1. Integrating genetic insights, technological advancements, screening, and personalized pharmacological interventions in childhood obesityRobert Šket, Barbara Slapnik, Primož Kotnik, Klementina Črepinšek, Barbara Čugalj Kern, Tine Tesovnik, Barbara Jenko Bizjan, Blaž Vrhovšek, Žiga Iztok Remec, Maruša Debeljak, Tadej Battelino, Jernej Kovač, 2025, pregledni znanstveni članek Povzetek: Childhood obesity is a significant global health challenge with rising prevalence over the past 50 years, affecting both immediate and long-term health outcomes. The increase in prevalence from 0.7% to 5.6% in girls and 0.9% to 7.8% in boys highlights the urgency of addressing this epidemic. By 2025, it is estimated that 206 million children and adolescents aged 5–19 years will be living with obesity. This review explores the complex interplay of genomics and genetics in pediatric obesity, transitioning from monogenic and polygenic obesity to epigenetics, and incorporating advancements in omics technologies. The evolutionary purpose of adiposity, systemic evaluation of hyperphagia, and the role of various genetic factors are discussed. Technological advancements in genotyping offer new insights and interventions. The integration of genetic screening into clinical practice for early identification and personalized treatment strategies is emphasized.
Ključne besede: hemophilia, wearable, Florio HAEMO, adherence, patient satisfaction
Objavljeno v DiRROS: 27.11.2025; Ogledov: 105; Prenosov: 59
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2. The usefulness of wearable sensors for detecting freezing of gait in Parkinson’s disease : a systematic reviewMatic Gregorčič, Dejan Georgiev, 2025, pregledni znanstveni članek Povzetek: Background: Freezing of gait (FoG) is one of the most debilitating motor symptoms in Parkinson’s disease (PD). It often leads to falls and reduces quality of life due to the risk of injury and loss of independence. Several types of wearable sensors have emerged as promising tools for the detection of FoG in clinical and real-life settings. Objective: The main objective of this systematic review was to critically evaluate the current usability of wearable sensor technologies for FoG detection in PD patients. The focus of the study is on sensor types, sensor combinations, placement on the body and the applications of such detection systems in a naturalistic environment. Methods: PubMed, IEEE Explore and ACM digital library were searched using a search string of Boolean operators that yielded 328 results, which were screened by title and abstract. After the screening process, 43 articles were included in the review. In addition to the year of publication, authorship and demographic data, sensor types and combinations, sensor locations, ON/OFF medication states of patients, gait tasks, performance metrics and algorithms used to process the data were extracted and analyzed. Results: The number of patients in the reviewed studies ranged from a single PD patient to 205 PD patients, and just over 65% of studies have solely focused on FoG + PD patients. The accelerometer was identified as the most frequently utilized wearable sensor, appearing in more than 90% of studies, often in combination with gyroscopes (25.5%) or gyroscopes and magnetometers (20.9%). The best overall sensor configuration reported was the accelerometer and gyroscope setup, achieving nearly 100% sensitivity and specificity for FoG detection. The most common sensor placement sites on the body were the waist, ankles, shanks and feet, but the current literature lacks the overall standardization of optimum sensor locations. Real-life context for FoG detection was the focus of only nine studies that reported promising results but much less consistent performance due to increased signal noise and unexpected patient activity. Conclusions: Current accelerometer-based FoG detection systems along with adaptive machine learning algorithms can reliably and consistently detect FoG in PD patients in controlled laboratory environments. The transition of detection systems towards a natural environment, however, remains a challenge to be explored. The development of standardized sensor placement guidelines along with robust and adaptive FoG detection systems that can maintain accuracy in a real-life environment would significantly improve the usefulness of these systems.
Ključne besede: Parkinson’s disease, wearable sensors, freezing of gait, symptoms
Objavljeno v DiRROS: 24.11.2025; Ogledov: 100; Prenosov: 54
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3. 2D materials : advances in regenerative medicine and human health sensingJasmina Lazarević, Bojana Višić, 2025, pregledni znanstveni članek Povzetek: The potential of 2D materials goes beyond the use in electronic applications, extending to regenerative medicine and noninvasive sensing. They hold great promise in these fields due to their remarkable properties, such as high surface area, electrical conductivity and modular chemistry. However, they face significant challenges related to biocompatibility, long-term safety, reproducible large-scale production and lack of standardization and clinical protocols, among others. This review presents a comprehensive overview of their application in regenerative medicine and interactions with various biological systems. We comment on the influence of their innate, but tunable properties on biological response. The chemical composition and exfoliation state of these materials also play a critical role in their bioactivity. The high sensitivity of 2D materials to humidity holds a significant promise in sensor development, which is presented here in detail. Combining them with polymer matrices can enhance the flexibility and performance of the sensors, making them suitable for wearable devices and environmental monitoring. However, challenges remain in the search for the best sensing characteristics, which can be addressed through functionalization and combining with alternative materials like metal oxide nanowires. We critically examined the key challenges (biological interactions, exposure risks, environmental changes and scalability), while assessing their potential for sustainable technologies. Despite the advancements, thorough safety assessments are needed before large-scale production and clinical deployment of 2D materials for health sensing applications.
Ključne besede: two-dimensional materials, noninvasive sensing, regenerative medicine, sensor development, wearable sensors
Objavljeno v DiRROS: 19.08.2025; Ogledov: 319; Prenosov: 171
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4. Let's (tik) talk about fitness trendsValdemar Štajer, Ivana Milovanović, Nikola Todorović, Marijana Ranisavljev, Saša Pišot, Patrik Drid, 2022, pregledni znanstveni članek Povzetek: Several factors that follow the development of society affect physical inactivity, which primarily includes the development of technology and digitalization and the increasing choice of unhealthy lifestyle habits. However, certain shifts in the fitness industry have been noted in the last decade. The development of wearable technologies and artificial intelligence is one of the leading fitness trends and undoubtedly represents the future of the fitness industry. On the other hand, the significant influence of social media and networks affects the development and attitudes of people related to physical activity. Therefore, this review paper evaluates the advantages and disadvantages of wearable technologies and artificial intelligence, the positive and negative effects of social networks, and points out the problems accompanying these new fitness trends. The development of fitness trends follows humanity’s needs, and one of the biggest challenges is incorporating these novelties in a mission to improve physical activity levels worldwide.
Ključne besede: modern technologies, social media, social networking platform, physical activity, wearable technologies
Objavljeno v DiRROS: 13.07.2022; Ogledov: 1511; Prenosov: 1135
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