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Povzetek: Background/Objectives: To assess overall and type-specific HPV vaccine effectiveness in central and eastern Europe (CEE), the age-stratified prevalence of cervical HPV infection was determined among Slovenian women aged 20 to 64 attending a cervical cancer screening program 14 years after implementation of a national HPV vaccination program, which was then compared with 2009-2010 pre-vaccination data using the same methodological approach. Methods: Cervical samples of 4419 women were tested in 2023-2025 using the clinically validated Alinity m HR HPV Assay, and individual HPV types were determined by the Allplex HPV HR Detection assay. Results were compared with 2009-2010 pre-vaccination data generated using the same assay on an age-range matched cohort of women. Results: The overall prevalence of the 14 Alinity-targeted HPV types was 10.0% in 2023-2025 versus 13.3% in 2009-2010 (p < 0.001). HPV16 prevalence declined from 3.5% to 1.5% (p < 0.001), and HPV18 prevalence from 1.1% to 0.5% (p = 0.005). In women aged 20 to 24 with 40% uptake of quadrivalent HPV vaccine, overall HPV prevalence dropped from 25.3% to 12.8% (p < 0.001). No single case of HPV16/HPV18 infection was detected among vaccinated women. Conclusions: The first large-scale, systematic, and methodologically consistent study of HPV vaccine effectiveness in CEE showed a substantial reduction in high-risk HPV prevalence after implementation of the national program, with the greatest decline among women aged 20 to 24, who harbored the highest HPV burden in the pre-vaccination era. These locally acquired data will considerably inform public health strategies on cervical cancer elimination in CEE.
Ključne besede: HPV, Slovenia, central ane eastern Europe, cervical cancer, prevalence, screening, vaccination
Objavljeno v DiRROS: 20.04.2026; Ogledov: 177; Prenosov: 118
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Povzetek: Newborn screening (NBS) is a well-established public health program that enables early detection and treatment of rare disorders in newborns, preventing severe complications or death. Despite its recognized importance, the scope and implementation of NBS programs vary across Southeastern (SE) and Central Europe. This study aimed to evaluate the current status of NBS in 16 countries of SE and Central Europe and assess progress since the previous survey in 2021. A structured questionnaire was distributed to national experts between April and December 2025, collecting data on program organization, coverage, diseases included, laboratory methods, confirmatory testing, consent practices, and future expansion plans. All countries reported universal screening for congenital hypothyroidism, except Kosovo, where a national NBS is in the process of being established. Expanded NBS using tandem mass spectrometry was available in Austria, Bulgaria, Croatia, Cyprus, Greece, Hungary, North Macedonia, Romania, and Slovenia. Spinal muscular atrophy screening became universal in Austria, Croatia, Hungary, Serbia, and Slovenia. Most countries reported plans for further expansion, with congenital adrenal hyperplasia, severe combined immunodeficiency, spinal muscular atrophy, and cystic fibrosis being the most frequently targeted conditions. Although notable infrastructural progress has been achieved, financial constraints, lack of staff, and organizational barriers remain key challenges. The study’s assessment of program effectiveness was further limited by the absence of region-wide systems for capturing end-to-end performance indicators, such as the age of the infant at treatment initiation or missed cases. Regional collaboration and adoption of best practices are therefore vital to ensure equitable access and continuous advancement of NBS programs.
Ključne besede: newborn screening, NBS, Southeastern Europe, Central Europe, neonatal screening, expanded NBS program
Objavljeno v DiRROS: 06.03.2026; Ogledov: 356; Prenosov: 242
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Povzetek: In Central Europe, borders are not solid barriers but are rather fluid. Central Europe is a deeply connected cultural space of intensive exchange (M. Csáky) in which artistic production is shaped by densely intertwined mutual contacts and influences between individual countries and regions. This is particularly visible in the activities of large architectural, painting and sculptural workshops in the 18th century, which had a wide network of collaborators throughout the area. A key role in the rapid and far-reaching transfer of artistic solutions was played by the commissioners of artworks, both ecclesiastical and secular, strongly connected by a dense network of contacts that did not stop at (today’s national) borders. This paper studies the example of the activities of the architectural workshop of Joseph Hueber from Graz (1715–1787) in historical Styria, present-day Austria, and Lower Styria (present-day Slovenia) and northwestern Croatia to explore the method and scope of the workshop’s work, as well as the reconstruction of contacts between commissioners from the ranks of the Styrian, Hungarian and Croatian nobility.
Ključne besede: Central Europe, Styria, Slovenia, Croatia, Baroque architecture, borders, building workshops, Joseph Hueber, art patronage, the nobility
Objavljeno v DiRROS: 21.01.2026; Ogledov: 487; Prenosov: 297
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Povzetek: This introductory article reflects heritage-making processes in the Central and Eastern European (CEE) context. It links discussions of the ZRC SAZU multidisciplinary research program on heritage with case studies presented at the conference Heritage on the Margins? (November 2023, Ljubljana). The focus of the article is heritage formation and the performative influence of heritage in minority, remote, linguistic, industrial, (post)imperial, (post)socialist and otherwise marginalized settings.
Ključne besede: heritage, critical heritage studies, marginality-centrality, Central and Eastern Europe
Objavljeno v DiRROS: 19.01.2026; Ogledov: 520; Prenosov: 282
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Povzetek: Background. Immunotherapy with immune checkpoint inhibitors (ICIs) recently became the standard treatment for patients with advanced non-small cell lung cancer (NSCLC). Here, we present the first results of a real-world observational study on the effectiveness of ICI monotherapy in patients with advanced NSCLC treated at a single academic center in a Central and Eastern European (CEE) country. Materials and methods. Overall, 66 consecutive patients with advanced NSCLC treated with ICIs in everyday clinical practice, either with first-line pembrolizumab (26 patients) or second-line atezolizumab, nivolumab, or pembrolizumab (40 patients), from August 2015 to November 2018, were included. All data were retrieved from a hospital lung cancer registry, in which the data is collected prospectively. Results. Included patients had a median age of 64 years, most were male (55%), 6% were in performance status >/=2, and 18% had controlled central nervous system metastases at baseline. In first-line, the median progression-free survival (mPFS) was 9.3 months, while the median overall survival (mOS) was not reached. The 1-year overall survival (OS) was 62%. In second-line, the mPFS and mOS were 3.5 months and 9.9 months, respectively, with a 1-year OS of 35%. In the overall population, adverse events of any grade were recorded in 79% of patients and of severe grade (3-4) in 12% of patients. Conclusion. The first real-world outcomes of NSCLC immunotherapy from a CEE country suggest comparable effectiveness to those observed in clinical trials and other real-world series, mainly coming from North America and Western European countries. Further data to inform on the real-world effectiveness of immunotherapy worldwide are needed.
Ključne besede: non-small cell lung carcinoma, immunotherapy, advanced non-small cell lung cancer, real-world data, Central Europe, Europe, Eastern Europe
Objavljeno v DiRROS: 12.10.2021; Ogledov: 2291; Prenosov: 990
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