1. A numerical study of gas focused non-Newtonian micro-jetsRizwan Zahoor, Saša Bajt, Božidar Šarler, 2024, izvirni znanstveni članek Ključne besede: serial crystallography, micro jets, multiphase flow, fluid rheology, non-Newtonian fluid, flow focusing
Objavljeno v DiRROS: 28.02.2024; Ogledov: 134; Prenosov: 66
 Celotno besedilo (11,78 MB)
Gradivo ima več datotek! Več... |
2. Influence of hydralazine on interstitial fluid pressure in experimental tumors - a preliminary study : Vpliv hydralazina na tlak medcelične tekočine v poskusnih tumorjihBlaž Podobnik, Damijan Miklavčič, 2000, izvirni znanstveni članek Povzetek: Background. Interstitial fluid pressure (IFP) has been recognised as the most important obstacle in macromolecular drug delivery to solid tumors. Our interest was to reduce differentialy tumor IFP with respect to IFP in surrounding and normal tissues in order to increase drug delivery to tumors aswell to increase tumor blood flow and potentialy tumor tissue oxygenation. In this preliminary study we used hydralazine, a longacting arterial vasodilator. Materials and methods. Measurements of interstitial fluid pressure were performed in vivo on CBA mice bearing SAF tumors using wick-in-needle technigue. Altogether eleven measurements were obtained on different animals with tumors of different size. Results. IFP in tumors after hydralazine administration was significantly lower than initial values in corresponding tumors. On average tumor IFP decreased for 33 % from initial value. On the contrary, no change in IFP in normal tissue was observed after hydralazine administration. Also, after injection of physiological saline instead of hydralazine there was no change in IFP neither in tumors nor in muscle. The results of our preliminary study on the effect of hydralazine on IFP in SAF tumor model is in accordance to previously reported studies. The decrease in tumor IFP was only observed in tumors, but not in muscle and surrounding subcutis. Conclusion. Hydralazine is a vasodilator which is capable of decreasing tumor IFP, reproducibly and with favorably long lasting dynamics.
Ključne besede: sarcoma, experimental drug therapy, hydralazine, extracellular space, interstitial fluid pressure, manometry
Objavljeno v DiRROS: 23.01.2024; Ogledov: 196; Prenosov: 50
Celotno besedilo (497,71 KB) |
3. Residual stress modeling and analysis in AISI A2 steel processed by an electrical discharge machineDinesh Kumar, Krishan Kant Singh Mer, Hoshiyar Singh Payal, Kapil Kumar, 2022, izvirni znanstveni članek Ključne besede: electro discharge machining, numerical simulation, residual stress, dielectric fluid, AISI A2 die steel, Gaussian distributed heat flux
Objavljeno v DiRROS: 22.06.2022; Ogledov: 532; Prenosov: 132
 Povezava na datoteko |
4. A review of computational fluid dynamics (CFD) simulations of mixing in the pharmaceutical industrySimon Babnik, Vivian Erklavec Zajec, Blaž Oblak, Blaž Likozar, Andrej Pohar, 2020, kratki znanstveni prispevek Ključne besede: computational fluid dynamics (CFD), mixing vessel, batch reactor, phar-maceutical industry, bioreactors, crystallization, particulate flow, process optimization, active pharmaceutical ingredient (API)
Objavljeno v DiRROS: 10.06.2020; Ogledov: 1875; Prenosov: 1210
Celotno besedilo (697,13 KB)
Gradivo ima več datotek! Več... |
