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1.
A small bacteriophage protein determines the hierarchy over co-residential jumbo phage in Bacillus thuringiensis serovar israelensis
Anja Pavlin, Anže Lovše, Gregor Bajc, Jan Otoničar, Amela Kujović, Živa Lengar, Ion Gutiérrez-Aguirre, Rok Kostanjšek, Janez Konc, Nadine Fornelos, Matej Butala, 2022, izvirni znanstveni članek

Povzetek: Bacillus thuringiensis serovar israelensis is the most widely used biopesticide against insects, including vectors of animal and human diseases. Among several extrachromosomal elements, this endospore-forming entomopathogen harbors two bacteriophages: a linear DNA replicon named GIL01 that does not integrate into the chromosome during lysogeny and a circular-jumbo prophage known as pBtic235. Here, we show that GIL01 hinders the induction of cohabiting prophage pBtic235. The GIL01-encoded small protein, gp7, which interacts with the host LexA repressor, is a global transcription regulator and represses the induction of pBtic235 after DNA damage to presumably allow GIL01 to multiply first. In a complex with host LexA in stressed cells, gp7 down-regulates the expression of more than 250 host and pBtic235 genes, many of which are involved in the cellular functions of genome maintenance, cell-wall transport, and membrane and protein stability. We show that gp7 homologs that are found exclusively in bacteriophages act in a similar fashion to enhance LexA’s binding to DNA, while likely also affecting host gene expression. Our results provide evidence that GIL01 influences both its host and its co-resident bacteriophage.
Objavljeno v DiRROS: 18.07.2024; Ogledov: 194; Prenosov: 173
.pdf Celotno besedilo (3,46 MB)
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2.
An exact algorithm to find a maximum weight clique in a weighted undirected graph
Kati Rozman, An Ghysels, Dušanka Janežič, Janez Konc, 2024, izvirni znanstveni članek

Objavljeno v DiRROS: 30.04.2024; Ogledov: 366; Prenosov: 198
.pdf Celotno besedilo (1,43 MB)
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Loop grafting between similar local environments for Fc-silent antibodies
Samo Lešnik, Milan Hodošček, Barbara Podobnik, Janez Konc, 2020, izvirni znanstveni članek

Objavljeno v DiRROS: 25.11.2020; Ogledov: 1387; Prenosov: 863
.pdf Celotno besedilo (5,77 MB)
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