1. Treatment of vulvar cancer recurrences with electrochemotherapy : a detailed analysis of possible causes for unsuccessful treatmentGregor Vivod, Tanja Jesenko, Gorana Gašljević, Nina Kovačević, Maša Omerzel, Gregor Serša, Sebastjan Merlo, Maja Čemažar, 2023, izvirni znanstveni članek Povzetek: Background. Electrochemotherapy has good local effectiveness in the treatment of vulvar cancer. Most studies have reported the safety and effectiveness of electrochemotherapy for palliative treatment of gynecological cancers and mostly vulvar squamous cell carcinoma. Some tumors, however, fail to respond to electrochemotherapy. The biological features/determinants for the nonresponsiveness are not determined yet. Patient and methods. A recurrence of vulvar squamous cell carcinoma was treated by electrochemotherapy using intravenous administration of bleomycin. The treatment was performed by hexagonal electrodes according to standard operating procedures. We analyzed the factors that could determine nonresponsiveness to electrochemotherapy. Results. Based on the presented case of nonresponsive vulvar recurrence to electrochemotherapy, we hypothesize that the vasculature of the tumors prior to treatment may predict the response to electrochemotherapy. The histological analysis showed minimal presence of blood vessels in the tumor. Thus, low perfusion may reduce drug delivery and lead to a lower response rate because of the minor antitumor effectiveness of vascular disruption. In this case, no immune response in the tumor was elicited by electrochemotherapy. Conclusions. In this case, of nonresponsive vulvar recurrence treated by electrochemotherapy, we analyzed possible factors that could predict treatment failure. Based on histological analysis, low vascularization of the tumor was observed, which hampered drug delivery and distribution and resulted in no vascular disrupting action of electrochemotherapy. All these factors could contribute to ineffective treatment with electrochemotherapy.
Ključne besede: electrochemotherapy, bleomycin, vulvar cancer
Objavljeno v DiRROS: 25.07.2024; Ogledov: 17; Prenosov: 6
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3. Obravnava bolnic s sumom na raka telesa materniceGregor Vivod, 2023, objavljeni znanstveni prispevek na konferenci Povzetek: Z naraščajočo incidenco raka materničnega telesa v razvitem svetu je v prihodnjih letih
ocenjeno, da bo v Sloveniji za rakom materničnega telesa zbolelo več kot 400 bolnic letno. Z
obravnavo bolnic s sumom ali že znanim rakom telesa maternice se sreča vsak ginekolog.
Začetna obravnava bolnic vključuje anamnezo (družinska, osebna, ginekološka, sedanja),
splošni klinični pregled ter ginekološki klinični pregled z vaginalnim ultrazvokom. V nadaljnji
obravnavi sledi potrditev diagnoze (histeroskopija, abrazija ali aspiracijska biopsija) ter glede
na klinično presojo ustrezna slikovna diagnostika (CT, MR, PET-CT). Stremeti moramo k
optimalni in čimprejšnji diagnostični obravnavi na primarni in sekundarni ravni ter na
učinkovitem zdravljenju (operativni poseg, obsevanje, sistemsko zdravljenje) na terciarni ravni.
Po končanem zdravljenju morajo biti vse bolnice ustrezno sledene.
Ključne besede: rak maternice, ginekološki raki, ginekološka onkologija
Objavljeno v DiRROS: 30.05.2023; Ogledov: 368; Prenosov: 152
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4. Rak telesa maternice : 7. Šola o ginekološkem raku2023, ni določena Povzetek: Pred vami je zbornik, kjer so zbrani prispevki predavanj s področij, ki obravnavajo etiologijo in epidemiologijo raka materničnega telesa, predstavljene so najnovejše smernice obravnave bolnic z rakom materničnega telesa, novosti na področju patološke in molekularne diagnostike, na področju slikovne diagnostike ter dileme na področju operativnega zdravljenja. V zadnjem delu zbornika je predstavljeno sistemsko zdravljenje raka materničnega telesa ter zdravljenje z obsevanjem.
Objavljeno v DiRROS: 24.05.2023; Ogledov: 492; Prenosov: 175
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