41. Cysteine proteinase inhibitors stefin A and stefin B in operable carcinoma of the head and neck : Inhibitorji cisteinskih proteinaz stefin A in stefin B pri operabilnem karcinomu glave in vratuPrimož Strojan, Marjan Budihna, Alojz Šmid, Branka Svetic, Ivan Vrhovec, Janko Kos, Janez Škrk, 2002, izvirni znanstveni članek Povzetek: Purpose. To evaluate the significance of cysteine proteinase inhibitors stefins (Stefs) A and B for a treatment decision and prognosis in operable squamous cell carcinoma of the head and neck (SCCHN). Patients and methods. Stefs A and B concentrations were determined immunobiochemically using ELISAs in cytosols prepared from the tumor and adjacent normal mucosa from 91 patients with operable SCCHN. The median follow-up period of patients alive atthe close-out date was 5.8 years (range, 5-9.3 years). Results. Stef A concentrations were significantly higher in tumor compared to normal mucosa (FM.05). When a subgroup with clinically palpable nodes) at presentation was taken into consideration (n=57), a significant difference in Stef A (P=0.03) and Stef B (P=0.02) concentrations between those with negative and positive necks, as determined on histopathological examination, was observed. On the univariate survival analysis, higher Stefsć concentrations turned to be prognostically advantageous. Stef A proved its independent prognostic significance also on multivariate setting. Conclusions. With the capability todifferentiate between the pN0- and pN+-stages of the disease in the patientsoriginally presented as node-positive, Stefs A and B could be useful markers when deciding on the extent of neck surgery. In addition, both Stefs proved to be reliable prognosticators for survival in patients with operable SCCHN. Objavljeno v DiRROS: 31.01.2024; Ogledov: 149; Prenosov: 37 Celotno besedilo (114,91 KB) |
42. European project BRAPHYQSJanez Burger, 2002, strokovni članek Povzetek: Background. Quality assurance in radiotherapy and brachytherapy is extremely important because errors that may occur during treatment process can be fatal for the patient. European Society for Therapeutic Radiology and Oncology has therefore founded BRAPHYQS, a special group that is responsible for the revision of quality assurance procedures of treatment performed in brachytherapy centers and for outlining common standards of work in European countries. Conclusions. The project BRAPHYQS has the following aims: (1) to publish European recommendations for implementing QA/QC in European brachytherapy centers; (2) to set up a central dosimetry audit in European brachytherapy centers (this task will be delegated to ESTRO-EQUAL laboratory at the Institute Gustave Roussy in Paris); (3) to set up a central audit for the geometrical reconstruction of source positions with a special test phantomthat will be available to each brachytherapy center. Hence, a series of"Baltas phantoms" will be elaborated and distributed to the brachytherapy centers in Europe; (4) to prepare a draft of booklet of QA/QC recommendations for testing the brachytherapy equipment and therapy planning systems. Objavljeno v DiRROS: 31.01.2024; Ogledov: 135; Prenosov: 31 Celotno besedilo (67,75 KB) |
43. Metodologija za oceno stanja lesnopredelovalnega sektorja : tržni potenciali okroglega lesa v Sloveniji in njegova nadaljnja uporabaŠpela Ščap, Janez Zafran, Nike Krajnc, 2022, elaborat, predštudija, študija Ključne besede: gozdno-lesni sektor, gozdni lesni sortimenti, okrogli les, lesnopredelovalna panoga, zaloga ogljika v lesnih izdelkih Objavljeno v DiRROS: 31.01.2024; Ogledov: 144; Prenosov: 0 |
44. Fine particulate matter (PM2.5) exposure assessment among active daily commuters to induce behaviour change to reduce air pollutionAnja Ilenič, Alenka Mauko Pranjić, Nina Zupančič, Radmila Milačič, Janez Ščančar, 2023, izvirni znanstveni članek Povzetek: Fine particulate matter (PM2.5), a detrimental urban air pollutant primarily emitted by traffic and biomass burning, poses disproportionately significant health risks at relatively limited exposure during commuting. Previous studies have mainly focused on fixed locations when assessing PM2.5 exposure, while neglecting pedestrians and cyclists, who often experience higher pollution levels. In response, this research aimed to independently validate the effectiveness of bicycle-mounted low-cost sensors (LCS) adopted by citizens, evaluate temporal and spatial PM2.5 exposure, and assess associated health risks in Ljubljana, Slovenia. The LCS quality assurance results, verified by co-location field tests by air quality monitoring stations (AQMS), showed comparable outcomes with an average percentage difference of 21.29 %, attributed to humidity-induced nucleation effects. The colder months exhibited the highest air pollution levels (μ = 32.31 μg/m3) due to frequent thermal inversions and weak wind circulation, hindering vertical air mixing and the adequate dispersion of pollutants. Additionally, PM2.5 levels in all sampling periods were lowest in the afternoon (μ = 12.09 μg/m3) and highest during the night (μ = 61.00 μg/m3) when the planetary boundary layer thins, leading to the trapping of pollutants near the surface, thus significantly affecting diurnal and seasonal patterns. Analysis of exposure factors revealed that cyclists were approximately three times more exposed than pedestrians. However, the toxicological risk assessment indicated a minimal potential risk of PM2.5 exposure. The collaborative integration of data from official AQMS and LCS can enhance evidence-based policy-making processes and facilitates the realignment of effective regulatory frameworks to reduce urban air pollution. Ključne besede: air pollution monitoring, PM2.5 exposure, citizen science, bicycle-mounted low-cost sensors Objavljeno v DiRROS: 30.01.2024; Ogledov: 182; Prenosov: 73 Celotno besedilo (2,57 MB) Gradivo ima več datotek! Več... |
45. Evaluation and metrological performance of a novel ionisation vacuum gauge suitable as reference standardKarl Jousten, Sylke Bechstein, Matthias Bernien, Frédéric Boineau, N. Bundaleski, Claus Illgen, Berthold Jenninger, Janez Šetina, Ricardo A. S. Silva, Anke Stöltzel, O. M. N. D. Teodoro, Martin Wüest, 2023, izvirni znanstveni članek Ključne besede: ionisation vacuum gauge, hot cathode, sensitivity, secondary electrons, ion induced secondary electron yield Objavljeno v DiRROS: 26.01.2024; Ogledov: 212; Prenosov: 95 Celotno besedilo (3,39 MB) Gradivo ima več datotek! Več... |
46. High sensitivity measurements of gas transport through films for food packaging and the ▫$O_2$▫ adsorption issueMarine Schott, Janez Šetina, Espedito Vassallo, Matteo Pedroni, Roberta Campardelli, Patrizia Perego, Luca Repetto, Giuseppe Firpo, 2023, izvirni znanstveni članek Ključne besede: oxygen transmission rate, food packaging, gas permeability, O2adsorption Objavljeno v DiRROS: 26.01.2024; Ogledov: 179; Prenosov: 91 Celotno besedilo (2,56 MB) Gradivo ima več datotek! Več... |
47. Radical irradiation of the prostate. Combination of percutaneous irradiation and irradiation with LDR Ir-192 implantsBorut Kragelj, Franc Guna, Janez Burger, 2001, izvirni znanstveni članek Povzetek: Background. The irradiation of the carcinomas of the prostate with the doses above the tolerable ones of standard radiotherapy improves the local control of the disease. The aim of this study is to determine the acute toxicity and tolerability of the high-dose prostate irradiation combining external beam radiotherapy (EBRT) and interstitial low dose rate (LDR) brachyradiotherapy (BRT) Ir-192 of the prostate. Material and methods. We examined medical records of 8 patients with localized carcinoma of the prostate (T2-T3 No-x Mo)treated from August 1999 until February 2000. The initial PSA was 2.7-37.5 ng/ml (median 13.7) and Gleason score 4-9 (median 7). Radiotherapy consisted of 48.6-50.4 Gy of EBRT to the prostate and seminal vesicles (4 patients) or the whole pelvis (4 patients) and 20.0-28.0 Gy of interstital LDR Ir-192 BRT given as a single fraction, fluoroscopic guided transperineal Implantation of the prostate. The cumulative doses of percutaneous and interstitial irraditations to the prostate were 68.6 - 79.1 Gy. Results. Acute toxic effects of irradiation though observed in all patients were of only mild intensity. According to the RTOG criteria, 20/30 toxicities were assessed as grade 1, 9/30 as grade 2, and 1/30 as grade 3. In none of the patients, toxic effects required any specific modification of the treatment regimen. Conclusions. The very first experiences indicate moderate toxicity and optimaltolerance of the treatment by patients. An improvement of implantation techniques may be expected with regular CT controls of the implants and extra attentive care of the implants in the urethra region. Objavljeno v DiRROS: 25.01.2024; Ogledov: 170; Prenosov: 41 Celotno besedilo (223,53 KB) |
48. Factors influencing rehabilitation in patients with head and neck cancerIrena Hočevar-Boltežar, Alojz Šmid, Miha Žargi, Avgust Župevc, Igor Fajdiga, Janez Fischinger, Ana Jarc, 2000, izvirni znanstveni članek Povzetek: Purpose. The purpose of the prospective study was to identify the factors adversely influencing the post-treatment rehabilitation in patients with head and neck cancer. Patients and methods. One hundred and ten patients with oral cavity, pharyngeal and laryngeal cancer were examined before surgical treatment in order to find unfavorable factors: hearing loss, defective teeth,impaired pulmonary function, and speech disorders. The patients evaluated the success of their rehabilitation 12 months after the treatment. The influence of possible unfavorable factors, tumor site, and type of surgeryon speech, swallowing and reintegration competence was determinated. Results. The site of the tumor and the type of surgery did not influence the quality of rehabilitation in general. Defective teeth influenced the ability of swallowing but not the speech. Hearing loss impaired the patient's reintegration in their home environment. Impaired pulmonary function did not affect patient's speech. Speech was the poorest in laryngectomized patients. However, about two thirds of the patients were satisfied with their capabilityof speech, swallowing and their rehabilitation in general. Conclusions. Early identification of unfavorable factors, and individually planned rehabilitation can ensure a suitable quality of life for patients thathave undergone surgery for head and neck cancer. Objavljeno v DiRROS: 25.01.2024; Ogledov: 152; Prenosov: 43 Celotno besedilo (322,91 KB) |
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