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Povzetek: High grade gliomas are associated with cognitive problems. The aim of the study was to investigate cognitive functioning in a cohort of patients with high grade glioma, according to isocitrate dehydrogenase (IDH) and methyl guanine methyl transferase (MGMT) status and other clinical characteristics. The patients with the high-grade glioma treated in Slovenia in given period of time were included in study. Postoperatively they completed neuropsychological assessment consisting of Slovenian Verbal Learning Test, Slovenian Controlled Oral Word Association Test, Trail Making Test Part A and B and self-evaluation questionnaire. We analysed results (z-scores and dichotomized results) also according to IDH mutation and MGMT methylation. We examined differences between groups using T-test, Mann-Whitney U, χ2 and Kendall's Tau tests. Out of 275 patients in the cohort, we included 90. Forty-six percent of patients were unable to participate due to poor performance status and other conditions related to tumour. Patients with the IDH mutation were younger, with better performance status, larger proportions of grade III tumours and MGMT methylation. In this group cognitive functioning is significantly better in the domains of immediate recall, short delayed recall and delayed recall, and in the fields of executive functioning and recognition. There were no differences in cognitive functioning in regard to MGMT status. Grade III tumours were associated with more frequent MGMT methylation. Self-assessment proved week tool, associated only with immediate recall. We found no differences in cognitive functioning according to MGMT status, but cognition was better when IDH mutation was present. In a cohort study of patients with high-grade glioma, almost half were unable to participate in a study, which points to an overrepresentation of patients with better cognitive functioning in the research.
Ključne besede: cognition, high grade glioma, IDH1 mutation
Objavljeno v DiRROS: 25.07.2024; Ogledov: 17; Prenosov: 5
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Povzetek: Background. Since 1974 the term burnout is used in psychology. Burnout describes the end result of stress and has been described by Maslach comprising three basic components: emotional exhaustion, depersonalization andlow personal accomplishment. In this paper we would like to describe some aspects of burnout experiences of the employees of the Institute of Oncology in Ljubljana. Subjects and methods. We used Questionnaire of professional stress, created by Zunter Nagy and Kocmur. In our research 137 health workers from four professional groups participated: physicians, graduated nurses, nurses and radiation engineers, representing 38% of all employees. Results. Wefound out that in the experience the professional stressof all four professional groups is relatively equalized. The most prominent feelings are of fatigue, irritability and work overload. There were no signs of depersonalization - as described by Maslach - reported in our group. In nursesand in radiation engineers a distress is significantly more often displayed due to poorer personal income and poorer material status. Nurses reported significantly more often the intention to change work position (51%),institution (57%) or job (47%). Conclusions. Workstress impacts on the experience and on the thought patterns in those participating in the study. Wecan describe those signs as burnout signs. However, there are more new questions opening in the future as well as the need to a longitudinal approachto the research of this more and more prominent field.
Objavljeno v DiRROS: 06.02.2024; Ogledov: 304; Prenosov: 65
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Ključne besede: duševne stiske, onkologija, bolniki
Objavljeno v DiRROS: 24.05.2023; Ogledov: 528; Prenosov: 145
Celotno besedilo (103,84 KB)

Povzetek: Možganski tumorji so povezani z različnimi težavami v kognitivnem funkcioniranju, ki so odvisni od dejavnikov bolezni, zdravljenja, pa tudi od osebnih dejavnikov bolnika. Kognitivno funkcioniranje ni le manifestacija bolezni, pač pa je tudi en od prognostičnih dejavnikov. Zato je ocenjevanje le-tega pomembno ne le v raziskavah, pač pa tudi pri celostni obravnavi bolnikov z možganskimi tumorji.
Ključne besede: možganski tumorji, centralno živčevje, psihologija
Objavljeno v DiRROS: 16.12.2022; Ogledov: 538; Prenosov: 140
Celotno besedilo (131,55 KB)

Ključne besede: rak dojke, bolniki, zdravljenje, klinične poti
Objavljeno v DiRROS: 14.03.2022; Ogledov: 917; Prenosov: 449
Celotno besedilo (2,09 MB)
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