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4. Sistemsko zdravljenje : hematološki raki – kaj je preseglo pričakovanja?Barbara Jezeršek Novaković, Rozala Arko, 2026, objavljeni strokovni prispevek na konferenci Povzetek: Čeprav se je preživetje bolnikov s hematološkimi malignomi v zadnjih treh desetletjih podaljšalo na račun zdravljenj s konvencionalno sistemsko terapijo in presaditvijo krvotvornih matičnih celic, se bolezen pri številnih bolnikih kljub zdravljenju ponovi. Nadaljnje povečevanje intenzivnosti tovrstnega zdravljenja onemogočata tako prehuda toksičnost uporabljenih zdravil kot tudi že doseženi plato njihove učinkovitosti, zaradi česar obstaja stalna zahteva po novih, učinkovitejših, manj toksičnih in bolj usmerjenih terapevtskih pristopih. Takšne terapije predstavljajo tarčna zdravljenja in novi imunoterapevtski pristopi. Od leta 2016 naprej je področje sistemskega zdravljenja hematoloških rakov (levkemije, limfomi, multipli mielom) doživelo nekaj prebojev, ki niso le izboljšali izidov – v določenih podskupinah bolnikov so dejansko presegli pričakovanja, tudi v smislu “funkcionalnega ozdravljenja” pri sicer neozdravljivih boleznih.
Ključne besede: onkologija, sistemsko zdravljenje, hematologija
Objavljeno v DiRROS: 03.06.2026; Ogledov: 109; Prenosov: 56
 Celotno besedilo (270,55 KB) |
5. Acute ischemic stroke trends in Slovenia, 2015-2022 : declining admissions, rising reperfusion, uneven gainsTjaša Furlan, Borut Jug, Neža Nograšek, Dalibor Gavrić, Janja Pretnar-Oblak, Petra Došenović Bonča, Senta Frol, 2026, izvirni znanstveni članek Povzetek: ntroduction: We assessed nationwide trends in administratively identified ischaemic stroke admissions, pro- cedures, secondary prevention, and outcomes in Slovenia using linked national datasets in the absence of a dedicated stroke registry. Methods: We conducted a nationwide longitudinal analysis of adult hospital admissions captured in linked administrative databases between 2015 and 2022. We report crude index-admission rates, acute procedures (intravenous thrombolysis [IVT], mechanical thrombectomy [MT], carotid thromboendarterectomy [CEA], ca- rotid artery angioplasty with stenting [CAS]), discharge secondary-prevention prescriptions, and time-to-death analyses with a maximum follow-up of 5 years. Results: We included 16,839 unique index patients (median age 74 years; 54% male). Admissions peaked in 2017 (2169) and crude rates decreased from 105 to 99 per 100,000 residents by 2022. Revascularisation increased (IVT 6.2% to 15%, MT 5.4% to 9.5%, CEA 9.1% to 14%), length of stay decreased, and discharge prevention therapy improved. Five-year mortality was higher with age and comorbidity and lower among patients receiving IVT and several secondary-prevention therapies. Care pathways differed by stroke aetiology; women were older and men underwent more CAS and CEA, while IVT and MT were similar. Conclusion: Crude admissions declined modestly while reperfusion and prevention improved, but the magnitude and pattern of improvement differed by care domain and patient subgroup, supporting continued monitoring and the development of a national stroke registry.
Ključne besede: Slovenija, zdravje, bolezni, kap, zdravljenje, trendi
Objavljeno v DiRROS: 02.06.2026; Ogledov: 192; Prenosov: 95
Celotno besedilo (1,25 MB) |
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