limited therapeutic options. Fibroblast growth factor receptors (FGFR) and their ligands were shown to contribute to MPM aggressiveness and it was suggested that subgroups of MPM patients could benefit from FGFR-targeted inhibitors. In the current investigation, we determined the expression of all four FGFRs (FGFR1-FGFR4) by immunohistochemistry in tissue samples from 94 MPM patients. From 13 of these patients, we were able to establish stable cell lines, which were subjected to FGFR1-4 staining, transcript analysis by quantitative RT-PCR, and treatment with the FGFR inhibitor infigratinib. While FGFR1 and FGFR2 were widely expressed in MPM tissue and cell lines, FGFR3 and FGFR4 showed more restricted expression. FGFR1 and FGFR2 showed no correlation with clinicopathologic data or patient survival, but presence of FGFR3 in 42% and of FGFR4 in 7% of patients correlated with shorter overall survival. Immunostaining in cell lines was more homogenous than in the corresponding tissue samples. Neither transcript nor protein expression of FGFR1-4 correlated with response to infigratinib treatment in MPM cell lines. We conclude that FGFR3 and FGFR4, but not FGFR1 or FGFR2, have prognostic significance in MPM and that FGFR expression is not suffcient to predict FGFR inhibitor response in MPM cell lines.
Ključne besede: malignant pleural mesothelioma, fibroblast growth factor receptors, azbestos, immunotherapy, chemotherapy, genomic analysis, infigratinib
Objavljeno v DiRROS: 07.10.2020; Ogledov: 12138; Prenosov: 1029
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