11. Is there any progress in routine management of lung cancer patients? A comparative analysis of an institution in 1996 and 2006Lučka Debevec, Tina Jerič, Viljem Kovač, Marko Bitenc, Mihael Sok, 2009, izvirni znanstveni članek Povzetek: Background. The aim of the study was to establish eventual progress in routine management of lung cancer patients over a ten-year period at University Clinic for Respiratory and Allergic Diseases Golnik, Slovenia, comparing the results of analysis of 345 patients, diagnosed in 1996 (with analysis performed in 2002), and 405 patients, diagnosed in 2006 (with analysis performed in 2008).Patients and methods. The patients of both analysed groups were of comparable age and number of patients in stage I and II, but there were relatively more females, patients with better performance status, more precise clinical staging and tumour histology in the 2006 group. The parameters used for assessing the progress of management were as follows: time period from admittance to diagnosis and to surgery; precision of staging; accordance of clinical and pathological staging in resected patients; percentage of exploratory thoracotomy; and use of new treatment modalities. The proportion of patients in selected/actual primary treatment modality and survival rate could also be used for assessing the progress. Results. Althoughunessential longer time from admittance to microscopic confirmed diagnosis increased from a mean 7.4 to 8.6 days in 2006 progress was established by the following: more precise clinical staging (stage I and II also A and B stage, TNM staging also in small-cell lung cancer patients); improved accordance with clinical and pathological staging in resected patients (46% against 58%); decreased percentage of exploratory thoracotomy (13% against 4%); increased use of multimodality therapy as primary treatment modality (radiotherapy/chemotherapy, neoadjuvant chemotherapy); newly performed radio frequency tumour ablation. The proportion in selected/actual surgery increased from 76% to 93% and median survival rate of all patients from 6.2 to 10.6 months. (Abstract truncated at 2000 characters)
Objavljeno v DiRROS: 08.03.2024; Ogledov: 101; Prenosov: 29
 Celotno besedilo (80,75 KB) |
12. Difference between using tabulated and exact values of thermal properties of materials in numerical simulations of heat transfer through a high-performance windowMiha Jukić, Sabina Jordan, 2019, objavljeni znanstveni prispevek na konferenci Povzetek: The thermal properties of materials, primarily the thermal conductivity, are an essential input for numerical modelling of heat transfer in buildings and building components. When determining them according to relevant European standards, it is not uncommon to encounter materials for which the exact values are not appropriately specified and the tabulated values in standards are overly conservative. In such situations, the thermal conductivity of the material can be determined by measurement. However, this approach may prove inconvenient and too expensive, especially if the material in question turns out to have little influence on the overall thermal performance of the product. It is, therefore, of great interest to know how the thermal performance is affected by choosing either the accurate (measured) or the conservative (tabulated) value of the thermal conductivity. In this work, the two approaches are compared in a practical example – a high-performance window, Jelovica Jelofuture – using numerical simulations. Our study shows that modifying the thermal properties of individual materials generally leaves the thermal transmittances of the frame (Uf) and the window (UW) almost unaffected. If all of the materials considered are modified simultaneously, Uf changes by 1–2% while the change in UW remains below 1%. However, due to their small values, the calculated changes of Uf and UW may be significantly affected (further increased or reduced) by the rounding of the results according to the relevant standards. In contrast, using the tabulated value of linear thermal transmittance (Ψg) of the junction with the glazing leads to an overestimation of UW by up to 15%.
Ključne besede: thermal transmittance, numerical simulation, conductivity, tabulated and exact values, practical example
Objavljeno v DiRROS: 08.03.2024; Ogledov: 91; Prenosov: 47
Celotno besedilo (282,29 KB)
Gradivo ima več datotek! Več... |
13. |
14. |
15. |
16. Preoperative concomitant chemoradiotherapy in esophageal cancerBoštjan Šeruga, Mihael Sok, Janez Eržen, Jože Jerman, Boris Jančar, Branko Zakotnik, 2006, izvirni znanstveni članek Povzetek: Background. Currently primary treatment options for esophageal cancer are surgery only or concomitant chemoradiotherapy (CRT) and the long-term survivalof patients with locally advanced disease is rare. Preoperative concomitant CRT seems to be beneficial, mostly in patients who achieve a complete pathologic response (pCR) after CRT. In this retrospective analysis the efficiency and toxicity of preoperative CRT in patients with locally advanced esophageal cancer was analysed as well as the influence of pCR on thesuraival. Patients and metkods From 1996 to 2002 41 patients with locoregionally confined esophageal cancerwere treated with cisplatin 75 mgžm2 and 5-FU 1000 mgžm2 as 4 day contonuous infusion starting on days 1. and 22. with concorrtitant radiotherapy 4500 cGy, 200-300 cGyžday. Esophagectomy followed 4-5 weeks after radiotherapy. After the surgery patients were followed-up regularly at 3-6 months intervals. Results. The pCR was achieved in 26.8% of patients. The overall median survival time was 18 months for all patients, 21.2 months for patients who achieved pCR and 16 months in those with residual disease (p= 0,79). Postoperative mortality rate was 22%. The median dose intensity for cisplatin was 92% and for 5-FU 71.5 of the planned dose. Disease recurred most often locoregionally (31.7%) and the overall recurrence rate was 43.9. Conclusion. Modern radiation techniques and the adequate dose intensity could further improve the locoregional control. The selection of patients without comorbid conditions and without already present distant metastases is essential for this combined treatment approach.
Objavljeno v DiRROS: 15.02.2024; Ogledov: 124; Prenosov: 35
Celotno besedilo (123,83 KB) |
17. Surgical treatment of malignant pleural mesotheliomaJanez Eržen, Stanko Vidmar, Mihael Sok, Andrej Debeljak, Peter Kecelj, Viljem Kovač, Marjeta Stanovnik, Tomaž Rott, Izidor Kern, 2005, izvirni znanstveni članek Povzetek: Background. The aim of the study was to identify perioperative morbidity and mortality, the category and mode of adjuvant treatment, local recurrence and survival in patients treated by extrapleural pneumonectony (EPP) for malignantpleural mesothelioma (NLPM). Methods. From 2000 to 2003, 18 patients with MPM were referred to the Department of Thoracic Surgery in Ljubljana, and17 of them were operated on. Two patients underwent explorative thoracotomy, and 15 patients were evaluated. Five female and nine male patients (aged 52-68 years) were treated by EPP and one male patient by pleurectomy. Eight patients received both adjuvant chemotherapy (ChT) and radiotherapy (RT), with cisplatin 100 mg/m2 + mitomycin C 6-10 mg/m2 gemcitabine 1000 mg/m2 and external beam radiation with 24 Gy - 58 Gy respectively, three patients received no adjuvant therapy, three patients weretreated by adjuvant ChT, two of them were given cisplatin 100 mg/m2 + mitomycin C 6-10 mg/m2, and one patient cisplatin 100 mg/m2 on the first day and gemcitabine 250 mg/rn2 in prolonged 6 hours infusion on the first and on the eighth day. One patient was treated only by adjuvant RT. Results. There were no perioperative deaths and the postoperative morbidity was 42%. Of the 15 evaluable patients, and in the median follow up of 40 months (28-64), we noticed nine (60.0%) recurrences, seven local and two abdominal. Eight (53.3%)patients died, all because of the local progress of disease. (Abstract truncated at 2000 characters)
Objavljeno v DiRROS: 14.02.2024; Ogledov: 149; Prenosov: 37
Celotno besedilo (82,10 KB) |
18. Metal artefacts and remains of armour from Kozlov Rob castle : metallurgical analyses as a tool for identification and interpretation of fragmentary archaeological findsJakob Kraner, Tomaž Lazar, Miha Mlinar, Jaka Burja, 2023, izvirni znanstveni članek Ključne besede: archaeology, castle, Kozlov Rob, Slovenia, armour, helmet, metallography
Objavljeno v DiRROS: 07.02.2024; Ogledov: 152; Prenosov: 76
Celotno besedilo (3,92 MB)
Gradivo ima več datotek! Več... |
19. Oligomeric fragments distribution, structure and functionalities upon ruthenium-catalyzed technical lignin depolymerizationTina Ročnik, Erika Bartolomei, Anthony Dufour, Sébastien Leclerc, Philippe Arnoux, Blaž Likozar, Edita Jasiukaityte, Miha Grilc, Yann Le-Brech, 2024, izvirni znanstveni članek Objavljeno v DiRROS: 07.02.2024; Ogledov: 158; Prenosov: 76
Celotno besedilo (4,79 MB)
Gradivo ima več datotek! Več... |
20. Cathepsin L in human meningiomasMiha Trinkaus, Andrej Vranič, Vinko V. Dolenc, Tamara Lah Turnšek, 2003, izvirni znanstveni članek Ključne besede: meningioma-pathology, cathepsin L, reverse transcriptase, polymerase chain reaction, neoplasm invasiveness
Objavljeno v DiRROS: 06.02.2024; Ogledov: 154; Prenosov: 39
Celotno besedilo (230,61 KB) |
