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Iskalni niz: "avtor" (Lea Knez) .

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Immunotherapy for metastatic non-small cell lung cancer : real-world data from an academic Central and Eastern European center
Marija Ivanović, Lea Knez, Ana Herzog, Mile Kovačević, Tanja Čufer, 2021, izvirni znanstveni članek

Povzetek: Background. Immunotherapy with immune checkpoint inhibitors (ICIs) recently became the standard treatment for patients with advanced non-small cell lung cancer (NSCLC). Here, we present the first results of a real-world observational study on the effectiveness of ICI monotherapy in patients with advanced NSCLC treated at a single academic center in a Central and Eastern European (CEE) country. Materials and methods. Overall, 66 consecutive patients with advanced NSCLC treated with ICIs in everyday clinical practice, either with first-line pembrolizumab (26 patients) or second-line atezolizumab, nivolumab, or pembrolizumab (40 patients), from August 2015 to November 2018, were included. All data were retrieved from a hospital lung cancer registry, in which the data is collected prospectively. Results. Included patients had a median age of 64 years, most were male (55%), 6% were in performance status >/=2, and 18% had controlled central nervous system metastases at baseline. In first-line, the median progression-free survival (mPFS) was 9.3 months, while the median overall survival (mOS) was not reached. The 1-year overall survival (OS) was 62%. In second-line, the mPFS and mOS were 3.5 months and 9.9 months, respectively, with a 1-year OS of 35%. In the overall population, adverse events of any grade were recorded in 79% of patients and of severe grade (3-4) in 12% of patients. Conclusion. The first real-world outcomes of NSCLC immunotherapy from a CEE country suggest comparable effectiveness to those observed in clinical trials and other real-world series, mainly coming from North America and Western European countries. Further data to inform on the real-world effectiveness of immunotherapy worldwide are needed.
Ključne besede: non-small cell lung carcinoma, immunotherapy, advanced non-small cell lung cancer, real-world data, Central Europe, Europe, Eastern Europe
Objavljeno v DiRROS: 12.10.2021; Ogledov: 784; Prenosov: 236
URL Povezava na datoteko

Tarčna terapija in imunoterapija pljučnega raka
Tanja Čufer, Lea Knez, 2015, objavljeni strokovni prispevek na konferenci (vabljeno predavanje)

Ključne besede: pljučni rak, tarčna terapija, imunoterapija
Objavljeno v DiRROS: 08.05.2020; Ogledov: 1336; Prenosov: 367
.pdf Celotno besedilo (279,29 KB)

Interakcije tarčnih zdravil z drugimi zdravili, hrano in prehranskimi dopolnili
Lea Knez, 2015, objavljeni strokovni prispevek na konferenci

Ključne besede: tarčna zdravila, interakcija med zdravili, inhibitorji, induktorji, onkologija
Objavljeno v DiRROS: 22.01.2020; Ogledov: 1588; Prenosov: 449
.pdf Celotno besedilo (665,24 KB)

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