291. Poročilo o preskusu št.: LVG 2022-152 : vzorec št. 2022/00568Nikica Ogris, Zina Devetak, Maša Zagorac, Barbara Piškur, 2022, izvedensko mnenje, arbitražna odločba Ključne besede: varstvo gozdov, morfološke analize, bor, Fusarium circinatum, borov smolasti rak
Objavljeno v DiRROS: 30.09.2022; Ogledov: 340; Prenosov: 0 |
292. Poročilo o preskusu št.: LVG 2022-151 : vzorec št. 2022/00566Nikica Ogris, Zina Devetak, Maša Zagorac, Barbara Piškur, 2022, izvedensko mnenje, arbitražna odločba Ključne besede: varstvo gozdov, morfološke analize, bor, Fusarium circinatum, borov smolasti rak
Objavljeno v DiRROS: 30.09.2022; Ogledov: 355; Prenosov: 0 |
293. Poročilo o preskusu št.: LVG 2022-148 : vzorec št. 2022/00561Nikica Ogris, Zina Devetak, Maša Zagorac, Barbara Piškur, 2022, izvedensko mnenje, arbitražna odločba Ključne besede: varstvo gozdov, morfološke analize, Fusarium circinatum, borov smolasti rak, Pinus, bor
Objavljeno v DiRROS: 28.09.2022; Ogledov: 341; Prenosov: 0 |
294. Poročilo o preskusu št.: LVG 2022-131 : vzorec št. 2022/00529Barbara Piškur, Zina Devetak, Maša Zagorac, Andreja Kavčič, 2022, izvedensko mnenje, arbitražna odločba Ključne besede: varstvo gozdov, morfološke analize, Geosmithia morbida, bolezen tisočerih rakov, oreh, Juglans, Pityophthorus juglans
Objavljeno v DiRROS: 28.09.2022; Ogledov: 387; Prenosov: 0 |
295. Poročilo o preskusu št.: LVG 2022-130 : vzorec št. 2022/00554Barbara Piškur, Zina Devetak, Maša Zagorac, 2022, izvedensko mnenje, arbitražna odločba Ključne besede: varstvo gozdov, morfološke analize, Fusarium circinatum, borov smolasti rak, Pinus, bor
Objavljeno v DiRROS: 28.09.2022; Ogledov: 372; Prenosov: 0 |
296. Treatment outcomes and relative dose intensity of chemotherapy in patients with advanced Hodgkin lymphomaSamo Rožman, Barbara Jezeršek Novaković, Nina Ružić Gorenjec, Srdjan Novaković, 2022, izvirni znanstveni članek Povzetek: The present retrospective study was undertaken to investigate the association of relative dose intensity (RDI) with the outcome of patients with advanced stage Hodgkin lymphoma (HL) receiving ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) and escalated BEACOPP regimens (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone). A total of 114 patients with HL treated between 2004 and 2013 were enrolled for evaluation. The association of variables with overall survival (OS) and progression-free survival (PFS) was analysed using univariate and multivariate Cox proportional hazards models. The median age of patients was 39 years, and the majority were male and had stage IV disease. A total of 54 patients received ABVD and 60 received BEACOPP chemotherapy with 24 and four deaths, respectively. Patients in the BEACOPP group were significantly younger with lower Charlson comorbidity index (CCI) and better performance status in comparison with the ABVD group, making the comparison of groups not possible. In the ABVD group, RDI was not significantly associated with OS (P=0.590) or PFS (P=0.354) in a multivariate model where age was controlled. The low number of events prevented this analysis in the BEACOPP group. The age of patients was strongly associated with both OS and PFS; all statistically significant predictors for OS and PFS from univariate analyses (chemotherapy regimen, CCI, RDI, performance status) lost their effect in multivariate analyses where age was controlled. Based on these observations, it was concluded that RDI was not associated with OS or PFS after age is controlled, neither in all patients combined nor in the ABVD group.
Ključne besede: Hodgkin lymphoma, chemotherapy, outcome, primary treatment
Objavljeno v DiRROS: 23.09.2022; Ogledov: 538; Prenosov: 165
 Celotno besedilo (794,55 KB) |
297. Medullary thyroid carcinoma and associated endocrinopathies in Slovenia from 1995 to 2021Sara Milićević, Mateja Krajc, Ana Blatnik, Barbara Perić, 2022, izvirni znanstveni članek Povzetek: Background: Medullary thyroid cancer (MTC) is a rare endocrine tumour that is sporadic in 75% of cases and occurs as a part of inherited cancer syndromes in approximately 25% of cases. The aim of this study was to determine the frequency and type of RET pathogenic variants (PVs) in the Slovenian MTC patient population diagnosed between 1995 and 2021 and to elucidate the full range of associated endocrinopathies. Methods: A retrospective analysis of medical records of 266 MTC patients and their relatives seen in a tertiary centre between 1995 and 2021 was performed. Sequence analysis of exons 10, 11, 13, 14, 15, and 16 of the RET gene was analysed in most patients using Sanger sequencing. From 2017, the entire sequence of RET gene was analysed in most patients using targeted next-generation sequencing. Results: Germline PVs in the RET proto-oncogene were identified in 21.6% probands from 21 different MTC families. Of their tested relatives, 65% (67/103) were RET-positive and 35% (36/103) were RET-negative. PVs were detected in codon 618 and codon 634 in 28.6%, and in codon 790 in 23.8%. The RET-positive group consisted of 52 MTC patients, 13 patients with C cell hyperplasia and 2 individuals with neither. Associated endocrinopathies were diagnosed in 8/21 families: primary hyperparathyroidism (PHPT) in six families and pheochromocytoma (PHEO) in five families. In 62% of RET-positive families (13/21), no associated endocrinopathies were diagnosed. PHEO was most commonly associated with C634R (6/13) and PHPT with C634R (4/7). Hirschsprung’s disease appeared in one patient with RET PV in codon 618. Based on data from the Cancer Registry of Republic of Slovenia, only individual cases of common cancers with well understood environmental risk factors were discovered; lung cancer in 2/21 of families, papillary thyroid cancer in 3/21 of families, cutaneous melanoma in 2/21 of families, cervical cancer in 1/21 families, and lymphoma in 1/21 families. Conclusions: Analysis of prospectively collected MTC cases during a 27-year period revealed that 21.6% of Slovenian patients are RET PV carriers. Sixty-two percent of families had none of the associated endocrinopathies, confirming the thesis that FMTC is the most common presentation. This could suggest using risk-stratified management approaches when screening for PHEO and PHPT in RET PV carriers. However, more studies are needed to evaluate potential genetic risk modifiers as well as safety, improved quality of life, and medical cost reduction in the case of a patient-oriented approach.
Ključne besede: medullary thyroid carcinoma, multiple endocrine neoplasia, primary hyperparathyroidism
Objavljeno v DiRROS: 23.09.2022; Ogledov: 539; Prenosov: 252
Celotno besedilo (248,03 KB)
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298. Poročilo o preskusu št.: LVG 2022-129 : vzorec št. 2022/00254Barbara Piškur, Maarten De Groot, Zina Devetak, Maša Zagorac, Nikica Ogris, 2022, izvedensko mnenje, arbitražna odločba Ključne besede: varstvo gozdov, morfološke analize, borov smolasti rak, Fusarium circinatum, Gibberella circinata, Pinus sp.
Objavljeno v DiRROS: 23.09.2022; Ogledov: 461; Prenosov: 0 |
299. Poročilo o preskusu št.: LVG 2022-128 : vzorec št. 2022/00197Barbara Piškur, Andreja Kavčič, Zina Devetak, Špela Jagodic, Maša Zagorac, Nikica Ogris, 2022, izvedensko mnenje, arbitražna odločba Ključne besede: varstvo gozdov, morfološke analize, borov smolasti rak, Fusarium circinatum, Gibberella circinata, Pinus sp.
Objavljeno v DiRROS: 23.09.2022; Ogledov: 456; Prenosov: 0 |
300. Poročilo o preskusu št.: LVG 2022-127 : vzorec št. 2022/00490Nikica Ogris, Zina Devetak, Maša Zagorac, Barbara Piškur, 2022, izvedensko mnenje, arbitražna odločba Ključne besede: varstvo gozdov, morfološke analize, Geosmithia morbida, bolezen tisočerih rakov, navadni oreh, Juglans regia
Objavljeno v DiRROS: 23.09.2022; Ogledov: 453; Prenosov: 0 |
