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The new occurrence of antiphospholipid syndrome in severe COVID-19 cases with pneumonia and vascular thrombosis could explain the post-COVID syndrome
Mirjana Zlatković Švenda, Melanija Rašić, Milica Ovuka, Slavica Pavlov Dolijanović, Marija Atanasković Popović, Manca Ogrič, Polona Žigon, Snežna Sodin-Šemrl, Marija Zdravković, Goran Radunović, 2025, izvirni znanstveni članek

Povzetek: Introduction: The classification of antiphospholipid syndrome (APS) comprises clinical criteria (vascular thrombosis or obstetric complications throughout life) and laboratory criteria (antiphospholipid antibodies (aPLs) positivity, confirmed at least twice at 12-week interval). Methods: In 100 patients admitted to the hospital with COVID-19 pneumonia, thrombosis and pregnancy complications were recorded during the hospital stay and in personal medical history. They were tested for nine types of aPLs at four time points (admission, deterioration, discharge, and 3-month follow-up): anticardiolipin (aCL), anti-β2-glycoproteinI (anti-β2GPI), and antiphosphatidylserine/prothrombin (aPS/PT) isotypes IgM/IgG/IgA. Results: During hospitalization, aPLs were detected at least once in 51% of patients. All 7% of deceased patients tested negative for aPLs upon admission, and only one patient became aCL IgG positive as his condition worsened. In 83.3% of patients, intrahospital thrombosis was not related to aPLs. One patient with pulmonary artery and cerebral artery thrombosis was given an APS diagnosis (triple aPLs positivity on admission, double on follow-up). Personal anamnesis (PA) for thromboembolism was verified in 10 patients, all of whom tested negative for aPLs at admission; however, transition to aPLs positivity at discharge (as the disease subsided) was seen in 60% of patients: three of six with arterial thrombosis (at follow-up, two did not appear, and one was negativized) and three of four with deep vein thrombosis (one was confirmed at follow-up and diagnosed with APS, one was negativized, and one did not appear). At admission, the majority of the aPLs were of the aCL IgG class (58.8%). Unexpectedly, as the COVID-19 disease decreased, anti-β2GPI IgG antibodies (linked with thromboses) became newly positive at discharge (14.9%), as confirmed at follow-up (20.8%). Conclusion: The incidence of APS in our cohort was 2.0%, whereas in the general population, it ranges from 0.001% to 0.002%. The incidence might have increased even more if the four aPLs-positive patients with intrahospital thrombosis/history of thrombosis had attended follow-up. Recommendation: All patients with severe COVID-19 or post-COVID syndrome should be evaluated for current/previous thrombosis and tested for aPLs at least twice: at admission to the hospital and at discharge, then retested 3 months later in positive cases in order to be given the appropriate therapy.
Ključne besede: COVID-19, SARS-CoV2, anti-phosphatidylserine-prothrombin (aPS/PT) antibodies, anti-β2-glycoprotein I (anti-β2GPI) antibodies, anticardiolipin (aCL) antibodies, antiphospholipid antibodies (aPLs), antiphospholipid syndrome, immunology, post-COVID syndrome, vascular thrombosis
Objavljeno v DiRROS: 01.12.2025; Ogledov: 78; Prenosov: 37
.pdf Celotno besedilo (1,28 MB)
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A cross-sectional study of laboratory parameters 5–6 months after the first COVID-19 infection
Taja Zore, Jasna Lojk, Katarina Reberšek, Elizabeta Božnar Alič, Urška Čegovnik Primožič, Alenka France Štiglic, Aleš Jerin, Irena Prodan Žitnik, Helena Podgornik, Nada Snoj, Barbara Ostanek, Gabriele Turel, Tatjana Lejko-Zupanc, Janja Marc, Darko Černe, 2025, izvirni znanstveni članek

Povzetek: Objectives: Despite extensive study of COVID-19 disease, only a few studies also addressed the aftermath of the disease and potential long-term consequences. The aim of this study was to assess COVID-19 resolution through the cross-sectional analysis of an extensive range of haematological and biochemical laboratory parameters and to find potential markers still associated with disease severity 5-6-months post infection. Methods: In this study, we analysed 92 routine biochemical, haematological and immunological parameters in 75 non-vaccinated patients 5–6 months after recorded first time SARS-CoV-2 infection without reinfection. Demographic and disease severity data were obtained through surveys. Results: The majority of analysed parameters were within the normal reference intervals, however, statistically significant correlations with the disease severity were detected in 15 parameters: B lymphocytes, NK cells, interleukin (IL)-12, IL-1β, cortisol, ferritin, SARS-CoV-2 specific IgG and IgM antibodies, Na, Cl, creatinine, alkaline phosphatase, cholesterol, HbA1c and alpha 2 and beta 2 globulin fractions of the proteinogram. Conclusions: Although most observed parameters returned to their normal reference intervals, significant correlations were still observed with disease severity, that could indicate either the pre-infection baseline state which affected disease outcome or minor remaining alterations in function of certain organs, pertaining their stress or damage during the acute phase of the disease.
Ključne besede: disease severity, laboratory parameters, resolution, COVID-19, SARS-CoV-2, laboratory diagnosis
Objavljeno v DiRROS: 07.11.2025; Ogledov: 172; Prenosov: 76
.pdf Celotno besedilo (3,36 MB)
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Metavesolje, spletne skupnosti in (resnični) mestni prostor
Asli Ulubaş Hamurc, 2022, pregledni znanstveni članek

Povzetek: With the COVID-19 pandemic, technological advancements and investments accelerated to create an alternative to the real world that makes it possible for various activities and experiences to be handled online. Among these developments, the metaverse comes to the fore because it makes possible real and virtual experiences simultaneously, regardless of the time and space the user exists in, and it acts as a mediator and medium to bring these two environments together. This article discusses the possible impacts of advancements in the metaverse on (real) urban space considering the socio-spatial dialectic through theory synthesis and adaptation. An overall evaluation of the socio-spatial impacts of this is also included and opened up for discussion. Based on a literature review, it is expected that technological developments like the metaverse will introduce a new organization to physical and virtual socio-spatial relations, and new socio-technological groups will be created in them and by using them.
Ključne besede: metaverse, online communities, urban space, COVID-19 pandemic, phygital
Objavljeno v DiRROS: 05.08.2025; Ogledov: 345; Prenosov: 211
.pdf Celotno besedilo (187,36 KB)
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Anxiety and COVID-19 anxiety in positive youth development : a latent profile analysis study
Tina Pivec, Ana Kozina, 2023, izvirni znanstveni članek

Ključne besede: anxiety, covid-19, covid-19 anxiety, positive youth development, PYD, analysis study
Objavljeno v DiRROS: 08.07.2025; Ogledov: 363; Prenosov: 186
.pdf Celotno besedilo (812,61 KB)
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The relative effect of job demands, resources, and personal resources on teaching quality and students' engagement during the COVID-19 pandemic
Žan Lep, Eva Klemenčič Mirazchiyski, Plamen Mirazchiyski, 2023, izvirni znanstveni članek

Povzetek: During the COVID-19 pandemic's school closures and the distance education that resulted from it, teachers were faced with an increasing workload and significant changes in their working environment. Because increased workload can result not only in worsened mental health and lower work motivation, but also in worsened learning outcomes, this article explores how teacher-perceived job demands, job resources, and personal resources are related to teachers' assessment of teaching quality and student engagement during the pandemic. Using the data of 1,422 8th grade teachers in Slovenia from the IEA Responses to Educational Disruptions Survey (REDS) survey, this study also explores the perceived level of support from different institutional actors and the utility of Job demands-resources model for this specific group of workers in a specific work setting. The results show that the teachers of 8th graders in Slovenia perceived a higher level of support from their closest working environment compared to the national bureaucracy. In terms of job demands, the increased workload in preparing the lessons had negative effect on both teaching quality and student engagement, while the reported increase in time spent on direct work with students and social support received (a job resource) contributed positively to both outcome variables. In line with theoretical expectations, personal resources were positive predictors of teaching quality and student engagement in our model. Compared with the initial expectations this study had based on the underlying theoretical model, the results paint a complex relationship between job characteristics and learning outcomes during distance learning. Thus, some of the challenges both teachers and policy-makers face and will continue to face in possible similar situations are discussed.
Ključne besede: job demands, job resources, teachers, teaching quality, student engagement, job demandsrResources model, covid-19
Objavljeno v DiRROS: 08.07.2025; Ogledov: 329; Prenosov: 219
.pdf Celotno besedilo (856,56 KB)
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Anxiety in a COVID-19 school year context : three-way longitudinal study on Slovenian adolescent sample
Ana Kozina, 2023, izvirni znanstveni članek

Povzetek: Background and Objectives:We investigated the trajectories of anxiety,general anxiety and more specifically COVID-19 anxiety in the period ofschool closure in Slovenia using a longitudinal design with three timepoints: at the beginning, in the middle and at the end of the school year.Design and Methods:We have used data from a representativeadolescent sample for Slovenia (n= 1233) and two anxiety scales: theLAOM Anxiety Scale and the COVID-19 Anxiety Scale. Thefindings fromlatent growth curve models show a significant difference in initial levelsand a decrease in both types of anxiety as well as an interaction effectbetween the initial level and the rate of change of COVID-19 anxiety. Inaddition to investigating the change in time, we were interested incovariates.Results and Conclusions:Thefindings show significant effects of: (a)gender, school level and academic achievement on initial levels ofCOVID-19 anxiety; (b) gender and school level on initial levels ofanxiety; (c) gender on the rate of change in anxiety; (d) academicachievement on the rate of change in COVID-19 anxiety; and,additionally, (e) the significant but different role that schoolbelongingness plays in anxiety and in particular COVID-19 anxiety.
Ključne besede: education, schoolbelongingnes, adolescents, grades, gender, covid-19, anxiety, covid-19 anxiety, longitudinal study, Slovenia
Objavljeno v DiRROS: 08.07.2025; Ogledov: 364; Prenosov: 287
.pdf Celotno besedilo (1,27 MB)
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