1. Lipid-phase-modulated interactions of gold nanoparticles with supported vesicular and planar membranesLaure Bar, Marta Lavrič, Maja Caf, Slavko Kralj, Raj Kumar Sadhu, Miha Škarabot, Aleš Iglič, George Cordoyiannis, Patricia Losada-Pérez, 2026, izvirni znanstveni članek Povzetek: The thorough understanding of the interactions between nanoparticles and lipid membranes has attracted major interest over the past few decades. This spans fundamental biophysics and biomechanics, as well as medical applications, where nanoparticles could serve as potential drug carriers. The influence of the lipid phase in these interactions has been studied to markedly less extent with respect to the nanoparticle size, shape and coating, as well as the presence of electric charge in either the nanoparticles or the membranes. Seeking to gain new insights into the lipid phase, we have systematically investigated the role of the liquid-disordered, the gel-ordered, as well as the seldom-studied ripple phases in modulating the interaction strength between nanoparticles and biomimetic membranes. Supported lipid vesicles and supported lipid bilayers of different composition and amount of electric charge, as well as spherical functionalized Au nanoparticles with and without charge have formed our experimental platform. The results, obtained by quartz crystal microbalance with dissipation monitoring and complemented by atomic force microscopy, reveal a strikingly different mechanistic picture of the interactions between the various lipid phases and types of nanoparticles. We demonstrate enhanced vesicle rupture in the case of stiffer membranes, consistent with recent theoretical studies, yet supported by limited existing experimental evidence. This work advances fundamental understanding of lipid-state-driven nanoparticle–membrane interactions. Such insight is essential, as dynamic changes in bilayer rigidity, composition, and surface charge determine how membranes and nanoparticles interact.
Ključne besede: supported lipid vesicles, supported lipid bilayers, gold nanoparticles, lipid phase, quartz crystal microbalance with dissipation monitoring (QCM-D), nanoparticle-membrane interactions
Objavljeno v DiRROS: 10.04.2026; Ogledov: 8; Prenosov: 9
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2. Titanium nanostructures for biomedical applicationsMukta Vishwanath Kulkarni, Anca Mazare, Ekaterina Gongadze, Šárka Perutková, Veronika Kralj-Iglič, Ingrid Milošev, Patrik Schmuki, Aleš Iglič, Miran Mozetič, 2015, pregledni znanstveni članek Objavljeno v DiRROS: 20.05.2025; Ogledov: 579; Prenosov: 233
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3. Assessment of extracellular particles directly in diluted plasma and blood by interferometric light microscopy : a study of 613 human and 163 canine samplesBoštjan Korenjak, Armando Tratenšek, Matevž Arko, Anna Romolo, Matej Hočevar, Matic Kisovec, Maxence Berry, Apolonija Bedina Zavec, David Drobne, Tomaž Vovk, Aleš Iglič, Alenka Nemec Svete, Vladimira Erjavec, Veronika Kralj-Iglič, 2024, izvirni znanstveni članek Ključne besede: extracellular particles, extracellular vesicles, exosomes, membrane vesiculation, platelets, blood products, platelet-rich plasma, liquid biopsy, membrane enclosed, drug delivery
Objavljeno v DiRROS: 20.12.2024; Ogledov: 1026; Prenosov: 640
Celotno besedilo (1,96 MB)
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4. Short term effect of plant hybridosomes on growth of phaeodactylum tricornutum cultureAnna Romolo, Matej Hočevar, Aleš Iglič, Tjaša Griessler Bulc, Veronika Kralj-Iglič, 2023, objavljeni znanstveni prispevek na konferenci Ključne besede: Phaeodactylum tricornutum, hybridosomes, liposomes, nanoalgosomes, extracellular vesicles, small cellular particles, microalgae
Objavljeno v DiRROS: 21.03.2024; Ogledov: 1219; Prenosov: 763
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8. Scanning electron microscope images of isolates of small cellular particles Phaeodactylum tricornutum grown in media supplemented with Guillard’s (F/2) marine : marine water enrichment solution, BG11 broth and Lennox LB brothApolonija Bedina Zavec, Darja Božič, Matej Hočevar, Aleš Iglič, Marko Jeran, Veronika Kralj-Iglič, Anna Romolo, 2024, objavljeni znanstveni prispevek na konferenci Objavljeno v DiRROS: 08.03.2024; Ogledov: 1584; Prenosov: 753
Celotno besedilo (13,06 MB)
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