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2. Allergic rhinitis and its impact on asthma (ARIA) phase 4 (2018) : change management in allergic rhinitis and asthma multimorbidity using mobile technologyFlore Amat, Ioana Agache, Peter W. Hellings, Jean Bousquet, Mihaela Zidarn, Anna Bedbrook, Eric Bateman, Claus Bachert, Josep M. Antò i Boquè, Ignacio J. Ansotegui, Isabella Annesi-Maesano, 2019 Povzetek: Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.
Ključne besede: asthma -- guideline, rhinitis, allergic -- guideline, change management, multimorbidity, critical pathways, mobile applications
DiRROS - Objavljeno: 22.10.2020; Ogledov: 481; Prenosov: 79 |
3. Glycosylation enhances allergenic activity of major bee venom allergen Api m 1 by adding IgE epitopesIrene Mittermann, Rudolf Valenta, Peter Korošec, Mihaela Zidarn, Urška Bidovec, Pia Gattinger, 2020 Ključne besede: insect venom allergy, Api m 1, allergen, glycosylation, allergenic activity
DiRROS - Objavljeno: 26.10.2020; Ogledov: 506; Prenosov: 255
 Celotno besedilo (433,49 KB) |
4. Towards personalization of asthma treatment according to trigger factorsKatarzyna Niespodziana, Jean Bousquet, Elena Borzova, Angelika Berger, Evgenyi Beltiukov, Mohamed-Ridha Barbouche, Tatiana Baranovskaya, Natalia Astafyeva, Thomas Schlederer, Petra Pazderova, Kristina Borochova, Mihaela Zidarn, Rudolf Valenta, 2020 Povzetek: Asthma is a severe and chronic disabling disease affecting more than 300 million people world-wide. While in the past few drugs for treatment of asthma were available, new treatment options are currently emerging which appear to be highly effective in certain subgroups of patients. Accordingly there is a need for biomarkers which allow selection of patients for refined and personalized treatment strategies. Recently, serological chip tests based on micro-arrayed allergen molecules and peptides derived from the most common rhinovirus strains have been developed which may discriminate two of the most common forms of asthma, i.e., allergen- and virus-triggered asthma. In this perspective we argue that classification of asthma patients according to these common trigger factors may open new possibilities for personalized management of asthma.
Ključne besede: allergy and immunology, asthma, signs and symptoms, respiratory, rhinovirus, allergens, microarray analysis, precision medicine, wheeze
DiRROS - Objavljeno: 31.07.2020; Ogledov: 795; Prenosov: 390
Celotno besedilo (292,51 KB) |
5. Is diet partly responsible for differences in COVID-19 death rates between and within countries? : protocol for a systematic reviewMihaela Zidarn, Jure Urbančič, Tanja Soklič, Davor Plavec, Bojan Madjar, Klemen Jenko, Samo Kreft, Maja Jošt, Peter Kopač, Anja Koren, Mitja Košnik, Tari Haahtela, Karmen Kramer Vrščaj, Giorgio Walter Canonica, Hubert Blain, Cezmi A. Akdis, Aram Anto, Tari Haahtela, Wienczyslawa Czarlewski, Guido Laccarino, Josep M. Antò i Boquè, Jean Bousquet, 2020 Povzetek: Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit.
Ključne besede: coronavirus, diet, angiotensin-converting enzyme, antioxidant, food
DiRROS - Objavljeno: 09.09.2020; Ogledov: 681; Prenosov: 336
Celotno besedilo (1,12 MB) |
6. ARIA digital anamorphosis : digital transformation of health and care in airway diseases from research to practiceJean Bousquet, Josep M. Antò i Boquè, Claus Bachert, Tari Haahtela, Torsten Zuberbier, Wienczyslawa Czarlewski, Anna Bedbrook, Sinthia Bosnic-Anticevitch, Giorgio Walter Canonica, Victoria Cardona, Mihaela Zidarn, 2020 Povzetek: Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
Ključne besede: digital transformation of healthcare, e-health, ARIA guidelines, MASK
DiRROS - Objavljeno: 29.07.2020; Ogledov: 788; Prenosov: 0 |
7. Cabbage and fermented vegetables : from death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19Jean Bousquet, Josep M. Antò i Boquè, Wienczyslawa Czarlewski, Tari Haahtela, Susana C. Fonseca, Guido Laccarino, Hubert Blain, Alain Vidal, Aziz Sheikh, Cezmi A. Akdis, Torsten Zuberbier, Samo Kreft, Klemen Jenko, Maja Jošt, Peter Kopač, Mitja Košnik, Karmen Kramer Vrščaj, Bojan Madjar, Davor Plavec, Tanja Soklič, Jure Urbančič, Mihaela Zidarn, 2020 Povzetek: Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage were associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin converting enzyme 2 (ACE2). As a result of SARS-Cov-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT1R) axis associated with oxidative stress. This leads to insulin resistanceas well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block the AT1R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are given: Kimchi in Korea, westernized foods and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects helpful in mitigating COVID-19 severity.
Ključne besede: COVID-19, diet, sulforaphane, Lactobacillus, Angiotensin converting enzyme 2, kimchi, cabbage, fermented vegetable
DiRROS - Objavljeno: 07.10.2020; Ogledov: 569; Prenosov: 117 |
8. ARIA-EAACI statement on asthma and COVID-19 (June 2, 2020)Jean Bousquet, Marek Jutel, Cezmi A. Akdis, Ludger Klimek, Oliver Pfaar, Kari Nadeau, Thomas Eiwegger, Anna Bedbrook, Ignacio J. Ansotegui, Josep M. Antò i Boquè, Mihaela Zidarn, 2020 Ključne besede: asthma, covid-19, SARS-CoV-2
DiRROS - Objavljeno: 07.10.2020; Ogledov: 711; Prenosov: 439
Celotno besedilo (874,62 KB) |
9. ARIA pharmacy 2018 "Allergic rhinitis care pathways for community pharmacy"Sinthia Bosnic-Anticevitch, Elisio Costa, Enrica Menditto, Olga Lourenço, Ettore Novellino, Slawomir Bialek, Vitalis Briedis, Roland Buonaiuto, Henry Chrystyn, Biljana Cvetkovski, Mihaela Zidarn, 2019 Povzetek: Pharmacists are trusted health professionals. Many patients use over-the-counter (OTC) medications and are seen by pharmacists who are the initial point of contact of allergic rhinitis management in most countries. The role of pharmacists in integrated care pathways (ICPs) for allergic diseases is important. This paper builds on existing studies and provides tools intended to help pharmacists provide optimal advice/interventions/strategies to patients with rhinitis. The ARIA-pharmacy ICP includes a diagnostic questionnaire specifically focusing attention on key symptoms and markers of the disease, a systematic Diagnosis Guide (including differential diagnoses) and a simple flowchart with proposed treatment for rhinitis and asthma multimorbidity. Key prompts for referral within the ICP are included. The use of technology is critical to enhance the management of AR. However, the ARIA-pharmacy ICP should be adapted to local health care environments/situations as regional (national) differences exist in pharmacy care.
Ključne besede: asthma -- guideline, allergic rhinitis -- Guideline, pharmacists, drug therapy, nonprescription drugs, critical pathways, allergic diseases
DiRROS - Objavljeno: 09.10.2020; Ogledov: 466; Prenosov: 119 |
10. Quantitative, absolute count-based T cell analysis of CD69 upregulation as a new methodology for in vitro diagnosis of delayed-type nickel hypersensitivityAna Koren, Mira Šilar, Helena Rupnik, Mihaela Zidarn, Peter Korošec, 2019 Povzetek: Background: T cells play a major role in delayed-type hypersensitivity reactions. Their reactivity can be assessed by measuring the upregulation of the activation marker CD69, followed by proliferation and cytokine production. The aim of our study was to develop a novel, whole blood-based, quantitative, absolute count activation index (AI) analysis of CD69 upregulation on different subsets of T cells in nickel hypersensitive patients and compare it with the previously reported approaches. Methods: Ten patients with nickel allergy and nine healthy controls were included. CD69 expression of CD3+, CD3+CD4+ and CD3+CD8+ T cells in heparinized blood was determined with flow cytometry after incubation with nickel sulfate for 48 h. The absolute cell count of CD69+ cells was determined with microbeads. The production of the cytokines IL-2, IL-5, IL-13, and IFN-[gamma] was determined after nickel sulfate stimulation of PBMNCs for 48 h. Results: We showed that the most sensitive methodology is the absolute AI, which was calculated as the ratio between the absolute count of CD69-positive T cells stimulated with nickel and the absolute count of CD69-positive T cells in non-stimulated blood. This novel quantitative approach was more discriminative than the previously reported approaches in which T cell CD69 percentage AI and cytokine production are measured. Conclusions: Our results demonstrated that measuring the absolute CD69 AI is an accurate new approach to quantify antigen-specific T cells in the blood of patients with hypersensitivity reactions to nickel. This approach may be useful for better in vitro assessment of patients with delayed-type hypersensitivity reactions.
Ključne besede: allergy and immunology, delayed hypresensitivity, nickel, blood, CD antigenes, CD69
DiRROS - Objavljeno: 18.11.2020; Ogledov: 448; Prenosov: 87 |
