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Ključne besede: obvladovanje raka, covid-19, javno zdravje
Objavljeno v DiRROS: 07.04.2021; Ogledov: 1363; Prenosov: 357
Celotno besedilo (148,08 KB)

Ključne besede: občanska znanost, ravnanje s podatki, pandemija COVID-19, COVID-19 Sledilnik
Objavljeno v DiRROS: 07.04.2021; Ogledov: 2886; Prenosov: 742
Celotno besedilo (1,02 MB)

Povzetek: Reports of sooty bark disease of maples caused by the fungus Cryptostroma corticale have recently been emerging from across Europe. The aims of our study were to describe the first report of sooty bark disease in Slovenia, to determine the pathogenicity of C. corticale, to confirm the optimum temperature for the growth of the fungus, and to determine the mass loss of Acer pseudoplatanus wood inoculated by C. corticale. We confirmed the presence of C. corticale on A. pseudoplatanus via morphological and molecular analysis. The optimal growth of C. corticale was measured in vitro on potato dextrose agar and was determined to occur at 25 °C. Pathogenicity tests were performed on 30 saplings of A. pseudoplatanus under two treatments, humid and drought stress, and the fungus was pathogenic in both treatments. The mean length of bark lesions and wood discoloration of the drought-stressed saplings was significantly greater than that in the humid treatment. Re-isolations of C. corticale were successful from all inoculated saplings, and thus Koch%s postulates were confirmed. The mass loss of A. pseudoplatanus wood was determined by mini-block test in a period of 10 weeks and was observed as minimal. Based on the results, we conclude that C. corticale is a weak and opportunistic pathogen that most likely expresses itself intensively under hot and dry conditions.
Ključne besede: pathogenicity, drought stress, optimal growth, climate change, mass loss, mini-block test, wood rot, opportunistic pathogen, saprophyte, endophyte
Objavljeno v DiRROS: 23.03.2021; Ogledov: 1163; Prenosov: 876
Celotno besedilo (3,21 MB)
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Povzetek: Background: The role of chemokines in anaphylaxis is unclear. Methods: We prospectively recruited 49 patients presenting to the emergency department with an acute episode of anaphylaxis and 28 healthy subjects. We measured serum levels of the chemokines CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL21, CCL22, CCL24, and CCL26, tryptase, the absolute number of circulating basophils, monocytes, lymphocytes, and PMNs, and whole blood FCER1A, CPA3 and HDC gene expression at two time points: during the anaphylactic episode and in convalescent samples collected approximately 3 months later. We then investigated the in vitro chemotactic activity of chemokines induced during anaphylaxis for the in vitro migration of the corresponding cells. Results: Only CCL2 chemokine levels were signifcantly increased in anaphylaxis samples (median 514 pg/ml) compared to convalescent samples (284 pg/ml, P<0.0001) and healthy subjects (279 pg/ml, P<0.0001); there was no signifcant diference in any of the other chemokines. There was a signifcant positive correlation between the rates of increase of serum CCL2 (median [range]: 106.0% [-44.7% to 557.4%]) and tryptase (133.8% [-6.6% to 893.4%]; r=0.68, P<0.0001) and between the acute concentration of serum CCL2 and the acute concentration of serum tryptase (r=0.77, P<0.0001). The number of circulating basophils, but not other blood cells, signifcantly decreased during anaphylaxis (median 5.0 vs. 19.1 cells/[micro]l in convalescent samples; P<0.0001); a decrease in whole-blood gene expression of basophil markers (PKljučne besede: anaphylaxis, chemokines, tryptases, basophils, chemotaxis, CCL2, cell migration
Objavljeno v DiRROS: 18.01.2021; Ogledov: 1364; Prenosov: 633
Celotno besedilo (2,04 MB)

Povzetek: Venska trombembolija (VTE) je pogost zaplet pri bolnikih z rakom. Zdravljenje VTE pri teh bolnikih predstavlja velik izziv, saj je pri bolnikih z rakom dodatno povečano tako tveganje za trombembolične zaplete kot tudi tveganje za krvavitve. Predstavili bomo nekaj kliničnih situacij, s katerimi se v klinični praksi pogosto srečamo in predstavljajo dileme pri antikoagulacijskem zdravljenju bolnikov z VTE ter rakom, in sicer ponovitve VTE kljub zdravljenju, pojav trombocitopenije, tumorje osrednjega živčevja, uporabo filtrov v spodnji votli veni, uporabo novih peroralnih antikoagulacijskih zdravil in pojav naključno odkrite VTE.
Ključne besede: venska trombembolija, rak (medicina), zdravljenje
Objavljeno v DiRROS: 03.12.2020; Ogledov: 1350; Prenosov: 568
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