1. SOD1 variants in patients with amyotrophic lateral sclerosis in Central Eastern Europe : from genetic testing to SOD1 targeted therapyMagui Khazaal, Paula Stretavská, Magdalena Kuźma-Kozakiewicz, Krzysztof Nieporęcki, Adam Betík, Eva Vlčková, Monika Turčanová Koprušáková, Robert Petrovic, Hakan Cetin, Omar Keritam, Blaž Koritnik, 2026, izvirni znanstveni članek Povzetek: Background: Amyotrophic lateral sclerosis (ALS) is one of the most devastating fatal motor neuron diseases, characterized by progressive degeneration of motor neurons in the brain and spinal cord. A significant advance in ALS therapy was achieved with the recent European Medicines Agency approval of Tofersen, the first antisense oligonucleotide (ASO) specifically targeting SOD1 mRNA, a key genetic determinant of the disease. Yet, despite its clinical relevance, data on SOD1-ALS in Central Eastern Europe remain scarce. Methods: Here, we present a multicentric study across six countries—Austria, Czechia, Poland, Hungary, Slovakia, and Slovenia—representing approximately 16% of the European Union's population. We report all pathogenic, likely pathogenic, and uncertain SOD1 variants, along with the phenotypic features, including heritability, age, site of onset, and survival. We also assessed the availability of genetic testing, counseling, and access to Tofersen therapy across the region. Results: Out of 1200 patients with confirmed ALS, we identified 24 distinct pathogenic SOD1 variants in a total of 67 patients (median age at onset 47 [40–55] years), of whom 65.7% had familial ALS (fALS) and 34.3% had sporadic ALS (sALS). We characterized the associated phenotypes and reported that 42 patients are currently receiving Tofersen therapy. Conclusion: This study provides the first comprehensive overview of SOD1-ALS in Central Eastern Europe. Our findings underscore the importance of genetic testing and counseling, as well as equitable access to targeted therapies such as Tofersen to advance patient-specific care in this region.
Ključne besede: tofersen amyotrophic lateral sclerosis, Central Eastern Europe, motor neuron disease, SOD1, targeted therapy
Objavljeno v DiRROS: 28.08.2026; Ogledov: 105; Prenosov: 61
 Celotno besedilo (958,62 KB)
Gradivo ima več datotek! Več... |
2. The prediction of climate-driven habitat shifts of the rare and threatened moss Buxbaumia viridis in SloveniaDjordje P. Božović, Simona Strgulc Krajšek, Lado Kutnar, Janez Kermavnar, Anže Martin Pintar, Marko S. Sabovljević, 2026, izvirni znanstveni članek Povzetek: Buxbaumia viridis is a peculiar, deadwood-dependent cryptogamous moss characterized by reduced gametophytes and prominent sporophytes that develop directly from the protonema. The species is threatened in many European countries, listed in the EU Habitats Directive (Annex II), and protected under the Bern Convention. We applied ensemble species distribution modelling to project the potential distribution of B. viridis under multiple future climate scenarios and to assess its fate by analyzing the main bioclimatic and habitat factors influencing its survival in Slovenia, on the margin of the south-eastern Alps. The analysis was based on 54 occurrence records combined with bioclimatic, elevation and forest-type data using ensemble species distribution modeling. The models indicate that approximately 12% of Slovenia’s territory is potentially suitable for the species, primarily in mountainous regions, particularly in northern Slovenia. The highest probability of B. viridis occurrence was associated with very low minimum temperatures in the coldest month. Future projections predict a strong reduction in potentially suitable areas, ranging from 67.7 to 100%—depending on the reference period and emission scenario—indicating severe range contraction and a potential loss of suitable habitats and underscoring the urgent need for targeted conservation, monitoring and forest management strategies that preserve deadwood-rich forest stands with spruces and firs, to ensure long-term survival of B. viridis in Slovenia.
Ključne besede: bryophyte, climate change, forest, ENM, SDM, biomod2, Europe
Objavljeno v DiRROS: 30.07.2026; Ogledov: 228; Prenosov: 136
Celotno besedilo (527,23 KB)
Gradivo ima več datotek! Več... |
3. Practice and legislation of felling residue management to prevent forest pests in European forestsMaarten De Groot, Tine Hauptman, Kristjan Ait, Flavius Balacenoiu, Eckehard Brockerhoff, Luka Capuder, György Csóka, Mirza Dautbašić, Massimo Faccoli, Juraj Galko, Marija Kolšek, 2026, izvirni znanstveni članek Povzetek: In the last few decades, bark beetle outbreaks have increased in European forests, triggered by extreme weather events, such as drought and windstorms. A core element of integrated pest management to control outbreaks are salvage logging and sanitation felling, i.e., the timely removal or treatment of potential brood material and already infested trees after disturbance events. Associated with these management operations as well as with regular, planned thinning and cutting, felling residues, such as treetops, branches and stumps that remain in the forest provide potentially suitable breeding material for bark beetles and may trigger further outbreak events. Although felling residue management is part of regular forest management in most of Europe, no overview exists on its use throughout the continent. To fill this gap, we gathered forest health experts from 20 European countries and used a questionnaire to provide information on felling residue management in the context of forest protection in managed forests. Relevant legislation in these countries was reviewed for regulations concerning this topic. We found that most countries have felling residue management in their legislation and/or perform it in practice. In 12 of the 20 countries, felling residue management is being applied to manage bark beetles, particularly in areas that have experienced large-scale outbreaks in the last few decades. Felling residues are mainly managed in forests dominated by Norway spruce (Picea abies L. Karst) and pines (Pinus spp.) (in 19 and 17 of the countries, respectively). The most frequently used management methods on a European level were piling or mulching of felling residues. These methods were used in 14 and 16 of the countries, respectively. Besides bark beetle management, use of residues for bioenergy (4 countries) and biodiversity conservation (6 countries) was reported. The diversity of felling residue management practices across Europe may reflect differences in forest policies and climatic gradients that are affecting bark beetle outbreak risks. This overview presents the variety of felling residue management applied across 20 European countries, highlighting the reasons for and implications of its use, as well as further research needs.
Ključne besede: bark beetles, Europe, forest health, Pityogenes chalcographus, Ips typographus, logging residues
Objavljeno v DiRROS: 10.07.2026; Ogledov: 272; Prenosov: 183
Celotno besedilo (1,96 MB)
Gradivo ima več datotek! Več... |
4. |
5. |
6. Facing Foreigners in Urban Early Modern Europe : Legislation, Deliberation, Practice – Introduction to the Special Double IssueDarko Darovec, 2025, izvirni znanstveni članek Povzetek: This Introduction frames a special double issue of Acta Histriae comprising thirteen articles on foreigners in European towns (c. 1400–1800). Building on our project proposal’s analytic triad—law, deliberation, practice—it traces changing definitions of foreignness and the calibrated inclusion/exclusion of newcomers (status ladders, citizenship, guilds, markets, health regimes, gendered boundaries, marginality). To ensure comparability across diverse archives and regions, each contribution was synthesised through a transparent, prompt-guided LLM workflow, with human verification, yielding concise vignettes that foreground temporal change from medieval municipal grammars to early modern co-jurisdiction.
Ključne besede: early modern Europe, foreigners, foreigness, urban citizenship, law, municipal statutes
Objavljeno v DiRROS: 18.06.2026; Ogledov: 271; Prenosov: 199
Celotno besedilo (1,81 MB)
Gradivo ima več datotek! Več... |
7. Gradually European and Diminishingly Balkan : Communicating About Croatia in International Guidebooks During EU-AccessionZlatan Krajina, 2025, izvirni znanstveni članek Povzetek: This paper explores the cultural representation of Croatia in international guidebooks published during the process of the country’s EU-accession (2003–2013). Using a qualitative textual analysis of how the introductions’ narratives in the guidebooks depicted Croatia, this study recognises the dynamic interplay of aspects from European and Balkan identity. The country was constructed as a mobile destination, moving from the Balkans into “Europe”. Croatia’s developing tourist infrastructure was highlighted to describe the country as gradually becoming “European”. Simultaneously, there was a reduction in the explicit reference to the country’s Balkan identity, its peripheral location and transitional culture. I describe this representational strategy of ongoing and incomplete movement as “controlled proximity”.
Ključne besede: guidebook, cultural representation, communication, Croatia, Europe, the Balkans
Objavljeno v DiRROS: 18.06.2026; Ogledov: 276; Prenosov: 183
Celotno besedilo (2,15 MB)
Gradivo ima več datotek! Več... |
8. Sailing Through Time : A Comparative Study of Navigation Techniques in Zheng He’s Nautical Chart and European Portolan Charts in the Early Fifteenth CenturyBowen Chai, 2025, izvirni znanstveni članek Povzetek: 'Zheng He’s Nautical Chart’ and Portolan Charts were navigational tools used in China and Europe contemporaneously during the early fifteenth century and are visual representations of the navigation techniques practiced by Chinese and European mariners. However, there is a lack of comparative study of the navigation techniques presented in the charts, which often results in misunderstandings. This article bridges the gap by providing a detailed comparison of the navigation techniques through analysing the chart, historical records, and secondary research. It concludes that the similarities between Chinese and European navigation techniques far outweigh the differences. The finding indicates the diversity and unity inherent in human responses when confronted with comparable challenges.
Ključne besede: Zheng He’s Nautical Chart, portolan charts, navigation techniques, history of navigation techniques, China, Europe
Objavljeno v DiRROS: 15.06.2026; Ogledov: 231; Prenosov: 182
Celotno besedilo (2,19 MB)
Gradivo ima več datotek! Več... |
9. Time trends in preemptive kidney transplantation in Europe : an ERA registry studyAnneke Kramer, Rianne Boenink, Cynthia G Mercado Vergara, Samira Bell, Julia Kerschbaum, Olga L Rodríguez Arévalo, Auxiliadora Mazuecos, Aiko P J De Vries, Anna V Reisæter, Esther H S Wong, Miha Arnol, 2024, izvirni znanstveni članek Ključne besede: preemptive kidney, transplantation, Europe, kidney patients
Objavljeno v DiRROS: 15.06.2026; Ogledov: 338; Prenosov: 314
Celotno besedilo (1,18 MB)
Gradivo ima več datotek! Več... |
10. National cancer control programmes in Europe in 2024 : state of play and alignment with the European guide for quality NCCP'sMarjeta Kuhar, Tit Albreht, Polona Kastelic, Ana Molina-Barceló, Oscar García Sauret, Marjetka Jelenc, 2026, izvirni znanstveni članek Povzetek: Introduction
National Cancer Control Programmes (NCCPs) are essential policy documents guiding national cancer control planning. Their existence and quality are crucial for reducing cancer incidence, morbidity, and mortality, and for improving the quality of life of people with cancer and the population. The main aim of the present research, conducted within OriON Joint Action (2024–2025), was to explore and analyse the state of play, type, duration, evaluation, and quality of NCCPs across the European Union (EU) and selected countries, with a focus on the inclusion of key elements outlined in the European Guide for Quality NCCPs (Guide).
Methods
A structured survey was prepared, validated, and carried out in 2024 across 34 countries, including EU Member States, Iceland, Montenegro, Norway, Turkey, and Ukraine. The results were analysed and presented in tables and figures. Descriptive analysis using frequencies and percentages was conducted.
Results
The response rate was 100%. Of the 34 participating countries, 31 reported having an NCCP or equivalent cancer control document in 2024. Most countries had 1 comprehensive document, while 9 prepared multiple documents. The majority were defined as programmes and/or strategies, followed by plans and policies. In terms of quality, as recommended by the Guide, only 6 countries fully incorporated all suggested elements into their NCCPs.
Conclusions
Our findings indicate that most European countries recognise the significant challenge posed by cancer as a major public health problem and have developed NCCPs or equivalent cancer control documents. However, in terms of quality, there remains considerable room for improvement.
Ključne besede: cancer control, oriON joint, action, national cancer control programmes, oncology, cancer, Europe
Objavljeno v DiRROS: 06.06.2026; Ogledov: 262; Prenosov: 291
Celotno besedilo (577,64 KB)
Gradivo ima več datotek! Več... |
