1. Management of patients with protein s deficiency : focus on clinical course and direct oral anticoagulantNicola Altamura, Filippo Giorgio Di Girolamo, Paola Pradella, Martina Cavalet, Federica Pellicori, Pierandrea Vinci, Emiliano Panizon, Giovanni Cominotto, Kaja Teraž, Gianni Biolo, 2026, izvirni znanstveni članek Povzetek: Background Protein S (PS) is a cofactor of protein C (PC) which, when activated to activated PC (APC), mainly acts to degrade coagulation factor Va and VIIIa, and its deficiency may trigger an array of venous thromboembolic events (VTE); when unprovoked and life-threatening, these need indefinite anticoagulation. Direct oral anti coagulants (doac) are efficient drugs in therapy and prevention of VTE, although the optimal prophylactic doses in different conditions are not identified. Methods General characteristics and clinical events of 33 PS deficient patients (7 uneventful, 10 carrying also other thrombophilic conditions) were recorded from their medical records. Patients suffering from VTE underwent LMWH/Fondaparinux therapy followed by a full dose of doac (apixaban or rivaroxaban) and then a reduced dose doac (apixaban and rivaroxaban). Results Average, lowest and highest PS levels measured during follow-up were higher in male patients (p = 0.001). The cumulative prevalence of patients taking drugs acting on central nervous system (opioids, antidepressants, antiepileptic, antimigraine, antipsychotic) was 33%. Three minor hemorrhages were observed during the full-dose and one during the reduced doac therapy, while 3 VTE (1 pulmonary embolism and 2 deep venous thrombosis) occurred exclusively during the reduced-dose doac therapy (p = 0.033 Vs Full dose, 8.1 100patient/yr 95% CI 4–15). Compliance during the reduced-dose therapy was good according to the circulating levels of doac. In survival analysis, the only variable associated with VTE recurrence was PS deficiency combined with thrombophilic defects (p = 0.049). Conclusions Free PS deficiency affects the quality of life in many ways and a low dose doac in PS deficient patients is only partially effective in secondary prevention of VTE.
Ključne besede: thrombophilia, reduced-dose DOAC, bleeding, thromboembolic events
Objavljeno v DiRROS: 16.04.2026; Ogledov: 52; Prenosov: 30
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3. Mental - and temporal - demand NASA - task load Index scores correlate with decreases in irisin serum levels in healthy individuals subjected to 10-day bed restPatrizia Pignataro, Uroš Marušič, Roberta Zerlotin, Angela Oranger, Manuela Dicarlo, Clelia Suriano, Paolo Taurisano, Rado Pišot, Boštjan Šimunič, Marco Vincenzo Narici, 2026, izvirni znanstveni članek Povzetek: Background Bed rest (BR) is a widely used analogue of space flight that aims to replicate microgravity conditions, such as immobilization and a lack of sensorimotor stimuli. In a previous BR study, we evaluated the changes in irisin serum levels, a myokine produced mainly by skeletal muscle that exerts pleiotropic effects on several organs, including the brain. Objective Here, we evaluated whether the decline in circulating irisin concentrations during 10 days of horizontal BR correlated with the National Aeronautics and Space Administration Task Load Index (NASA-TLX). Methods NASA-TLX was obtained from young healthy participants at the end of the BR protocol. It is a self-report measure of task load that includes six subscales: mental demand, physical demand, temporal demand, performance, effort, and frustration. Each subscale score was correlated with the decline in serum irisin levels measured while participants were supine. Irisin decline was calculated as the difference between levels on the first day of BR (BR0) and the last day (BR9). Results Our results show a significant positive correlation between irisin decline and both mental demand and temporal demand, whereas correlations with the remaining subscales showed a positive association with irisin decline but did not reach statistical significance. Conclusion These findings suggest that reduced irisin levels are associated with increased perceived mental demand and time pressure (temporal demand) during BR. Because temporal demand can exacerbate high mental activity in a state of cognitive overload, maintaining higher circulating irisin levels could represent an effective countermeasure to improve the cognitive performance of participants during future BR studies and may help astronauts manage mental and temporal pressure during space missions.
Ključne besede: bed rest, microgravity, irisin, cognitive performance, NASA-TLX indeks
Objavljeno v DiRROS: 09.04.2026; Ogledov: 63; Prenosov: 40
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4. Characteristics of poor elderly people in the early 19th century included in the system of formal care – the case of the provincial centre of LjubljanaDragica Čeč, 2026, samostojni znanstveni sestavek ali poglavje v monografski publikaciji Povzetek: Newer approaches to the analysis of old age, shaped by the cultural turn, emphasise the individual’s perspective and the experience of ageing “from below.” An examination of the life trajectories of applicants for poor relief in Ljubljana confirms the hypotheses that elderly people combined various sources of subsistence and sought to maintain independence, yet those who entered the system of formal care were generally physically weak and almost invariably without a kin network that could support them. Nevertheless, some applicants possessed a highly developed social network. The analysis shows that in the context under study, old age was not understood as a chronological category but primarily as a matter of work capacity, physical strength, and the ability to support oneself.
Ključne besede: poor-relief, old age, gender differences, economy of makeshifts, 19th century, Ljubljana
Objavljeno v DiRROS: 31.03.2026; Ogledov: 134; Prenosov: 82
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5. Images of old age in the paintings of Ivana KobilicaTomislav Vignjević, 2026, samostojni znanstveni sestavek ali poglavje v monografski publikaciji Povzetek: This paper explores a wide range of depictions and preparatory studies of elderly figures within the artistic oeuvre of the Slovenian painter Ivana Kobilca (1861–1926). In the middle of the second half of the 19th century, she created a series of physiognomic studies of old people, which confirmed and highlighted her mastery of a realistic pictorial language, which was in many respects determined by the painting principles of Leibl’s Munich circle. In this concentration on psychological expression and realism, her work differs greatly from that of other Slovenian artists of the time, who most often visualised anecdotal genre depictions of the elderly. The paper thus highlights and analyses the exceptional importance of this group of paintings of elderly people that Kobilca created in the 1880s and 1890s.
Ključne besede: old age, realism, painting, genre, portrait, Ivana Kobilica
Objavljeno v DiRROS: 31.03.2026; Ogledov: 90; Prenosov: 64
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6. The burden of ageing : old age, poverty, and attitudes toward social issues in the 19th-century Austrian LittoralUrška Bratož, 2026, samostojni znanstveni sestavek ali poglavje v monografski publikaciji Povzetek: The paper examines attitudes toward ageing and the elderly in Istria and Trieste in the second half of the nineteenth century. It takes as its starting point the perceptions associated with old age, which in the nineteenth century inevitably included, on the one hand, the inability to work—often leading to the economic dependence of the elderly and to their being regarded as a burden on the family or the state—and, on the other hand, their physical frailty, whether biologically or socially conditioned, which could to some extent be both a cause and a symptom of their social deprivation. Elderly people can be traced among the residents of almshouses and recipients of poor relief, among patients in hospitals for infectious diseases, and among those who died of age related wasting. Medical imperatives directed at the elderly were tailored primarily to the bourgeoisie and stood in stark contrast to the actual experience of ageing among the lower classes, which could not be associated with rest and self care but rather with prolonged physical labour, bodily pain, and economic insecurity.
Ključne besede: diseases, old age, mortality, poverty, social measures, Trieste, Istria, 19th century
Objavljeno v DiRROS: 31.03.2026; Ogledov: 129; Prenosov: 84
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8. Jeziki ob meji kot temelj sodelovanja, zaupanja in skupnega razvojaVesna Mikolič, Irina Moira Cavaion, Maša Rolih, Diana Košir, 2026, poljudni članek Ključne besede: raziskovanje, raziskovalne organizacije, razvoj, Valovi znanja, Znanstveno-raziskovalno središče Koper
Objavljeno v DiRROS: 27.03.2026; Ogledov: 161; Prenosov: 57
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