1. Fine-tuning the nanostructured titanium oxide surface for selective biological responseNiharika Rawat, Metka Benčina, Domen Paul, Janez Kovač, Katja Lakota, Polona Žigon, Veronika Kralj-Iglič, Hsin-Chia Ho, Marija Vukomanović, Aleš Iglič, Ita Junkar, 2023, izvirni znanstveni članek Ključne besede: gaseous plasma treatment, hydrothermal treatment, biocompatibility, vascular stent, nanostructured surface
Objavljeno v DiRROS: 03.08.2026; Ogledov: 131; Prenosov: 114
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2. Correlation between sagittal balance and thoracolumbar elastic energy parameters in 42 spines subject to spondylolisthesis or spinal stenosis and 21 normal spinesŠpela Bračun, Anna Romolo, Veronika Rehakova, Jure Leban, Žan Pukšič, Rok Vengust, Matej Daniel, Veronika Kralj-Iglič, Mitja Drab, 2024, izvirni znanstveni članek Povzetek: The curvature of the lumbar spine plays a critical role in maintaining spinal function, stability, weight distribution, and load transfer. We have developed a mathematical model of the lumbar spine curve by introducing a novel mechanism: minimization of the elastic bending energy of the spine with respect to two biomechanical parameters: dimensionless lumbosacral spinal curvature ▫$c_{LS}$▫ and dimensionless curvature increment along the spine CI. While most of the biomechanical studies focus on a particular segment of the spine, the distinction of the presented model is that it describes the shape of the thoracolumbar spine by considering it as a whole (non-locally) and thus includes interactions between the different spinal levels in a holistic approach. From radiographs, we have assessed standard geometrical parameters: lumbar lordosis LL, pelvic incidence PI, pelvic tilt PT, sacral slope ▫$\psi_0$▫ and sagittal balance parameter SB = sagittal vertical axis (SVA)/sacrumbicoxofemoral distance (SFD) of 42 patients with lumbar spinal stenosis (SS) or degenerative spondylolisthesis (SL) and 21 radiologically normal subjects. SB statistically significantly correlated with model parameters ▫$c_{L5}$▫ (r = − 0.34, p = 0.009) and − CI (r = 0.33, p = 0.012) but not with standard geometrical parameters. A statistically significant difference with sufficient statistical power between the patients and the normal groups was obtained for ▫$c_{LS}$▫ , CI, and SB but not for standard geometrical parameters. The model provides a possibility to predict changes in the thoracolumbar spine shape in surgery planning and in assessment of different spine pathologies.
Ključne besede: lumbar lordosis, thoracolumbar spine, elastic energy, sagittal balance, spine curvature
Objavljeno v DiRROS: 09.06.2026; Ogledov: 234; Prenosov: 230
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3. Enhanced hemocompatibility and cytocompatibility of stainless steelMetka Benčina, Niharika Rawat, Domen Paul, Janez Kovač, Katja Lakota, Polona Žigon, Veronika Kralj-Iglič, Aleš Iglič, Ita Junkar, 2024, izvirni znanstveni članek Ključne besede: surface modifications, electrochemical anodization, non-thermal plasma treatment, altered surface properties, blood platelets, human coronary stents
Objavljeno v DiRROS: 03.06.2026; Ogledov: 235; Prenosov: 255
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4. Low preserved proximal femoral bone stock volume as a risk factor for periprosthetic femoral fractures : a study of 90 femursMatic Kolar, Blaž Mavčič, Veronika Kralj-Iglič, Vane Antolič, 2025, izvirni znanstveni članek Ključne besede: hip, osteoarthritis, total hip arthroplasty, periprosthetic fractures, bone stock
Objavljeno v DiRROS: 13.04.2026; Ogledov: 304; Prenosov: 190
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5. No short-term effects of acromioclavicular joint augmentation in acute acromioclavicular joint stabilization surgery : a randomized controlled clinical trial on 70 patientsMiha Ambrožič, Matej Cimerman, Kristjan Omahen, Martina Jaklič, Veronika Kralj-Iglič, Ladislav Kovačič, 2025, izvirni znanstveni članek Povzetek: Background: Optimal treatment for high-grade acromioclavicular (AC) joint dislocations is still not unanimous. Improving horizontal AC stability has been emphasized in recent years. Biomechanical studies and computer simulations have demonstrated that adequate horizontal stability could be restored with an additional AC fixation. We aim to prospectively investigate if AC augmentation leads to better clinical and radiological results. Methods: A total of 70 patients with a mean (±SD) age of 42 ± 11 years with acute AC joint dislocation Rockwood type IIIb and V were prospectively randomized into two equal groups. All patients underwent arthroscopically assisted stabilization using a double coracoclavicular (CC) suspensory system. Group N (No-augmentation group) had no additional fixation across the AC joint, while group T (tape-augmentation group) had additional fixation with tape. Patients were evaluated at 3, 6, and 12 months postoperatively. Primary clinical outcome measures included the Constant–Murley score and the Specific AC Score (SACS). Secondary outcome measures included the Subjective Shoulder Value (SSV), the Simple Shoulder Test (SST), the Disabilities of the Arm, Shoulder, and Hand (DASH) outcome measure, and the AC Joint Instability (ACJI) Score. Horizontal stability was radiologically measured with overlapping length (OL) and overlapping area (OA). Vertical alignment was measured with the CC distance. All radiological measurements were compared to the uninjured side and expressed in percentages as relative values. Results: There were no significant differences found between groups regarding the Constant score (p = 0.664), SACS (p = 0.518), or any other outcome measure at the one-year follow-up. Pain level (p = 0.635) and strength (p = 0.217) at the one-year mark also showed no significant differences. Clinical drawer testing for residual horizontal instability was non-significant (p = 0.061), but showed a tendency for a more stable AC joint in group T. The CC distance was smaller in group T at 6 and 12 months (p = 0.047 and p = 0.046, respectively). A two-way mixed factorial ANOVA test showed significantly lower CC differences for group T (p = 0.032); however, the gradual increase in CC distance was similar for both groups over time (p = 0.869). No significant differences were found in OL (p = 0.619) or OA (p = 0.236). Conclusions: The results of our study show that both CC stabilization with the double suspensory system alone and with additional AC fixation are effective surgical treatment options for acute AC joint dislocations, without any important clinical differences. CC distance similarly increased over one year in both groups but was better retained in the AC-augmented group, which showed a tendency toward a more stable fixation.
Ključne besede: acromioclavicular joint dislocation, horizontal acromioclavicular instability, acromioclavicular augmentation, overlapping length, overlapping area, coracoclavicular distance, arthroscopic assisted surgery
Objavljeno v DiRROS: 10.03.2026; Ogledov: 446; Prenosov: 331
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6. Enhancing the outcomes of temporalis fascia tympanoplasty using autologous platelet-rich plasma and gel : a randomized controlled trialNejc Steiner, Domen Vozel, Nina Božanić Urbančič, Kaja Troha, Andraž Lazar, Veronika Kralj-Iglič, Saba Battelino, 2025, izvirni znanstveni članek Ključne besede: tympanoplasty, platelet-rich plasma (PRP), platelet-rich gel (PRG), extracellular vesicles, tympanic membrane perforation, cartilage graft, hearing improvement, quality of life, randomized controlled trial, otologic surgery
Objavljeno v DiRROS: 19.02.2026; Ogledov: 501; Prenosov: 275
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7. Titanium nanostructures for biomedical applicationsMukta Vishwanath Kulkarni, Anca Mazare, Ekaterina Gongadze, Šárka Perutková, Veronika Kralj-Iglič, Ingrid Milošev, Patrik Schmuki, Aleš Iglič, Miran Mozetič, 2015, pregledni znanstveni članek Objavljeno v DiRROS: 20.05.2025; Ogledov: 819; Prenosov: 329
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8. The effect of different surfactants and polyelectrolytes on nano-vesiculation of artificial and cellular membranesUrška Zagorc, Darja Božič, Vesna Arrigler, Žiga Medoš, Matej Hočevar, Anna Romolo, Veronika Kralj-Iglič, Ksenija Kogej, 2024, izvirni znanstveni članek Ključne besede: extracellular vesicles, liposomes, surfactants, polyelectrolytes, static light scattering, dinamic light scattering, microcalorimetry, drug delivery, cell-to-cell communication
Objavljeno v DiRROS: 24.12.2024; Ogledov: 1214; Prenosov: 814
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9. Assessment of extracellular particles directly in diluted plasma and blood by interferometric light microscopy : a study of 613 human and 163 canine samplesBoštjan Korenjak, Armando Tratenšek, Matevž Arko, Anna Romolo, Matej Hočevar, Matic Kisovec, Maxence Berry, Apolonija Bedina Zavec, David Drobne, Tomaž Vovk, Aleš Iglič, Alenka Nemec Svete, Vladimira Erjavec, Veronika Kralj-Iglič, 2024, izvirni znanstveni članek Ključne besede: extracellular particles, extracellular vesicles, exosomes, membrane vesiculation, platelets, blood products, platelet-rich plasma, liquid biopsy, membrane enclosed, drug delivery
Objavljeno v DiRROS: 20.12.2024; Ogledov: 1266; Prenosov: 812
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10. The role of extracellular vesicles in phenotypic cancer transformationEva Ogorevc, Veronika Kralj-Iglič, Peter Veranič, 2013, pregledni znanstveni članek Povzetek: Background. Cancer has traditionally been considered as a disease resulting from gene mutations. New findings in biology are challenging gene-centered explanations of cancer progression and redirecting them to the non-genetic origins of tumorigenicity. It has become clear that intercellular communication plays a crucial role in cancer progression. Among the most intriguing ways of intercellular communication is that via extracellular vesicles (EVs). EVs are membrane structures released from various types of cells. After separation from the mother membrane, EVs become mobile and may travel from the extracellular space to blood and other body fluids. Conclusions. Recently it has been shown that tumour cells are particularly prone to vesiculation and that tumour-derived EVs can carry proteins, lipids and nucleic acids causative of cancer progression. The uptake of tumour-derived EVs by noncancerous cells can change their normal phenotype to cancerous. The suppression of vesiculation could slow down tumour growth and the spread of metastases. The purpose of this review is to highlight examples of EV-mediated cancer phenotypic transformation in the light of possible therapeutic applications.
Objavljeno v DiRROS: 03.04.2024; Ogledov: 1318; Prenosov: 909
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