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Povzetek: Introduction: Regular physical activity during pregnancy is associated with several maternal and neonatal health benefits. However, most studies focus on specific forms of exercise in low-risk populations, limiting generalizability. Objective: To investigate associations between regular physical activity during singleton pregnancy and perinatal outcomes using a national perinatal registry. Methods: A population-based cohort study was conducted using data from the Slovenian National Perinatal Information System (2013–2022), which included 190,331 singleton pregnancies. Regular physical activity was defined as any form of physical activity at least twice weekly throughout pregnancy. The outcomes analyzed included preterm birth (<37 and <32 weeks), preeclampsia, gestational hypertension, gestational diabetes mellitus (GDM), pelvic girdle pain, small-for-gestational-age (SGA) and large-for-gestational-age (LGA) neonates, cesarean delivery, urinary incontinence postpartum, and Apgar scores < 7 at 5 minutes. Multivariate logistic regression adjusted for parity, maternal age, BMI, prepregnancy hypertension and diabetes, and gestational weight gain. Results: Regular physical activity during pregnancy was reported by 69 % of the women. It was significantly associated with reduced odds of preterm birth (<37 weeks, aOR 0.658; <32 weeks, aOR 0.393), preeclampsia (aOR 0.719), gestational hypertension (aOR 0.708), pelvic girdle pain (aOR 0.808), SGA (aOR 0.903), LGA (aOR 0.902) and low Apgar scores (aOR 0.638). Physically active women with GDM were less likely to require insulin (aOR 0.768). No significant associations were found with cesarean delivery or urinary incontinence. Conclusion: Regular physical activity during pregnancy, regardless of specific type, was associated with improved perinatal outcomes without safety concerns. These findings highlight the potential benefits of encouraging physical activity during pregnancy in diverse populations.
Ključne besede: pregnancy, physical activity, perinatal outcome
Objavljeno v DiRROS: 27.02.2026; Ogledov: 127; Prenosov: 44
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Povzetek: Introduction: The purpose of this national research was to compare birth, maternal and newborn outcomes in the midwife led unit and the obstetric unit to ascertain whether a midwife led unit reduced medicalisation of childbirth. Methods: A prospective observational case-control study was carried out in Ljubljana Maternity Hospital in the period May - August 2013. The sample comprised 497 labouring women; 154 who attended the midwife led and 343 who attended in the obstetric unit, both matching the same inclusion criteria: low risk primiparous; singleton term pregnancies, normal foetal heart beat, cephalic presentation; spontaneous onset of labour. The primary outcome was the caesarean section rate. Chi-square test was used to compare medical interventions and birth outcomes. Results: Women in the midwife led unit had statistically significant higher spontaneous vaginal births (p < 0.001), less augmentation with oxytocin (p < 0.001), less use of analgesia (p < 0.001), less operative vaginal deliveries (p < 0.001) and less caesarean sections (p < 0.001), lower rates of episiotomy (p < 0.001) and more exclusively breastfed (p = 0.002). Discussion and conclusion: These significant findings showed that in the midwife led unit fewer medical interventions were used. For generalisation of the findings more similar studies in Slovenia are needed.
Ključne besede: low risk, labour, medical interventions, perinatal outcomes
Objavljeno v DiRROS: 28.01.2026; Ogledov: 190; Prenosov: 65
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Povzetek: Objective Cerebral palsy (CP) is a group of neurological disorders with profound implications for children’s development. The identification of perinatal risk factors for CP may lead to improved preventive and therapeutic strategies. This study aimed to identify the early predictors of CP using machine learning (ML). Design This is a retrospective case–control study, using data from the two population-based databases, the Slovenian National Perinatal Information System and the Slovenian Registry of Cerebral Palsy. Multiple ML algorithms were evaluated to identify the best model for predicting CP. Setting This is a population-based study of CP and control subjects born into one of Slovenia’s 14 maternity wards. Participants A total of 382CP cases, born between 2002 and 2017, were identified. Controls were selected at a control-to-case ratio of 3:1, with matched gestational age and birth multiplicity. CP cases with congenital anomalies (n=44) were excluded from the analysis. A total of 338CP cases and 1014 controls were included in the study. Exposure 135 variables relating to perinatal and maternal factors. Main outcome measures Receiver operating characteristic (ROC), sensitivity and specificity. Results The stochastic gradient boosting ML model (271 cases and 812 controls) demonstrated the highest mean ROC value of 0.81 (mean sensitivity=0.46 and mean specificity=0.95). Using this model with the validation dataset (67 cases and 202 controls) resulted in an area under the ROC curve of 0.77 (mean sensitivity=0.27 and mean specificity=0.94). Conclusions Our final ML model using early perinatal factors could not reliably predict CP in our cohort. Future studies should evaluate models with additional factors, such as genetic and neuroimaging data
Ključne besede: early predictors, cerebral palsy
Objavljeno v DiRROS: 10.12.2025; Ogledov: 358; Prenosov: 150
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Povzetek: Background/Objectives: The optimal anesthetic technique for category 2 and 3 cesarean deliveries remains debated, with concerns about impacts on decision-to-delivery interval (DDI) and perinatal outcomes. This study examined the influence of epidural, spinal, and general anesthesia on DDI, surgical and postoperative complications, and neonatal outcomes. Methods: This prospective cohort study at a tertiary perinatology center enrolled parturient women undergoing category 2 and 3 cesarean deliveries. Three DDI phases were assessed for each anesthetic modality: transfer time (decision for cesarean section to admission in the operation room), anesthetic time (admission to incision), and delivery time (incision to delivery of the neonate). The surgical procedure time (incision to closure), neonatal (5 min Apgar score, umbilical artery pH/base excess, neonatal intensive care unit (NICU) admission) and maternal (blood loss, surgical and postoperative complications) outcomes were also analyzed for each group. Results: There were 215 women (122 category 2 and 93 category 3) included. The use of epidural and general anesthesia was associated with significantly shortened DDI compared to spinal anesthesia (p < 0.001). This difference was due prolonged transfer (p < 0.05) and anesthetic times (p < 0.001), respectively. No cases of umbilical artery pH below 7 were observed in any group. No significant differences were observed in the incidence of umbilical artery pH between 7 and 7.10 or in base excess below -12 nmol/L (p = 0.416 and p = 0.865, respectively). NICU admission was higher with both general and spinal anesthesia (p = 0.021), but mainly due to a higher proportion of preterm births, both before the 32nd week (p = 0.033) and between the 32nd and 37th week of pregnancy (p < 0.001). General anesthesia was associated with higher maternal blood loss (p = 0.026) and a higher rate of postoperative complications (p = 0.006). Conclusions: In category 2 and 3 cesarean deliveries, general and epidural anesthesia were associated with shorter DDI compared to spinal anesthesia with no differences in neonatal outcomes. General anesthesia was associated with a higher risk of maternal complications compared to neuraxial anesthetic techniques.
Ključne besede: cesarean delivery anesthesia, decision-to-delivery interval, epidural anesthesia, general anesthesia, maternal outcomes, neonatal outcomes, spinal anesthesia
Objavljeno v DiRROS: 01.12.2025; Ogledov: 396; Prenosov: 150
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Povzetek: The human sperm head vacuoles and their role in male infertility are still poorly understood. The aim of this study was to identify the clinical and ultrastructural features of human sperm head vacuoles in men included in the in vitro fertilization programme: men with normal (normozoospermia) and impaired sperm morphology (teratozoospermia). The sperm samples were observed under 6000-time magnification using motile sperm organelle morphology examination (MSOME). The proportion of sperm with head vacuoles was evaluated and related to the outcome of in vitro fertilization. The sperm of men with impaired sperm morphology was characterized by a higher proportion of sperm head vacuoles. The sperm head vacuoles were related to impaired semen quality (sperm concentration, motility, and morphology) but were not influenced by male factors (semen volume, height, age, weight, or body mass index). Moreover, sperm head vacuoles were related to impaired fertilization rate merely after classical in vitro fertilization (IVF), while there was no relation to pregnancy. In a subgroup of men, the sperm was fixed and observed by transmission electron microscopy (TEM). The ultrastructural study revealed that sperm head vacuoles are large nuclear indentations of various sizes and positions, packed with membranous material organized in membrane whorls (MW).
Ključne besede: human sperm head vacuoles, male infertility
Objavljeno v DiRROS: 04.03.2025; Ogledov: 696; Prenosov: 775
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